Entrepreneurship and entrepreneurship education is generally viewed upon as being important for economic growth in the 21st century. Teaching entrepreneurship however seems to need another approach to fulfill the changing needs. In this perspective active learning and constructivism is generally seen as essential. Other elements that are influencing the teaching process are attention for competences, culture, the needs of the student and the curriculum. So the design of the curriculum must address these changing demands of society. Effectuation, constructivism and andragogy are the key elements for the curriculum to meet the criteria for delivering sustainable and flexible professionals to society. Based on practical experiences in the last decades in the Region of Twente, elements for an entrepreneurial curriculum are elaborated in this article.