This paper analyzes the internationalization strategies of biotech firms in the Netherlands. We find that many of these firms are born internationals in the sense that from their inception they are actively engaged in international cooperation. However, we find that the nature of potential intellectual property and technology has a strong influence on the drivers for the internationalization process. In the theory part of the paper we connect IP strategies and technology to separate classes of business models which subsequently translate in dominant internationalization strategies. By presenting case study evidence for the Dutch biotech industry, in the empirical part of the paper we show that technological characteristics explain the variation of internationalization strategies across firms.
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This paper investigates how firms adapt their innovation strategies to cope with constraints in national institutional environments. It is a comparative case study of Dutch and British dedicated biotechnology firms focusing on a particular type of strategy, the hybrid model. Patterns of skill accumulation and learning present in the Dutch hybrids are indications of how they use institutional advantages to focus on low-risk innovation and build deeper competences while also pursuing high-risk innovation strategies. The Dutch hybrid model offers insight into how firms comply with the dominant logic of the biotechnology field even when their institutional frameworks encourage the pursuit of low-risk innovation strategies.
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Why cities need economic intelligenceThe economies of Europe’s cities are changingfast, and it is not easy to predict which segmentsof the local economy will grow and which oneswill decline. Yet, cities must make decisions as towhere to invest, and face a number of questionsthat are difficultto answer:Where dowe putour bets? Should we go for biotech, ICT, or anyother sector that may have growth potential?Do we want to attract large foreign companies,or rather support our local indigenous smallerfirms, ormustwe promotethestart-up scene?Or is it better not to go for any particularindustry but just improve the quality of lifein the city, hoping that this will help to retainskilled people and attract high tech firms?
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Boven titel staat vermeld: De symbiose van biologie en technologie. Zowel vanuit het Applied Science onderwijs als vanuit het werkveld kwam er meer vraag om biologische expertise toe te voegen aan het bestaande lectoraat Thin Films & Functional Materials.
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This paper describes a study into consumers' reasons for buying socially responsible (SR) products, such as Fair Trade products and organic meat. As opposed to other studies, we use a qualitative approach based on 25 in-depth interviews and include several different products in the research. This leads to several new results, such as: (1) buying SR products is perceived as an imperfect moral duty; (2) low quality of SR products is a dissatisfier, but high quality not a satisfier; (3) the attitude towards SR products is related to the reputation of charitable funds; (4) the demand for SR products is negatively related to the frequency of purchasing SR products; (5) reflection on SR products raises the demand for SR products; (6) consumers that have witnessed the social problems that SR products aim to alleviate purchase more SR products. Finally, we find that the demand for different SR products is correlated: if a consumer buys one SR product, it is more likely that (s)he purchases other SR products as well.
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Den Haag en Genève zijn beide gastheer van vele Internationale Organisaties (IO’s) en non-gouvernementele organisaties (ngo’s). West-Europese, middelgrote steden kampen met toegenomen concurrentie op het gebied van het gastheerschap van organisaties als gevolg van de globalisering. Het doel van dit artikel is om Den Haag en Genève te vergelijken op het gebied van hun beleid ten aanzien van IO’s en ngo’s. Dit artikel behandelt de volgende onderzoeksvraag: Hoe is het beleid van Den Haag en Genève op het gebied van aantrekken en behouden van IO’s en ngo’s veranderd en op welke wijze kan de concurrentiepositie van beide steden worden verbeterd? De uitkomsten: Genève richt zich meer op het behouden terwijl Den Haag daarnaast ook focust op het aantrekken van organisaties. Genève is een omnivoor terwijl Den Haag zich vooral richt op thema’s als Vrede en Recht. Verbeterpunten zijn: internationale bereikbaarheid en medische voorzieningen (Den Haag), de woningmarkt en het parkeerprobleem (Genève), kinderopvang en het scheppen van discussiecentra (beide).
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From PLoS website: In general, dietary antigens are tolerated by the gut associated immune system. Impairment of this so-called oral tolerance is a serious health risk. We have previously shown that activation of the ligand-dependent transcription factor aryl hydrocarbon receptor (AhR) by the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects both oral tolerance and food allergy. In this study, we determine whether a common plant-derived, dietary AhR-ligand modulates oral tolerance as well. We therefore fed mice with indole-3-carbinole (I3C), an AhR ligand that is abundant in cruciferous plants. We show that several I3C metabolites were detectable in the serum after feeding, including the high-affinity ligand 3,3´-diindolylmethane (DIM). I3C feeding robustly induced the AhR-target gene CYP4501A1 in the intestine; I3C feeding also induced the aldh1 gene, whose product catalyzes the formation of retinoic acid (RA), an inducer of regulatory T cells. We then measured parameters indicating oral tolerance and severity of peanut-induced food allergy. In contrast to the tolerance-breaking effect of TCDD, feeding mice with chow containing 2 g/kg I3C lowered the serum anti-ovalbumin IgG1 response in an experimental oral tolerance protocol. Moreover, I3C feeding attenuated symptoms of peanut allergy. In conclusion, the dietary compound I3C can positively influence a vital immune function of the gut.
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Introduction: Strenuous physical stress induces a range of physiological responses, the extent depending, among others, on the nature and severity of the exercise, a person’s training level and overall physical resilience. This principle can also be used in an experimental set-up by measuring time-dependent changes in biomarkers for physiological processes. In a previous report, we described the effects of workload delivered on a bicycle ergometer on intestinal functionality. As a follow-up, we here describe an analysis of the kinetics of various other biomarkers. Aim: To analyse the time-dependent changes of 34 markers for different metabolic and immunological processes, comparing four different exercise protocols and a rest protocol. Methods: After determining individual maximum workloads, 15 healthy male participants (20–35 years) started with a rest protocol and subsequently performed (in a cross-over design with 1-week wash-out) four exercise protocols of 1-h duration at different intensities: 70% Wmax in a hydrated and a mildly dehydrated state, 50% Wmax and intermittent 85/55% Wmax in blocks of 2 min. Perceived exertion was monitored using the Borg’ Rating of Perceived Exertion scale. Blood samples were collected both before and during exercise, and at various timepoints up to 24 h afterward. Data was analyzed using a multilevel mixed linear model with multiple test correction. Results: Kinetic changes of various biomarkers were exercise-intensity-dependent. Biomarkers included parameters indicative of metabolic activity (e.g., creatinine, bicarbonate), immunological and hematological functionality (e.g., leukocytes, hemoglobin) and intestinal physiology (citrulline, intestinal fatty acid-binding protein, and zonulin). In general, responses to high intensity exercise of 70% Wmax and intermittent exercise i.e., 55/85% Wmax were more pronounced compared to exercise at 50% Wmax. Conclusion: High (70 and 55/85% Wmax) and moderate (50% Wmax) intensity exercise in a bicycle ergometer test produce different time-dependent changes in a broad range of parameters indicative of metabolic activity, immunological and hematological functionality and intestinal physiology. These parameters may be considered biomarkers of homeostatic resilience. Mild dehydration intensifies these time-related changes. Moderate intensity exercise of 50% Wmax shows sufficient physiological and immunological responses and can be employed to test the health condition of less fit individuals.
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This paper analyses co-creation in urban living labs through a multi-level network perspective on system innovation. We draw on the case House of Skills, a large, multi-stakeholder living lab aimed at developing a ‘skills-based’ approach towards labour market innovation within the Amsterdam Metropolitan Region. Ouranalysis helps understand stakeholder dynamics towards system innovation, drawing on an innovative living lab example and taking into consideration the multi-layered structures that comprise the collaboration. Our conceptual framework provides an important theoretical contribution to innovation studies and offers a practical repertoire that can help practitioners improve co-creation of shared value in living labs, towards orchestrating flexible structures that strengthen the impact of their initiatives.
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Uit het vooronderzoekvan het project Duurzamelearning communities: Oogstenin de Greenportblijkt dat12 factorenhierbijvan belangrijk zijn. Deze succesfactoren staan centraal in de interactieve tool Seeds of Innovation. Ook komen uit het vooronderzoek, aangevuld met inzichten uit de literatuur en tips om de samenwerking door te ontwikkelen en meer gebruik te maken van de opbrengsten 12 succesfactoren met toelichting, belangrijkste bevindingen en tips voor ‘hoe nu verder’, Poster, Walk through, De app die learning communities helptde samenwerkingnaareenhogerplan te tillenen innovatieveopbrengstenoptimaalte benutten.
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