BackgroundPhysical exercise is an intervention that might protect against doxorubicin‐induced cardiotoxicity. In this meta‐analysis and systematic review, we aimed to estimate the effect of exercise on doxorubicin‐induced cardiotoxicity and to evaluate mechanisms underlying exercise‐mediated cardioprotection using (pre)clinical evidence.Methods and ResultsWe conducted a systematic search in PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) databases. Cochrane's and Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) risk‐of‐bias tools were used to assess the validity of human and animal studies, respectively. Cardiotoxicity outcomes reported by ≥3 studies were pooled and structured around the type of exercise intervention. Forty articles were included, of which 3 were clinical studies. Overall, in humans (sample sizes ranging from 24 to 61), results were indicative of exercise‐mediated cardioprotection, yet they were not sufficient to establish whether physical exercise protects against doxorubicin‐induced cardiotoxicity. In animal studies (n=37), a pooled analysis demonstrated that forced exercise interventions significantly mitigated in vivo and ex vivo doxorubicin‐induced cardiotoxicity compared with nonexercised controls. Similar yet slightly smaller effects were found for voluntary exercise interventions. We identified oxidative stress and related pathways, and less doxorubicin accumulation as mechanisms underlying exercise‐induced cardioprotection, of which the latter could act as an overarching mechanism.ConclusionsAnimal studies indicate that various exercise interventions can protect against doxorubicin‐induced cardiotoxicity in rodents. Less doxorubicin accumulation in cardiac tissue could be a key underlying mechanism. Given the preclinical evidence and limited availability of clinical data, larger and methodologically rigorous clinical studies are needed to clarify the role of physical exercise in preventing cardiotoxicity in patients with cancer.RegistrationURL: https://www.crd.york.ac.uk/prospero; Unique identifier: CRD42019118218.
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In this study, aviation, energy, exergy, environmental, exergoeconomic, and exergoenvironmental analyses are performed on a CFM56-3 series high by-pass turbofan engine fueled with Jet-A1 fuel. Specific fuel consumption and specific thrust of the engine are found to be 0.01098 kg/kN.s and 0.3178 kN/kg/s, respectively. Engine's energy efficiency is calculated as 35.37%, while waste energy ratio is obtained as 64.63%. Exergy efficiency, waste exergy rate, and fuel exergy waste ratio are forecasted as 33.32%, 33175.03 kW, and 66.68%, respectively. Environmental effect factor and ecological effect factor are computed as 2.001 and 3.001, while ecological objective function and its index are taken into account of −16597.22 kW and −1.001, respectively. Exergetic sustainability index and sustainable efficiency factor are determined as 0.5 and 1.5 for the CFM56-3 engine, respectively. Environmental damage cost rate is determined as 519.753 $/h, while the environmental damage cost index is accounted as 0.0314 $/kWh. Specific exergy cost of the engine production is found as 40.898 $/GJ from exergoeconomic analysis, while specific product exergy cost is expressed as 49.607 $/GJ from exergoenvironmental analysis. From exergoenvironmental economic analysis, specific exergy cost of fuel is computed as 10.103 $/GJ when specific exergy cost of production is determined as 40.898 $/GJ.
This paper outlines an investigation into the updating of fatigue reliability through inspection data by means of structural correlation. The proposed methodology is based on the random nature of fatigue fracture growth and the probability of damage detection and introduces a direct link between predicted crack size and inspection results. A distinct focus is applied on opportunities for utilizing inspection information for the updating of both inspected and uninspected (or uninspectable) locations.
Nowadays, there is particular attention towards the recycling of waste materials which is a critical issue for environmental protection and waste management. Polymer materials have numerous applications in daily life products. As a result, plastic pollution has become one of the biggest threats to nature, therefore recycling or replacing them with bio-based materials can significantly help the ecosystems. So far, many studies have investigated the possibility of reusing plastic waste, as a second life, to obtain consumable products. The 3D printing market is one of the great sectors that can utilize a wide range of thermoplastic polymers. This technology provides a unique capability to produce complex shape structures and products that cannot be produced by other manufacturing processes. In particular, Fused Filament Fabrication (FFF) is a common printing technology that consumes thermoplastic filaments including recycled materials. This printing technique has been also very successful in using novel high-performance materials with sustainable aspects. The reSHAPE project aims to develop novel smart filaments, with shape memory properties, from recycled materials. The filaments can be applied for the design and fabrication of smart products with dynamic behavior. In particular, the fabricated parts can shift from a plastic-deformed shape into a recovered original shape when being triggered by an external stimulus, like temperature. For that, we will specifically apply recycled polylactic acid (PLA) and thermoplastic polyurethane (TPU) as the main materials in this study. Because they both have proper shape memory properties and also TPU can potentially enhance the material flexibility which is required in the design and fabrication of functional components. As a result, this study will obtain a proper combination of these materials with good printability and functionality that can be used for a wide range of products from the aerospace and automotive sectors to soft robotics and medical devices.