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Comparing mixed-media and conventional slow-sand filters for arsenic removal from groundwater

Arsenic contamination of groundwater is a major public health concern worldwide. The problem has been reported mainly in southern Asia and, especially, in Bangladesh. Slow-sand filters (SSF) augmented with iron were proven to be a simple, low-cost and decentralized technique for the treatment of arsenic-contaminated sources. In this research, three pilot-scale SSF (flowrate 6 L·h−1) were tested regarding their capability of removing arsenic from groundwater in conditions similar to those found in countries like Bangladesh (70 µg As(III) L−1, 26 °C). From the three, two filters were prepared with mixed media, i.e., sand mixed with corrosive iron matter (CIM filter) and iron-coated sand (ICS filter), and a third conventional SSF was used as a reference. The results obtained showed that the CIM filter could remove arsenic below the World Health Organization (WHO) guideline concentration of 10 µg·L−1, even for inlet concentrations above 150 µg·L−1. After 230 days of continuous operation the arsenic concentration in the effluent started increasing, indicating depletion or saturation of the CIM layer. The effluent arsenic concentration, however, never exceeded the Bangladeshi standard of 50 µg·L−1 throughout the whole duration of the experiments.

Physiotherapists Using the Biopsychosocial Model for Chronic Pain: Barriers and Facilitators - A scoping review

The use of the biopsychosocial model in primary care physiotherapy for chronic pain is far from the recommendations given in research and current guidelines. To understand why physiotherapists have difficulty implementing a biopsychosocial approach, more insight is needed on the barriers and facilitators. This scoping review aimed to investigate and map these barriers and facilitators that physiotherapists working in primary care reportedly face when treating patients with chronic musculoskeletal pain from a biopsychosocial perspective. Four electronic databases (PubMed, Embase, CINAHL and ERIC) and the grey literature were searched. Studies were included if they investigated the experiences of physiotherapists in the treatment of chronic pain from a biopsychosocial perspective in primary care. Extracted data were discussed and sub grouped in themes following a qualitative content analysis approach. To align with current use of theories on behavior change, the resulting themes were compared to the Theoretical Domains Framework. After screening, twenty-four studies were included. Eight groups of barriers and facilitators were identified, thematically clustered in six themes: knowledge, skills, and attitudes; environmental context and resources; role clarity; confidence; therapeutic alliance; and patient expectations. The results of this review can be used to inform the development of implementation programs.

Rotatable Smart TinyLab, a platform for testing integrated façades and indoor climate

Cross-Border Business Development in the Dutch-German Borderland

Like a marker pen on a map, the Covid-19 pandemic drastically highlighted the persisting existence of borders that used to play an ever decreasing role in people´s perception and behavior over the last decades. Yes, inner European borders are open in normal times. Yes, people, goods, services and ideas are crossing the border between Germany and the Netherlands freely. Yet we see that the border can turn into a barrier again quickly and effectively and it does so in many dimensions, some of them being not easily visible. Barriers hinder growth, development and exchange and in spite of our progress in creating a borderless Europe, borders still create barriers in many domains. Differing labor law, social security and tax systems, heterogeneous education models, small and big cultural differences, language barriers and more can impose severe limitations on people and businesses as they cross the border to travel, shop, work, hire, produce, buy, sell, study and research. Borders are of all times and will therefore always exist. But as they did so for a long time, huge opportunities can be found in overcoming the barriers they create. The border must not necessarily be a dividing line between two systems. It has the potential to become a center of growth and progress that build on joint efforts, cross-border cooperation, mutual learning and healthy competition. Developing this inherent potential of border regions asks for politics, businesses and research & education on both sides of the border to work together. The research group Cross-Border Business Development at Fontys University of Applied Science in Venlo conducts applied research on the impact of the national border on people and businesses in the Dutch-German border area. Students, employees, border commuters, entrepreneurs and employers all face opportunities as well as challenges due to the border. In collaboration with these stakeholders, the research chair aims to create knowledge and provide solutions towards a Dutch-German labor market, an innovative Dutch-German borderland and a futureproof Cross-Border economic ecosystem. This collection is not about the borderland in times of COVID-19. Giving meaning to the borderland is an ongoing process that started long before the pandemic and will continue far beyond. The links that have been established across the border and those that will in the future are multifaceted and so are the topics in this collection. Vincent Pijnenburg outlines a broader and introductory perspective on the dynamics in the Dutch-German borderland.. Carla Arts observes shopping behavior of cross-border consumers in the Euregion Rhine-Meuse-North. Jan Lucas explores the interdependencies of the Dutch and German economies. Jean Louis Steevensz presents a cross-border co-creation servitization project between a Dutch supplier and a German customer. Vincent Pijnenburg and Patrick Szillat analyze the exitence of clusters in the Dutch-German borderland. Christina Masch and Janina Ulrich provide research on students job search preferences with a focus on the cross-border labor market. Sonja Floto-Stammen and Natalia Naranjo-Guevara contribute a study of the market for insect-based food in Germany and the Netherlands. Niklas Meisel investigates the differences in the German and Dutch response to the Covid-19 crisis. Finally, Tolga Yildiz and Patrick Szillat show differences in product-orientation and customer-orientation between Dutch and German small and medium sized companies. This collection shows how rich and different the links across the border are and how manifold the perspectives and fields for a cross-border approach to regional development can be. This publication is as well an invitation. Grasping the opportunities that the border location entails requires cooperation across professional fields and scientific disciplines, between politics, business and researchers. It needs the contact with and the contribution of the people in the region. So do what we strive for with our cross-border research agenda: connect!

Effect of physical exercise on the hippocampus and global grey matter volume in breast cancer patients

BackgroundPhysical exercise in cancer patients is a promising intervention to improve cognition and increase brain volume, including hippocampal volume. We investigated whether a 6-month exercise intervention primarily impacts total hippocampal volume and additionally hippocampal subfield volumes, cortical thickness and grey matter volume in previously physically inactive breast cancer patients. Furthermore, we evaluated associations with verbal memory.MethodsChemotherapy-exposed breast cancer patients (stage I-III, 2–4 years post diagnosis) with cognitive problems were included and randomized in an exercise intervention (n = 70, age = 52.5 ± 9.0 years) or control group (n = 72, age = 53.2 ± 8.6 years). The intervention consisted of 2x1 hours/week of supervised aerobic and strength training and 2x1 hours/week Nordic or power walking. At baseline and at 6-month follow-up, volumetric brain measures were derived from 3D T1-weighted 3T magnetic resonance imaging scans, including hippocampal (subfield) volume (FreeSurfer), cortical thickness (CAT12), and grey matter volume (voxel-based morphometry CAT12). Physical fitness was measured with a cardiopulmonary exercise test. Memory functioning was measured with the Hopkins Verbal Learning Test-Revised (HVLT-R total recall) and Wordlist Learning of an online cognitive test battery, the Amsterdam Cognition Scan (ACS Wordlist Learning). An explorative analysis was conducted in highly fatigued patients (score of ≥ 39 on the symptom scale ‘fatigue’ of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire), as previous research in this dataset has shown that the intervention improved cognition only in these patients.ResultsMultiple regression analyses and voxel-based morphometry revealed no significant intervention effects on brain volume, although at baseline increased physical fitness was significantly related to larger brain volume (e.g., total hippocampal volume: R = 0.32, B = 21.7 mm3, 95 % CI = 3.0 – 40.4). Subgroup analyses showed an intervention effect in highly fatigued patients. Unexpectedly, these patients had significant reductions in hippocampal volume, compared to the control group (e.g., total hippocampal volume: B = −52.3 mm3, 95 % CI = −100.3 – −4.4)), which was related to improved memory functioning (HVLT-R total recall: B = −0.022, 95 % CI = −0.039 – −0.005; ACS Wordlist Learning: B = −0.039, 95 % CI = −0.062 – −0.015).ConclusionsNo exercise intervention effects were found on hippocampal volume, hippocampal subfield volumes, cortical thickness or grey matter volume for the entire intervention group. Contrary to what we expected, in highly fatigued patients a reduction in hippocampal volume was found after the intervention, which was related to improved memory functioning. These results suggest that physical fitness may benefit cognition in specific groups and stress the importance of further research into the biological basis of this finding.