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Comprehensive analytical and clinical evaluation of a RNA extraction-free saliva-based molecular assay for SARS-CoV-2

Standard SARS-CoV-2 testing protocols using nasopharyngeal/throat (NP/T) swabs are invasive and require trained medical staff for reliable sampling. In addition, it has been shown that PCR is more sensitive as compared to antigen-based tests. Here we describe the analytical and clinical evaluation of our in-house RNA extraction-free saliva-based molecular assay for the detection of SARS-CoV-2. Analytical sensitivity of the test was equal to the sensitivity obtained in other Dutch diagnostic laboratories that process NP/T swabs. In this study, 955 individuals participated and provided NP/T swabs for routine molecular analysis (with RNA extraction) and saliva for comparison. Our RT-qPCR resulted in a sensitivity of 82,86% and a specificity of 98,94% compared to the gold standard. A false-negative ratio of 1,9% was found. The SARS-CoV-2 detection workflow described here enables easy, economical, and reliable saliva processing, useful for repeated testing of individuals.

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On the Dry port to Dry port-concept Gaining a better understanding of the added value

This research is part of a project which has been initiated by the Indonesian province of West Java and the Dutch province of Gelderland. The overall aim of the project is to create a seamless multi-modal supply chain between the two provinces, whereby increasing the sustainability and (cost-)efficiency of logistics activities. It is expected that this can be achieved by means of a Dry port to Dry port-concept (DP2DP-concept). The study presented in this paper focuses on the (potential) added value of a DP2DP-concept. This contribution first provides insight into what a dry port to dry port (DP2DP) concept entails. In addition, it also provides an overview of the key logistics performance indicators in the context of this concept. Finally, the added value of a DP2DP concept is elaborated on for each of the identified performance indicators.

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On the Dry port to Dry port-concept Gaining a better understanding of the added value

This research is part of a project which has been initiated by the Indonesian province of West Java and the Dutch province of Gelderland. The overall aim of the project is to create a seamless multi-modal supply chain between the two provinces, whereby increasing the sustainability and (cost-)efficiency of logistics activities. It is expected that this can be achieved by means of a Dry port to Dry port-concept (DP2DP-concept). The study presented in this paper focuses on the (potential) added value of a DP2DP-concept. This contribution first provides insight into what a dry port to dry port (DP2DP) concept entails. In addition, it also provides an overview of the key logistics performance indicators in the context of this concept. Finally, the added value of a DP2DP concept is elaborated on for each of the identified performance indicators.

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Workshop Effectieve planningstools voor hv/lv 2023-02-15

Deelnemers: 15 Op woensdag 15 februari gaan Pascal Pollet en Jannes Slomp in op de planningsproblematiek waar veel high-variety/low-volume bedrijven mee worstelen en de vaak beperkte effectiviteit van planningtools. In de workshop komt de link tussen product-, productie- en besturingsstructuur aan de orde. Ook wordt ingegaan op verschillende planningssystemen en de achterliggende principes. Deelnemers worden uitgedaagd om de eigen situatie kritisch te analyseren en systematisch te zoeken naar verbeteringen. WAT NEMEN DEELNEMERS MEE? De deelnemer (planner, productiemanager, plantmanager) krijgt inzicht in de problematiek van planning in een high-variety/low-volume omgeving en manieren waarop hij/zij deze problematiek kan verlichten. Op basis hiervan maakt en bespreekt de deelnemer een verbeterplan voor de eigen situatie. WERKVORM Naast de benodigde theorie en bespreking van casussen zal er ruim tijd zijn voor oefeningen en kleine games die de kracht en de werkzaamheid van de verschillende principes duidelijk maken. Ook is er ruimte voor discussie. Pascal Pollet Pascal Pollet heeft een grondige ervaring in lean manufacturing en in de implementatie van zelfsturende systemen. Sinds 2009 helpt hij bedrijven om hun levertijd radicaal te verkorten met de 'quick response manufacturing'-strategie.

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Workshop Effectieve planningstools voor hv/lv 2023-02-15

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Children's route choice during active transportation to school : difference between shortest and actual route

Background: The purpose of this study is to increase our understanding of environmental correlates that are associated with route choice during active transportation to school (ATS) by comparing characteristics of actual walking and cycling routes between home and school with the shortest possible route to school. Methods: Children (n = 184; 86 boys, 98 girls; age range: 8–12 years) from seven schools in suburban municipalities in the Netherlands participated in the study. Actual walking and cycling routes to school were measured with a GPS-device that children wore during an entire school week. Measurements were conducted in the period April–June 2014. Route characteristics for both actual and shortest routes between home and school were determined for a buffer of 25 m from the routes and divided into four categories: Land use (residential, commercial, recreational, traffic areas), Aesthetics (presence of greenery/natural water ways along route), Traffic (safety measures such as traffic lights, zebra crossings, speed bumps) and Type of street (pedestrian, cycling, residential streets, arterial roads). Comparison of characteristics of shortest and actual routes was performed with conditional logistic regression models. Results: Median distance of the actual walking routes was 390.1 m, whereas median distance of actual cycling routes was 673.9 m. Actual walking and cycling routes were not significantly longer than the shortest possible routes. Children mainly traveled through residential areas on their way to school (>80 % of the route). Traffic lights were found to be positively associated with route choice during ATS. Zebra crossings were less often present along the actual routes (walking: OR = 0.17, 95 % CI = 0.05–0.58; cycling: OR = 0.31, 95 % CI = 0.14–0.67), and streets with a high occurrence of accidents were less often used during cycling to school (OR = 0.57, 95 % CI = 0.43–0.76). Moreover, percentage of visible surface water along the actual route was higher compared to the shortest routes (walking: OR = 1.04, 95 % CI = 1.01–1.07; cycling: OR = 1.03, 95 % CI = 1.01–1.05). Discussion: This study showed a novel approach to examine built environmental exposure during active transport to school. Most of the results of the study suggest that children avoid to walk or cycle along busy roads on their way to school. https://doi.org/10.1186/s12966-016-0373-y

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Children's route choice during active transportation to school : difference between shortest and actual route

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EV charging plaza_ A data-driven case study

This paper presents data-driven insights from a case study that was carried out in an University EV charging plaza where EV charging demand is met with the combination of the University campus grid and installed solar capacity. First, we assessed the plaza dependency on the grid for meeting EV charging demand and intake of excess solar energy using the available dataset. By modifying the plaza network to accommodate a small approx. 50 kWh battery storage can significantly reduce the grid dependency of the plaza by approx. 30% compared to the present situation and can also increase the green energy utility for EV charging by 10-20%. Having an battery storage could also help overcome the limitations due to the campus grid capacity during EV charging peak demand by means of scheduling algorithms. Second, we assessed the utility rate of the plaza which indicated that the average utility of charging infrastructure is about 30% which has an increasing trend over the analysed period. The low utility and EV charging peak demand may be the result of current EV user behavior where the average idle time during charging sessions is found to be approx. 90 minutes. Reduction in idle time by one third may increase the capacity and utility of plaza by two to two and half times the forecasted daily demand. By having the campus grid capacity and user information may further help with effect EV demand forecasting and scheduling.

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EV charging plaza_ A data-driven case study

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An analysis and design for the repair process of Late Show shipments in the Export Cargo Process at SPL HUB

Export shipments arriving late at the freight building of KLM Cargo at Schiphol Airport is a trigger to deviations in the standard acceptance process. These Late Shows are currently handled ad-hoc making it difficult to plan and predict these events. In addition, shipments arriving on time is currently not a criterion for acceptance, while a shipment should depart on the flight planned at the moment of acceptance or the quality of the process deteriorates. By conducting a data analysis to quantitatively identify the characteristics of the Late Shows, and by conducting stakeholder interviews to understand the current process and discuss the future process, this research tried to design the operational process of the Late Shows to improve the operational excellence and quality of the acceptance process. The research shows that currently, late shipments are often still tried to be build up for the planned flight. It is found that 13% of these shipments do eventually not depart on the planned flight, while being accepted by KLM Cargo, deteriorating the quality of the process. The research concludes that the design of the Late Show process should include a check on whether the shipment was delivered on time, before acceptance of the shipment. By only accepting the shipment once it is decided that the planned flight is achievable or when it is rebooked to another flight, it is assured that the Late Show will be on time at the buildup buffer for the booked flight.

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An analysis and design for the repair process of Late Show shipments in the Export Cargo Process at SPL HUB

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Prevalence of male DNA on female worn undergarments. How small datasets may support robust opinions in activity level evaluative reporting

In cases of sexual assault, the interpretation of biological traces on clothing, and particularly undergarments, may be complex. This is especially so when the complainant and defendant interact socially, for instance as (ex-)partners or by co-habitation. Here we present the results from a study where latent male DNA on female worn undergarments is recovered in four groups with different levels of male-female social interaction. The results conform to prior expectation, in that less interaction tend to result in less male DNA on undergarments. We explore the use of these experimental data for evaluative reporting given activity level propositions in a mock case scenario. We show how the selection of different populations to represent the social interaction between complainant and defendant may affect the strength of the evidence. We further show how datasets of limited size can be used for robust activity level evaluative reporting.

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Prevalence of male DNA on female worn undergarments. How small datasets may support robust opinions in activity level evaluative reporting

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Performance of Unreliable Merging Lines with Uneven Buffer Capacity Allocation

The purpose of this study is to investigate the impact that unevenly allocating buffer capacity has on throughput and average buffer level regarding unreliable lines to better understand the relevant factors in supply chain design. Results show that the best patterns for unreliable merging lines in terms of generating higher throughput rates (TR), as compared to a balanced merging line counterpart, are those where total available buffer capacity is allocated between workstations in either an inverted bowl pattern (i.e. concentrating buffer capacity towards the centre of the line), or a balanced line pattern. In contrast, when considering the trade-off between generating revenue resulting from TR and reducing cost created by average buffer levels (ABL), we found that the balanced pattern was not the best pattern. The best pattern was dependent on the length of the line and on the total buffer capacity as shorter lines with very constrained buffers were best served with an inverted bowl pattern while longer lines had the best results when applying an ascending buffer allocation pattern. Longer lines, in contrast, had the best results regarding the trade-off between TR and ABL, on average, by allocating buffer capacity evenly in one of the parallel lines while applying any other pattern in the remaining parallel line.

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Comprehensive analytical and clinical evaluation of a RNA extraction-free saliva-based molecular assay for SARS-CoV-2

On the Dry port to Dry port-concept Gaining a better understanding of the added value

On the Dry port to Dry port-concept Gaining a better understanding of the added value

Workshop Effectieve planningstools voor hv/lv 2023-02-15

Children's route choice during active transportation to school : difference between shortest and actual route

EV charging plaza_ A data-driven case study

An analysis and design for the repair process of Late Show shipments in the Export Cargo Process at SPL HUB

Prevalence of male DNA on female worn undergarments. How small datasets may support robust opinions in activity level evaluative reporting

Performance of Unreliable Merging Lines with Uneven Buffer Capacity Allocation

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Products 140

Comprehensive analytical and clinical evaluation of a RNA extraction-free saliva-based molecular assay for SARS-CoV-2

On the Dry port to Dry port-concept Gaining a better understanding of the added value

On the Dry port to Dry port-concept Gaining a better understanding of the added value

Workshop Effectieve planningstools voor hv/lv 2023-02-15

Children's route choice during active transportation to school : difference between shortest and actual route

EV charging plaza_ A data-driven case study

An analysis and design for the repair process of Late Show shipments in the Export Cargo Process at SPL HUB

Prevalence of male DNA on female worn undergarments. How small datasets may support robust opinions in activity level evaluative reporting

Performance of Unreliable Merging Lines with Uneven Buffer Capacity Allocation