For long flights, the cruise is the longest phase and where the largest amount of fuel is consumed. An in-cruise optimization method has been implemented to calculate the optimal trajectory that reduces the flight cost. A three-dimensional grid has been created, coupling lateral navigation and vertical navigation profiles. With a dynamic analysis of the wind, the aircraft can perform a horizontal deviation or change altitudes via step climbs to reduce fuel consumption. As the number of waypoints and possible step climbs is increased, the number of flight trajectories increases exponentially; thus, a genetic algorithm has been implemented to reduce the total number of calculated trajectories compared to an exhaustive search. The aircraft’s model has been obtained from a performance database, which is currently used in the commercial flight management system studied in this paper. A 5% average flight cost reduction has been obtained.
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Aircraft require significant quantities of fuel in order to generate the power required to sustain a flight. Burning this fuel causes the release of polluting particles to the atmosphere and constitutes a direct cost attributed to fuel consumption. The optimization of various aircraft operations in different flight phases such as cruise and descent, as well as terminal area movements, have been identified as a way to reduce fuel requirements, thus reducing pollution. The goal of this chapter is to briefly explain and apply different metaheuristic optimization algorithms to improve the cruise flight phase cost in terms of fuel burn. Another goal is to present an overview of the most popular commercial aircraft models. The algorithms implemented for different optimization strategies are genetic algorithms, the artificial bee colony, and the ant colony algorithm. The fuel burn aircraft model used here is in the form of a Performance Database. A methodology to create this model using a Level D aircraft research flight simulator is briefly explained. Weather plays an important role in flight optimization, and so this work explains a method for incorporating open source weather. The results obtained for the optimization algorithms show that every optimization algorithm was able to reduce the flight consumption, thereby reducing the pollution emissions and contributing to airlines’ profit margins.
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A modified genetic algorithm (MGA) optimization procedure, alongside time series machine learning (ML) classifiers, is proposed to minimize handovers in a digital twin-based visible light communication (VLC) system. Frequent handovers have a direct impact on the overall performance of the VLC system due to the inherent connection downtime of a handover process. The handover scheme proposed in this article considers the receiver trajectory information to minimize handovers, maintaining the system performance below the forward error correction limit. Simulation results indicate that the proposed scheme outperforms a power-based handover scheme, achieving handover reductions of 42.47%. Therefore, the MGA combined to the ML models approach is an effective means of minimizing handovers, as well as improving overall VLC system performance.
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Om inzicht te krijgen in spierveroudering is genexpressie gemeten in vastus lateralis biopten van jonge en oude mannen en vrouwen. We vonden dat tijdens het ouder worden bij beide geslachten dezelfde categorieën genen in spieren worden aan- en uitgeschakeld (“gereguleerd”); de mate van deze zogenaamde differentiële expressie was echter geslachtsspecifiek. Bij mannen was oxidatieve fosforylering het meest in het oog springende proces, en bij vrouwen was dit celgroei gemedieerd door AKT-signalering. De conclusie is dat dezelfde processen zijn geassocieerd met skeletspierveroudering bij mannen en vrouwen, maar dat de differentiële expressie van die processen geslachtsspecifiek is.
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Mathematics teacher educators in primary teacher education need expert knowledge and skills in teaching in primary school, in subject matter and research. Most starting mathematics teacher educators possess only part of this knowledge and skills. A professional development trajectory for this group is developed and tested, where a design based research is used to evaluate the design. This paper describes the professional development trajectory and design. We conclude that the professional development design should focus on mathematical knowledge for teaching, should refer to both teacher education and primary education, should offer opportunities for cooperative learning, and need to use practice based research as a developmental tool.
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In this paper, artificial intelligence tools are implemented in order to predict trajectory positions, as well as channel performance of an optical wireless communications link. Case studies for industrial scenarios are considered to this aim. In a first stage, system parameters are optimized using a hybrid multi-objective optimization (HMO) procedure based on the grey wolf optimizer and the non-sorting genetic algorithm III with the goal of simultaneously maximizing power and spectral efficiency. In a second stage, we demonstrate that a long short-term memory neural network (LSTM) is able to predict positions, as well as channel gain. In this way, the VLC links can be configured with the optimal parameters provided by the HMO. The success of the proposed LSTM architectures was validated by training and test root-mean square error evaluations below 1%.
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Longitudinal criminological studies greatly improved our understanding of the longitudinal patterns of criminality. These studies, however, focused almost exclusively on traditional types of offending and it is therefore unclear whether results are generalizable to online types of offending. This study attempted to identify the developmental trajectories of active hackers who perform web defacements. The data for this study consisted of 2,745,311 attacks performed by 66,553 hackers and reported to Zone-H between January 2010 and March 2017. Semi-parametric group-based trajectory models were used to distinguish six different groups of hackers based on the timing and frequency of their defacements. The results demonstrated some common relationships to traditional types of crime, as a small population of defacers accounted for the majority of defacements against websites. Additionally, the methods and targeting practices of defacers differed based on the frequency with which they performed defacements generally.
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Introduction: The implementation of oncology care pathways that standardize organizational procedures has improved cancer care in recent years. However, the involvement of “authentic” patients and caregivers in quality improvement of these predetermined pathways is in its infancy, especially the scholarly reflection on this process. We, therefore, aim to explore the multidisciplinary challenges both in practice, when cancer patients, their caregivers, and a multidisciplinary team of professionals work together on quality improvement, as well as in our research team, in which a social scientist, health care professionals, health care researchers, and experience experts design a research project together. Methods and design: Experience-based co-design will be used to involve cancer patients and their caregivers in a qualitative research design. In-depth open discovery interviews with 12 colorectal cancer patients, 12 breast cancer patients, and seven patients with cancer-associated thrombosis and their caregivers, and focus group discussions with professionals from various disciplines will be conducted. During the subsequent prioritization events and various co-design quality improvement meetings, observational field notes will be made on the multidisciplinary challenges these participants face in the process of co-design, and evaluation interviews will be done afterwards. Similar data will be collected during the monthly meetings of our multidisciplinary research team. The data will be analyzed according to the constant comparative method. Discussion: This study may facilitate quality improvement programs in oncologic care pathways, by increasing our real-world knowledge about the challenges of involving “experience experts” together with a team of multidisciplinary professionals in the implementation process of quality improvement. Such co-creation might be challenging due to the traditional paternalistic relationship, actual disease-/treatment-related constraints, and a lack of shared language and culture between patients, caregivers, and professionals and between professionals from various disciplines. These challenges have to be met in order to establish equality, respect, team spirit, and eventual meaningful participation.
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The transition from home to a nursing home can be stressful and traumatic for both older persons and informal caregivers and is often associated with negative outcomes. Additionally, transitional care interventions often lack a comprehensive approach, possibly leading to fragmented care. To avoid this fragmentation and to optimize transitional care, a comprehensive and theory-based model is fundamental. It should include the needs of both older persons and informal caregivers. Therefore, this study, conducted within the European TRANS-SENIOR research consortium, proposes a model to optimize the transition from home to a nursing home, based on the experiences of older persons and informal caregivers. These experiences were captured by conducting a literature review with relevant literature retrieved from the databases CINAHL and PubMed. Studies were included if older persons and/or informal caregivers identified the experiences, needs, barriers, or facilitators during the transition from home to a nursing home. Subsequently, the data extracted from the included studies were mapped to the different stages of transition (pre-transition, mid-transition, and post-transition), creating the TRANSCITmodel. Finally, results were discussed with an expert panel, leading to a final proposed TRANSCIT model. The TRANSCIT model identified that older people and informal caregivers expressed an overall need for partnership during the transition from home to a nursing home. Moreover, it identified 4 key components throughout the transition trajectory (ie, pre-, mid-, and post-transition): (1) support, (2) communication, (3) information, and (4) time. The TRANSCIT model could advise policy makers, practitioners, and researchers on the development and evaluation of (future) transitional care interventions. It can be a guideline reckoning the needs of older people and their informal caregivers, emphasizing the need for a partnership, consequently reducing fragmentation in transitional care and optimizing the transition from home to a nursing home.
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Background and purpose The aim of this study is to investigate changes in movement behaviors, sedentary behavior and physical activity, and to identify potential movement behavior trajectory subgroups within the first two months after discharge from the hospital to the home setting in first-time stroke patients. Methods A total of 140 participants were included. Within three weeks after discharge, participants received an accelerometer, which they wore continuously for five weeks to objectively measure movement behavior outcomes. The movement behavior outcomes of interest were the mean time spent in sedentary behavior (SB), light physical activity (LPA) and moderate to vigorous physical activity (MVPA); the mean time spent in MVPA bouts ≥ 10 minutes; and the weighted median sedentary bout. Generalized estimation equation analyses were performed to investigate overall changes in movement behavior outcomes. Latent class growth analyses were performed to identify patient subgroups of movement behavior outcome trajectories. Results In the first week, the participants spent an average, of 9.22 hours (67.03%) per day in SB, 3.87 hours (27.95%) per day in LPA and 0.70 hours (5.02%) per day in MVPA. Within the entire sample, a small but significant decrease in SB and increase in LPA were found in the first weeks in the home setting. For each movement behavior outcome variable, two or three distinctive subgroup trajectories were found. Although subgroup trajectories for each movement behavior outcome were identified, no relevant changes over time were found. Conclusion Overall, the majority of stroke survivors are highly sedentary and a substantial part is inactive in the period immediately after discharge from hospital care. Movement behavior outcomes remain fairly stable during this period, although distinctive subgroup trajectories were found for each movement behavior outcome. Future research should investigate whether movement behavior outcomes cluster in patterns.
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