Conference proceedings International Symposium on Intelligent Manufacturing Environments
From the article: Abstract—By using agent technology, a versatile and modular monitoring system can be built. In this paper, such a multiagentbased monitoring system will be described. The system can be trained to detect several conditions in combination and react accordingly. Because of the distributed nature of the system, the concept can be used in many situations, especially when combinations of different sensor inputs are used. Another advantage of the approach presented in this paper is the fact that every monitoring system can be adapted to specific situations. As a case-study, a health monitoring system will be presented.
Insulin sensitivity and metabolic flexibility decrease in response to bed rest, but the temporal and causal adaptations in human skeletal muscle metabolism are not fully defined. Here, we use an integrative approach to assess human skeletal muscle metabolism during bed rest and provide a multi-system analysis of how skeletal muscle and the circulatory system adapt to short- and long-term bed rest (German Clinical Trials: DRKS00015677). We uncover that intracellular glycogen accumulation after short-term bed rest accompanies a rapid reduction in systemic insulin sensitivity and less GLUT4 localization at the muscle cell membrane, preventing further intracellular glycogen deposition after long-term bed rest. We provide evidence of a temporal link between the accumulation of intracellular triglycerides, lipotoxic ceramides, and sphingomyelins and an altered skeletal muscle mitochondrial structure and function after long-term bed rest. An intracellular nutrient overload therefore represents a crucial determinant for rapid skeletal muscle insulin insensitivity and mitochondrial alterations after prolonged bed rest.
