The wrist allows the hand to combine dorsopalmar flexion and radioulnar deviation, a unique combination of functions that is made possible by a highly complex system of joints. The morphologic features of the carpal bones and of the radiocarpal and intercarpal contacts can be functionally interpreted by the mechanism that underlies the movements of the hand to the forearm. Displacements of the carpals take place in longitudinal articulation chains, with the proximal carpals having the position of an intercalated bone. The three articulation chains, radial, central, and ulnar, have interdependent movements at the radiocarpal and midcarpal levels. The linkage of movements in the longitudinal direction is associated to a transverse linkage by mutual joint contacts and by specific ligamentous interconnections. Kinematic analyses of the carpal joint motions have provided convincing evidence that each motion of the hand to the forearm demonstrates a specific motion pattern of the carpal bones. The stability of the carpus essentially depends on the integrity of the ligamentous system which consists of interwoven fiber bundles that differ in length, direction, and mechanical properties. Distinct separations into morphologic entities are difficult to make. From a functional point of view, the ligamentous interconnections can be regarded as a system that passively restricts movements of the carpals on one another and on the radius, but in a very differentiated way. The ligamentous system controls the linkage of the movements of the carpals, with the geometries of the bones and of the joint surfaces being, first of all, responsible for the kinematic behavior of the carpal joint.
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Understanding taste is key for optimizing the palatability of seaweeds and other non-animal-based foods rich in protein. The lingual papillae in the mouth hold taste buds with taste receptors for the five gustatory taste qualities. Each taste bud contains three distinct cell types, of which Type II cells carry various G protein-coupled receptors that can detect sweet, bitter, or umami tastants, while type III cells detect sour, and likely salty stimuli. Upon ligand binding, receptor-linked intracellular heterotrimeric G proteins initiate a cascade of downstream events which activate the afferent nerve fibers for taste perception in the brain. The taste of amino acids depends on the hydrophobicity, size, charge, isoelectric point, chirality of the alpha carbon, and the functional groups on their side chains. The principal umami ingredient monosodium l-glutamate, broadly known as MSG, loses umami taste upon acetylation, esterification, or methylation, but is able to form flat configurations that bind well to the umami taste receptor. Ribonucleotides such as guanosine monophosphate and inosine monophosphate strongly enhance umami taste when l-glutamate is present. Ribonucleotides bind to the outer section of the venus flytrap domain of the receptor dimer and stabilize the closed conformation. Concentrations of glutamate, aspartate, arginate, and other compounds in food products may enhance saltiness and overall flavor. Umami ingredients may help to reduce the consumption of salts and fats in the general population and increase food consumption in the elderly.
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Phd Thesis Higher professional education aims to prepare graduates for the complexity of professional practices. The development of conceptual understanding is important to deal adequately with this complexity, especially in an unstructured professional domain such as international business. The aim of this dissertation is to investigate the concept conceptual understanding in this professional domain, how it can be measured, what it looks like, how it changes, and in what ways it differs between students. The dissertation comprises five empirical studies for which data collection took place at a university of applied sciences in the Netherlands.
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In 'Ecodemocracy in the Wild: If existing democracies were to operationalize ecocentrism and animal ethics in policy-making, what would rewilding look like?' Helen Kopnina, Simon Leadbeater, Paul Cryer, Anja Heister, and Tamara Lewis present a democratic approach to considering the interests of entities and the correlation of rights of nature within it. According to the authors , ecodemocracy's overarching potential is to establish the baseline principles that dethrone single species domination and elevate multiple living beings as stakeholders in all decision-making. They provide insights on how ecodemocracy could become manifest and what it takes to achieve mult-species justice. A unique contribution in this chapter is the notion of ecodemocracy in rewilding , exemplified bij the controversial Dutch rewilding experiment in Oostvaardersplassen. The authors discuss the complexities of decision-making in the interest of different species and the challenges that arise when implementing such politics.
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This article discusses the viability of a feminist constructivist approach of knowledge through the careful reading of the work of the feminist scholar and historian of science and technology, Donna Haraway. Haraway proposes an interpretation of objectivity in terms of "situated knowledges". Both the subject and the object of knowledge are endowed with the status of material-semiotic actors. By blurring the epistemological boundary between subject and object, Haraway's narratives about scientific discourse become populated with hybrid subjects/objects. The author argues that the ethics of these hybrid subjects consists of an uneasy mixture of a Nietzschean and a socialist-Christian ethic. The article concludes by setting out why Haraway's project constitutes an interesting effort to fuse postmodern insights and feminist commitments.
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The Best Practice Unit (BPU) model constitutes a unique form of practice-based research. A variant of the Community of Practice model developed by Wenger, McDermott and Snyder (2002), the BPU has the specific aim of improving professional practice by combining innovation and research. The model is used as a way of working by a group of professionals, researchers and other relevant individuals, who over a period of one to two years, work together towards a desired improvement. The model is characterized by interaction between individual and collective learning processes, the development of new or improved working methods, and the implementation of these methods in daily practice. Multiple knowledge resources are used, including experiential knowledge, professional knowledge and scientific knowledge. The research serves diverse purposes: articulating tacit knowledge, documenting learning and innovation processes, systematically describing the working methods that have been revealed or developed, and evaluating the efficacy of the new methods. Each BPU is supported by a facilitator, whose main task is to optimize learning processes. An analysis of ten different BPUs in different professional fields shows that this is a successful model. The article describes the methodology and results of this study.
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Presented at the 14th 14th European Conference on Management, Leadership and Governance ECMLG 2018: From the article: "Abstract: Scientific literature and practices emphasize that organizations have to align their business strategies with their IT strategy. Strategic alignment of business with IT in organizations is not only a prerequisite for organizations to be successful or competitive but also positively influences IT effectiveness and leads to greater profitability. At the same time organizations have been struggling for a long time with the concept of strategic alignment. In this paper an enhanced concept of strategic alignment is given in such a way that organizations can practically use to align their business and IT. Based on scientific research in this study the existing concept of strategic alignment model, i.e. the relationship between business and IT, was enhanced by placing the discipline of information management between business and IT and thus making information management responsible for the alignment or linking of business with IT. This conceptually enhanced concept of strategic alignment was practically enhanced even further with the use of the Business information Service Library (BiSL) framework. This framework links business with IT on the strategically, managing and operational level of an organization. The BiSL process framework thus provides an description of the information management processes on the different levels of an organization that have to be implemented and carried out to achieve strategic alignment within an organization. With the support of three experts in the field of information management and BiSL, an enhanced Strategic Alignment Model was constructed. To validate this model 25 semi-structured interviews were conducted in eleven organizations. The results of these interviews show not only a strong and solid support for adding information management to the existing concept of strategic alignment but also indicate a strong and solid support for the use of the BiSL framework for implementing information management. These findings support the notion that the BiSL enhanced Strategic Alignment Model not only provides a conceptually enhanced strategic alignment model but also provides organizations with a concept of strategic alignment that organization can practically use to align their business with IT."
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The role of smart cities in order to improve older people’s quality of life, sustainability and opportunities, accessibility, mobility, and connectivity is increasing and acknowledged in public policy and private sector strategies in countries all over the world. Smart cities are one of the technological-driven initiatives that may help create an age-friendly city. Few research studies have analysed emerging countries in terms of their national strategies on smart or age-friendly cities. In this study, Romania which is predicted to become one of the most ageing countries in the European Union is used as a case study. Through document analysis, current initiatives at the local, regional, and national level addressing the issue of smart and age-friendly cities in Romania are investigated. In addition, a case study is presented to indicate possible ways of the smart cities initiatives to target and involve older adults. The role of different stakeholders is analysed in terms of whether initiatives are fragmentary or sustainable over time, and the importance of some key factors, such as private–public partnerships and transnational bodies. The results are discussed revealing the particularities of the smart cities initiatives in Romania in the time frame 2012–2020, which to date, have limited connection to the age-friendly cities agenda. Based on the findings, a set of recommendations are formulated to move the agenda forward. CC-BY Original article: https://doi.org/10.3390/ijerph17145202 (This article belongs to the Special Issue Feature Papers "Age-Friendly Cities & Communities: State of the Art and Future Perspectives") https://www.dehaagsehogeschool.nl/onderzoek/lectoraten/details/urban-ageing#over-het-lectoraat
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Comprehensive understanding of the merits of bottom-up urban development is lacking, thus hampering and complicating associated collaborative processes. Therefore, and given the assumed relevancies, we mapped the social, environmental and economic values generated by bottom-up developments in two Dutch urban areas, using theory-based evaluation principles. These evaluations raised insights into the values, beneficiaries and path dependencies between successive values, confirming the assumed effect of placemaking accelerating further spatial developments. It also revealed broader impacts of bottom-up endeavors, such as influences on local policies and innovations in urban development.
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