Knee joint instability is frequently reported by patients with knee osteoarthritis (KOA). Objective metrics to assess knee joint instability are lacking, making it difficult to target therapies aiming to improve stability. Therefore, the aim of this study was to compare responses in neuromechanics to perturbations during gait in patients with self-reported knee joint instability (KOA-I) versus patients reporting stable knees (KOA-S) and healthy control subjects.Forty patients (20 KOA-I and 20 KOA-S) and 20 healthy controls were measured during perturbed treadmill walking. Knee joint angles and muscle activation patterns were compared using statistical parametric mapping and discrete gait parameters. Furthermore, subgroups (moderate versus severe KOA) based on Kellgren and Lawrence classification were evaluated.Patients with KOA-I generally had greater knee flexion angles compared to controls during terminal stance and during swing of perturbed gait. In response to deceleration perturbations the patients with moderate KOA-I increased their knee flexion angles during terminal stance and pre-swing. Knee muscle activation patterns were overall similar between the groups. In response to sway medial perturbations the patients with severe KOA-I increased the co-contraction of the quadriceps versus hamstrings muscles during terminal stance.Patients with KOA-I respond to different gait perturbations by increasing knee flexion angles, co-contraction of muscles or both during terminal stance. These alterations in neuromechanics could assist in the assessment of knee joint instability in patients, to provide treatment options accordingly. Furthermore, longitudinal studies are needed to investigate the consequences of altered neuromechanics due to knee joint instability on the development of KOA.
The assessment of the out-of-plane response of unreinforced masonry (URM) buildings with cavity walls has been a popular topic in regions such as Central and Northern Europe, Australia, New Zealand, China and several other countries.Cavity walls are particularly vulnerable as the out-of-plane capacity of each individual leaf is significantly smaller than the one of a solid wall. In the Netherlands, cavity walls are characterized by an inner load-bearing leaf of calcium silicate bricks, and by an outer veneer of clay bricks that has only aesthetic and insulation functions. The two leaves are typically connected by means of metallic ties. This paper utilizes the results of an experimental campaign conducted by the authors to calibrate a hysteretic model that represents the axial cyclic response of cavity wall tie connections. The proposednumerical model uses zero-length elements implemented in OpenSees with the Pinching4 constitutive model to account for the compression-tension cyclic behaviour of the ties. The numerical model is able to capture important aspects of the tie response such as the strength degradation, the unloading stiffness degradation and the pinching behaviour. The numerical modelling approach in this paper can be easily adopted by practitioner engineers who aim to model the wall ties more accurately when assessing the structures against earthquakes.
The subject of this textbook is a methodical approach on the complex problem-solving process of conceptual structural design, leading to a controlled build-up of insight into the behaviour of the structure and supporting the actual successive design decisions during the conceptual design phase on the basis of a coherent set of solution components.
