The importance of water and energy accessibility and use has become more important as new insight into their role for sustainable development goals has become mainstream. The inclusion of water and energy in strategic decision-making is thus key. Supply chain network design (SCND) in the food industry is an interesting case study for the incorporation of water and energy utilization during the design process of global production systems. In the current green SCND research, frequently, single indicators are used such as carbon emissions to measure environmental impact. This paper presents a case study applied to an orange juice supply chain, formulated as a multi-objective optimization model. A single environmental impact indicator optimization approach is paired against one that includes water and energy use explicitly in the objective function set. Mixed conclusions are shown from the results pairing the two strategies side by side.