Already for many centuries shoemaking exists as a craft. Orthopaedic shoemaking is a relative new profession that has emerged and evolved during the last century. Originated from the craft of shoemaking it has developed into a profession on the intersection between healthcare and technology. Important drivers were unity of language, developments in science and technology, but also developments in the relationship with society. Whereas in the past shoes were made for patients, today shoes are made with patients, driven by patients’ requirements. This development urges orthopaedic shoemaking to shift from shoe design to the design of mobility solutions, to adopt new ways of interdisciplinary cooperation and to innovate the manufacturing process. This offers many opportunities for research.