Background & aims: Accurate diagnosis of sarcopenia requires evaluation of muscle quality, which refers to the amount of fat infiltration in muscle tissue. In this study, we aim to investigate whether we can independently predict mortality risk in transcatheter aortic valve implantation (TAVI) patients, using automatic deep learning algorithms to assess muscle quality on procedural computed tomography (CT) scans. Methods: This study included 1199 patients with severe aortic stenosis who underwent transcatheter aortic valve implantation (TAVI) between January 2010 and January 2020. A procedural CT scan was performed as part of the preprocedural-TAVI evaluation, and the scans were analyzed using deep-learning-based software to automatically determine skeletal muscle density (SMD) and intermuscular adipose tissue (IMAT). The association of SMD and IMAT with all-cause mortality was analyzed using a Cox regression model, adjusted for other known mortality predictors, including muscle mass. Results: The mean age of the participants was 80 ± 7 years, 53% were female. The median observation time was 1084 days, and the overall mortality rate was 39%. We found that the lowest tertile of muscle quality, as determined by SMD, was associated with an increased risk of mortality (HR 1.40 [95%CI: 1.15–1.70], p < 0.01). Similarly, low muscle quality as defined by high IMAT in the lowest tertile was also associated with increased mortality risk (HR 1.24 [95%CI: 1.01–1.52], p = 0.04). Conclusions: Our findings suggest that deep learning-assessed low muscle quality, as indicated by fat infiltration in muscle tissue, is a practical, useful and independent predictor of mortality after TAVI.
As every new generation of civil aircraft creates more on-wing data and fleets gradually become more connected with the ground, an increased number of opportunities can be identified for more effective Maintenance, Repair and Overhaul (MRO) operations. Data are becoming a valuable asset for aircraft operators. Sensors measure and record thousands of parameters in increased sampling rates. However, data do not serve any purpose per se. It is the analysis that unleashes their value. Data analytics methods can be simple, making use of visualizations, or more complex, with the use of sophisticated statistics and Artificial Intelligence algorithms. Every problem needs to be approached with the most suitable and less complex method. In MRO operations, two major categories of on-wing data analytics problems can be identified. The first one requires the identification of patterns, which enable the classification and optimization of different maintenance and overhaul processes. The second category of problems requires the identification of rare events, such as the unexpected failure of parts. This cluster of problems relies on the detection of meaningful outliers in large data sets. Different Machine Learning methods can be suggested here, such as Isolation Forest and Logistic Regression. In general, the use of data analytics for maintenance or failure prediction is a scientific field with a great potentiality. Due to its complex nature, the opportunities for aviation Data Analytics in MRO operations are numerous. As MRO services focus increasingly in long term contracts, maintenance organizations with the right forecasting methods will have an advantage. Data accessibility and data quality are two key-factors. At the same time, numerous technical developments related to data transfer and data processing can be promising for the future.
Loneliness among young adults is a growing concern worldwide, posing serious health risks. While the human ecological framework explains how various factors such as socio-demographic, social, and built environment characteristics can affect this feeling, still, relatively little is known about the effect of built environment characteristics on the feelings of loneliness that young people experience in their daily life activities. This research investigates the relationship between built environment characteristics and emotional state loneliness in young adults (aged 18–25) during their daily activities. Leveraging the Experience Sampling Method, we collected data from 43 participants for 393 personal experiences during daily activities across different environmental settings. The findings of a mixed-effects regression model reveal that built environment features significantly impact emotional state loneliness. Notably, activity location accessibility, social company during activities, and walking activities all contribute to reducing loneliness. These findings can inform urban planners and municipalities to implement interventions that support youngsters’ activities and positive experiences to enhance well-being and alleviate feelings of loneliness in young adults. Specific recommendations regarding the built environment are (1) to create spaces that are accessible, (2) create spaces that are especially accessible by foot, and (3) provide housing with shared facilities for young adults rather than apartments/studios.
