De African Digital Rights Network (ADRN) heeft een nieuw rapport gepubliceerd waarin de toevoer en verspreiding van digitale surveillance technologie in Afrika in kaart is gebracht. Onderzoeker Anand Sheombar van het lectoraat Procesinnovatie & Informatiesystemen is betrokken bij het ADRN-collectief en heeft samen met de Engelse journalist Sebastian Klovig Skelton, door middel van desk research de aanvoerlijnen vanuit Westerse en Noordelijke landen geanalyseerd. De bevindingen zijn te lezen in dit Supply-side report hoofdstuk van het rapport. APA-bronvermelding: Klovig Skelton, S., & Sheombar, A. (2023). Mapping the supply of surveillance technologies to Africa Supply-side report. In T. Roberts (Ed.), Mapping the Supply of Surveillance Technologies to Africa: Case Studies from Nigeria, Ghana, Morocco, Malawi, and Zambia (pp. 136-167). Brighton, UK: Institute of Development Studies.
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PURPOSE: To determine the impact of late radiation-induced toxicity on health-related quality of life (HRQoL) among patients with prostate cancer.PATIENTS AND METHODS: The study sample was composed of 227 patients, treated with external beam radiotherapy. Common Terminology Criteria for Adverse Events version 3.0 were used to grade late genitourinary and gastrointestinal toxicity. The European Organization for Research and Treatment of Cancer Quality of life Questionnaire C30 (EORTC QLQ-C30) was used to assess HRQoL at baseline, and 6, 12 and 24 months after completion of radiotherapy. Statistical analysis was performed using a multivariate analysis of variance (MANOVA).RESULTS: Urinary incontinence and rectal discomfort significantly affected HRQoL. The impact of urinary incontinence on HRQoL was most pronounced 6 months after radiotherapy and gradually decreased over time. The impact of rectal discomfort on HRQoL was predominant at 6 months after radiotherapy, decreased at 12 months and increased again 2 years after radiotherapy. No significant impact on HRQoL was observed for any of the other toxicity endpoints, or non-toxicity related factors such as hormonal therapy, radiotherapy technique or age.CONCLUSION: Urinary incontinence and rectal discomfort have a significant impact on HRQoL. Prevention of these side effects may likely improve quality of life of prostate cancer patients after completion of treatment.
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Cervical dystonia is the most frequent form of focal dystonia. Symptoms often result in pain and functional disability. Local injections of botulinum neurotoxin are currently the treatment of choice for cervical dystonia. Although this treatment has proven effective and is widely applied worldwide, many issues still remain open in the clinical practice. We performed a systematic review of the literature on botulinum toxin treatment for cervical dystonia based on a question-oriented approach, with the aim to provide practical recommendations for the treating clinicians. Key-questions from the clinical practice were explored. Results suggest that while the beneficial effect of botulinum toxin treatment on different aspects of cervical dystonia is well established, robust evidence is still missing concerning some practical aspects, such as doseequivalence between different formulations, optimal treatment intervals, treatment approaches, and the use of supportive techniques including electromyography (EMG) or ultrasounds. Established strategies to prevent or manage common side effects (including excessive muscle weakness, pain at injection site, dysphagia) and potential contraindications to this treatment (pregnancy and lactation, use of anticoagulants, neurological comorbidities) should also be further explored.
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From the website of the publisher: "Botanicals, which are basis of many plant food supplements (PFS), constitute the major part of worldwide and historically founded traditional medicines (TM) used to cure diseases and maintain health. A recently published trilogy called “The Art and Science of Traditional Medicine”, published by Science/AAAS (2015a, b, 2014) reveals many research aspects and examples of TM including the complexity of efficacy and safety testing of botanicals. It also exemplifies currently available innovative options to ensure and improve quality of TM (from Traditional Chinese Medicine, to Ayurveda and classic Greek, Roman and Celts’ medicines). The WHO, who in view of their Traditional Medicine Strategy 2014–2023 triggered this trilogy, aims to promote TM as a worldwide affordable health care option." Co-authors Mario Dell’AgliEmail authorChiara Di LorenzoEnrico SangiovanniGary WilliamsonPaolo MeoniPatrizia Restani
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The study presented in this chapter aims at providing the foundation for future research examining the potential negative results of open ads. In past decades there has been a shift toward ads with less guidance toward a specific interpretation. Different terms have been used to denote these ads-for instance, complex image ads, implicit ads, ambiguous ads, and undercoded ads. Open ads have the common characteristic that consumers are not manifestly directed toward a certain interpretation. We formulate five antecedents that render an ad more open: presence of a prominent visual, presence of rhetorical figures, absence of the product, absence of verbal anchoring, and a low level of brand anchoring. We distinguish four categories of open ads: riddle ads, story ads, issue ads, and aesthetic ads. Although the literature generally stresses positive outcomes of openness on consumer reactions, five experiments show preliminary support for the arguments stressing a possible dark side of openness for consumer response. We have found negative effects of openness on interpretation, attitude toward the ad and the brand, and null-effects on attention and recall.
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Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved in these glucocorticoid-induced side effects, and especially the participation of adipose tissue in this are not completely understood. We used a combination of transcriptomics, antibody arrays and bioinformatics approaches to characterize prednisolone-induced alterations in gene expression and adipokine secretion, which could underlie metabolic dysfunction in 3T3-L1 adipocytes. Several pathways, including cytokine signalling, Akt signalling, and Wnt signalling were found to be regulated at multiple levels, showing that these processes are targeted by prednisolone. These results suggest that mechanisms by which prednisolone induce insulin resistance include dysregulation of wnt signalling and immune response processes. These pathways may provide interesting targets for the development of improved glucocorticoids.
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Abstract Managing adverse drug reactions (ADRs) is a challenge, especially because most healthcare professionals are insufficiently trained for this task. Since context-based clinical pharmacovigilance training has proven effective, we assessed the feasibility and effect of a creating a team of Junior-Adverse Drug Event Managers (J-ADEMs). The J-ADEM team consisted of medical students (1st–6th year) tasked with managing and reporting ADRs in hospitalized patients. Feasibility was evaluated using questionnaires. Student competence in reporting ADRs was evaluated using a case-control design and questionnaires before and after J-ADEM program participation. From Augustus 2018 to Augustus 2019, 41 students participated in a J-ADEM team and screened 136 patients and submitted 65 ADRs reports to the Netherlands Pharmacovigilance Center Lareb. Almost all patients (n = 61) found it important that “their” ADR was reported, and all (n = 62) patients felt they were taken seriously by the J-ADEM team. Although attending physicians agreed that the ADRs should have been reported, they did not do so themselves mainly because of a “lack of knowledge and attitudes” (50%) and “excuses made by healthcare professionals” (49%). J-ADEM team students were significantly more competent than control students in managing ADRs and correctly applying all steps for diagnosing ADRs (control group 38.5% vs. intervention group 83.3%, p < 0.001). The J-ADEM team is a feasible approach for detecting and managing ADRs in hospital. Patients were satisfied with the care provided, physicians were supported in their ADR reporting obligations, and students acquired relevant basic and clinical pharmacovigilance skills and knowledge, making it a win-win-win intervention.
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This paper presents a report of some of the activities of the International Energy Agency's (IEA) Wind TCP Task 39. By identifying best practices in an international collaboration, Task 39 hopes to provide the scientific evidence to inform improved regulations and standards, increasing the effectiveness of quiet wind turbine technology. Task 39 is divided into five separate work packages, which address the broad wind turbine noise topic in successive steps; from wind turbine noise generation (WP2), to airborne noise propagation over large distances (WP3). The assessment of wind turbine noise and its impact on humans is addressed in WP4, while WP5 is dealing with other aspects of perception and acceptance, which may be related to noise. All WPs contribute to a dedicated Work Package on dissemination (WP1). This paper provides an update of activities primarily associated with the socio-psychological aspects of wind turbine noise (WP4 and WP5). Through the consideration of a wide variety of factors, including measurement technologies, auralisation and psychology, the effects on noise perception, annoyance and its impact on wellbeing and health is being further investigated. This paper presents a discussion of the activities of each member country and highlights some of the key research questions that need to be further considered.
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BACKGROUND: Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive drugs. However, prolonged use at a medium or high dose is hampered by side effects of which the metabolic side effects are most evident. Relatively little is known about their effect on gene-expression in vivo, the effect on cell subpopulations and the relation to the efficacy and side effects of GCs.AIM: To identify and compare prednisolone-induced gene signatures in CD4⁺ T lymphocytes and CD14⁺ monocytes derived from healthy volunteers and to link these signatures to underlying biological pathways involved in metabolic adverse effects.MATERIALS & METHODS: Whole-genome expression profiling was performed on CD4⁺ T lymphocytes and CD14⁺ monocytes derived from healthy volunteers treated with prednisolone. Text-mining analyses was used to link genes to pathways involved in metabolic adverse events.RESULTS: Induction of gene-expression was much stronger in CD4⁺ T lymphocytes than in CD14⁺ monocytes with respect to fold changes, but the number of truly cell-specific genes where a strong prednisolone effect in one cell type was accompanied by a total lack of prednisolone effect in the other cell type, was relatively low. Subsequently, a large set of genes was identified with a strong link to metabolic processes, for some of which the association with GCs is novel.CONCLUSION: The identified gene signatures provide new starting points for further study into GC-induced transcriptional regulation in vivo and the mechanisms underlying GC-mediated metabolic side effects.
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Like many countries, the COVID-19 pandemic has forced Statistics Netherlands to make changes in its fieldwork strategy. Since mid-March 2020, there have been limited opportunities to conduct face-to-face interviews. Therefore, from September 2020, CAPI sampled people are offered the opportunity to respond by telephone. For this purpose, face-to-face interviewers are instructed to persuade the potential respondent at the doorway. When people refuse a face-to-face interview, interviewers ask for a telephone number and try to make an appointment to conduct the interview by telephone. The aim of our study was to investigate the effects of conducting the interview by telephone instead of face-to-face on important survey outcome variables. We were particularly interested in whether differences are due to selection effects or caused by mode-specific measurement errors. Because we did not have the time or capacity to set up a controlled experiment, we performed regression analyses to decompensate the differences between selection effects and mode-specific measurement errors. We used data of the Labour Force Survey (LFS) and the Housing Survey (WoON). Our analysis showed that there were differences in important target variables, for both LFS and WoON. These differences were, however, mainly caused by selection effects – which can be taken into account for during weighting – and were less likely to be caused by mode specific measurement errors. Although there are important limitations and caveats, these findings are supportive to further implement this field strategy.
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