Designing meaningful audio for interactive applications such as video games or sonic user interfaces, presents designers with several challenges. One challenge is the fact that the perception of musical meaning involves cultural or learned aspects when it comes to tonality (Huron, 2006; Patel, 2008). For applied music and sound design, as cross-cultural phenomenon, this cultural specificity appears to be a significant disadvantage. Nevertheless, the history of interactive music in video games and sonic user interfaces illuminates many successful examples of meaningful musical icons in classic arcade games such as Pac-Man (1980), Donkey Kong (1981), Super Mario World (1990) and Pong (1972) and the user interface sounds of operating systems.