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Noise vs. control

Over many years we’ve been looking at the emergence of “organized networks” as an alternative concept that could counter the social media platform a priori of gathering (and then exploiting) “weak links.”[1] Organized networks invent new institutional forms whose dynamics, properties, and practices are internal to the operational logic of communication media and digital technologies. Their emergence is prompted, in part, by a wider social fatigue with and increasing distrust of traditional and modern institutions such as the church, political party, firm, and labour union, which maintain hierarchical modes of organization. While not without hierarchical tendencies (founders, technical architectures, centralized infrastructures, personality cults), organized networks tend to gravitate more strongly toward horizontal modes of communication, practice, and planning.

Here and now?

Urgent publishing pertains both to timeliness and relevance. What strategies are available to publishers in the cultural and research domains to conceive, produce, and position their contents in an urgent way? Revolving around the key notions of relations, trust, and remediation, Here and Now? Explorations in Urgent Publishing presents methods and prototypes that counter the contemporary speedy information sphere in new and different ways. It develops a situated account of hybrid publishing, where authors, editors, publishers, designers, and readers operate together.

The Swamps of Postart

‘Non art is more art than art art’, Allan Kaprow claimed in 1972. He concluded: ‘Artists of the world, drop out! You have nothing to lose but your professions.’ Are we ready to move on? From the 6th until the 9th of June 2024, an international group of art workers gathered at Floating Berlin to explore this question during the Konteksty Postartistic Congress.

Introduction

Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model

From teh UU repository: "Background: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and long-term efficacy. The use of non-digestible oligosaccharides might improve OIT efficacy since they are known to directly modulate intestinal epithelial and immune cells in addition to acting as prebiotics. Aim: To investigate whether a diet supplemented with plant-derived fructo-oligosaccharides (FOS) supports the efficacy of OIT in a murine cow's milk allergy model and to elucidate the potential mechanisms involved. Methods: After oral sensitization to the cow's milk protein whey, female C3H/HeOuJ mice were fed either a control diet or a diet supplemented with FOS (1% w/w) and received OIT (10 mg whey) 5 days a week for 3 weeks by gavage. Intradermal (i.d.) and intragastric (i.g.) challenges were performed to measure acute allergic symptoms and mast cell degranulation. Blood and organs were collected to measure antibody levels and T cell and dendritic cell populations. Spleen-derived T cell fractions (whole spleen-and CD25-depleted) were transferred to naive recipient mice to confirm the involvement of regulatory T cells (Tregs) in allergy protection induced by OIT + FOS. Results: OIT + FOS decreased acute allergic symptoms and mast cell degranulation upon challenge and prevented the challenge-induced increase in whey-specific IgE as observed in sensitized mice. Early induction of Tregs in the mesenteric lymph nodes (MLN) of OIT + FOS mice coincided with reduced T cell responsiveness in splenocyte cultures. CD25 depletion in OIT + FOS-derived splenocyte suspensions prior to transfer abolished protection against signs of anaphylaxis in recipients. OIT + FOS increased serum galectin-9 levels. No differences in short-chain fatty acid (SCFA) levels in the cecum were observed between the treatment groups. Concisely, FOS supplementation significantly improved OIT in the acute allergic skin response, %Foxp3+ Tregs and %LAP+ Th3 cells in MLN, and serum galectin-9 levels. Conclusion: FOS supplementation improved the efficacy of OIT in cow's milk allergic mice. Increased levels of Tregs in the MLN and abolished protection against signs of anaphylaxis upon transfer of CD25-depleted cell fractions, suggest a role for Foxp3+ Tregs in the protective effect of OIT + FOS. "

Biodiversity conservation in climate change driven transient communities

Species responding differently to climate change form ‘transient communities’, communities with constantly changing species composition due to colonization and extinction events. Our goal is to disentangle the mechanisms of response to climate change for terrestrial species in these transient communities and explore the consequences for biodiversity conservation. We review spatial escape and local adaptation of species dealing with climate change from evolutionary and ecological perspectives. From these we derive species vulnerability and management options to mitigate effects of climate change. From the perspective of transient communities, conservation management should scale up static single species approaches and focus on community dynamics and species interdependency, while considering species vulnerability and their importance for the community. Spatially explicit and frequent monitoring is vital for assessing the change in communities and distribution of species. We review management options such as: increasing connectivity and landscape resilience, assisted colonization, and species protection priority in the context of transient communities.