DOI:https://doi.org/10.14261/postit/F20ECDBA-3106-4133-9EE0714DBAA65B51In 2015 and 2016, Saxion University of Applied Sciences organized the 2nd and 3rd edition of the Regional Innovation and Entrepreneurship Conference (RIEC). The book that is in front of you now is the result of these two conferences and consists of a number of keynote speeches as well as selected articles that were presented during the different sessions of the conference. The goal of the RIEC is to add some thoughts to the debate about the influence of innovation and entrepreneurship on regional economic development and vice versa.