from the article: "Abstract: The oral mucosa is the first immune tissue that encounters allergens upon ingestion of food. We hypothesized that the bio-accessibility of allergens at this stage may be a key determinant for sensitization. Light roasted peanut flour was suspended at various pH in buffers mimicking saliva. Protein concentrations and allergens profiles were determined in the supernatants. Peanut protein solubility was poor in the pH range between 3 and 6, while at a low pH (1.5) and at moderately high pHs (>8), it increased. In the pH range of saliva, between 6.5 and 8.5, the allergens Ara h2 and Ara h6 were readily released, whereas Ara h1 and Ara h3 were poorly released. Increasing the pH from 6.5 to 8.5 slightly increased the release of Ara h1 and Ara h3, but the recovery remained low (approximately 20%) compared to that of Ara h2 and Ara h6 (approximately 100% and 65%, respectively). This remarkable difference in the extraction kinetics suggests that Ara h2 and Ara h6 are the first allergens an individual is exposed to upon ingestion of peanut-containing food. We conclude that the peanut allergens Ara h2 and Ara h6 are quickly bio-accessible in the mouth, potentially explaining their extraordinary allergenicity."
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Dit artikel is een vertaling van Steyaert, J. (2005). Web based higher education, the inclusion/exclusion paradox. Journal of technology in human services, 23(1/2), 67-78. Het beschrijft de relatie tussen e-learning en toegankelijkheid voor studenten met een functionele beperking.
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Hoe meer data er beschikbaar komt, des te meer de beslissing verbeterd kan worden. Hoe beter (slimmer) de beslissing wordt gemaakt, des te meer waarde de beslissing heeft voor uw organisatie. Dit wordt het data-netwerk-effect genoemd. Vaak wordt het data-netwerk-effect gerealiseerd door het gebruik van data van onbewuste data-donoren. In dit artikel wordt een ander soort data-donor belicht: de bewuste data-donor.
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Lokaal voedsel heeft vele voordelen, zoals het verbinden van producenten consument, een mogelijke vermindering van voedselkilometers en een meer vanzelfsprekend seizoensgebonden dieet. In dit essay beargumenteert Esther Veen echter dat we het begrip ‘lokaal’ te eenzijdig benaderen, waardoor we het niet ten volle benutten. Als we het over lokaal hebben, gaat het immers vaak over korte ketens tussen boer en burger, of over mensen die hun eigen eten verbouwen. Zonder het belang van dat soort initiatieven te willen bagatelliseren, is het belangrijk om te beseffen dat het bereik ervan relatief beperkt is. Daarom stelt ze voor om te inventariseren wat de stedeling van vandaag lokaal geproduceerd zou willen zien, en om te proberen daarbij aan te sluiten. Omdat de Flevolandse stedelijke bevolking erg divers is, kan dat betekenen dat we verder moeten kijken dan lokaal geproduceerde aardappelen en wortelen, en ons moeten richten op lokale sopropo, vissaus en tempeh.
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Bio-based and circular building materials and techniques can play an important role in the transition toward a more sustainable construction sector. This study focuses on the Northern Netherlands and explores those competencies (in terms of knowledge, skills, and attitude) required by construction workers to meet thechallenges of material transition. The perspectives on this topic of construction companies, vocational education institutions, and local networking initiatives have been collected and analyzed by using the thematic analysis method. The results indicate that the limited knowledge availability, combined with the restricted experimentation possibilities, shape the current experiences, as well as the positioning of these stakeholders, regarding the desired competencies of construction workers. It is found that mainly attitudinal aspects of the construction workers need to receive particular attention and prioritization. To achieve that, the results highlight the importance of knowledge exchange and awareness-raising initiatives, as well as the development of a flexible, regional, and comprehensive learning environment.
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Plastic is one of the biggest contributors to pollution of the planet. Due to the low recyclability of oil-based plastics, most plastic is being disposed into the environment. According to plastic oceans, 10 million tons of plastic are dumped into oceans annually. Currently, researchers are developing recycling methods for oil-based plastics and are looking for biobased alternatives. One of these alternatives are a class of polymers called polyhydroxyalkanoates (PHA’s). PHA’s differ from other biobased polymers, due to the process of fabrication. PHA’s are a natural polymer, acting as an energy and carbon storage for different strains of bacteria. Functioning as an energy storage, nature can break down PHA’s and PHA-based waste. (1) Different companies are working on PHA’s production, but a large deviations in physical properties were observed. This research aims to establish a relationship between the chemical and physical properties of the different PHA’s, using gel permeability chromatography (GPC), nuclear magnetic resonance (NMR) and gas chromatography-mass spectroscopy (GC-MS).
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(Book of abstracts)Track (1) Space: Built Environment and Urban DesignAbstract:In light of the ongoing environmental, climate, economic, and social crises, citymaking agents of all disciplines are rethinking the (design of the) built environment with an emphasis on sustainability and inclusivity. While uncertainty and technocratic processes are prevalent, they also present opportunities to explore future scenarios and recognise the proactive role of change in transformative processes. The concept of ‘adaptivity’, across various design phases and scales, offers a potential approach for envisioning future urban strategies. This paper takes an integral approach to examine the different facets of adaptivity and its application in research and design. By addressing the multi-dimensional nature of space and time, this design approach can support the development of diverse methodologies to tackle urgent circular, economic, climate, and social transitions. Moreover, by revisiting existing theories through a review of literature and case studies, the paper positions them within today’s context and proposes new concepts that go beyond traditional frameworks. Ultimately, this paper seeks to enhance our understanding of adaptivity in the built environment, through research and student design projects developed in The Netherlands where its principles are used to respond to changing conditions, showing a thorough collaboration across research, education, and practice.
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There is a growing number of eHealth interventionsaiming at enhancing lifestyle to address obesity. However, theexisting interventions do not take the emotional aspects ofobesity into account. Forty percent of the overweight populationis an emotional eater. Emotional eaters gain weight because ofpoor emotion regulation, not just due to bad eating habits. Weaim at developing a personalised virtual coach ‘Denk je zèlf!’providing support for self-regulation of emotions for obeseemotional eaters. This paper presents a research study protocolon validating persuasive coaching strategies in emotionregulation, based on Dialectical Behaviour Therapy, ultimatelytargeting behaviour change. Our goal is to design a personalisedeCoaching framework, allowing us to optimally translatesuccessful behaviour change mechanisms and techniques, suchas dialectical strategies, into personalised persuasive coachingstrategies.
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Abstract Background One of the most problematic expression of ageing is frailty, and an approach based on its early identification is mandatory. The Sunfrail-tool (ST), a 9-item questionnaire, is a promising instrument for screening frailty. Aims • To assess the diagnostic accuracy and the construct validity between the ST and a Comprehensive Geriatric Assessment (CGA), composed by six tests representative of the bio-psycho-social model of frailty; • To verify the discriminating power of five key-questions of the ST; • To investigate the role of the ST in a clinical-pathway of falls’ prevention. Methods In this retrospective study, we enrolled 235 patients from the Frailty-Multimorbidity Lab of the University-Hospital of Parma. The STs’ answers were obtained from the patient’s clinical information. A patient was considered frail if at least one of the CGAs’ tests resulted positive. Results The ST was associated with the CGA’s judgement with an Area Under the Curve of 0.691 (CI 95%: 0.591–0.791). Each CGA’s test was associated with the ST total score. The five key-question showed a potential discriminating power in the CGA’s tests of the corresponding domains. The fall-related question of the ST was significantly associated with the Short Physical Performance Battery total score (OR: 0.839, CI 95%: 0.766–0.918), a proxy of the risk of falling. Discussion The results suggest that the ST can capture the complexity of frailty. The ST showed a good discriminating power, and it can guide a second-level assessment to key frailty domains and/or clinical pathways. Conclusions The ST is a valid and easy-to-use instrument for the screening of frailty.
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This upper-level Open Access textbook aims to educate students and professionals on how to develop business models that have a positive impact on people, society, and the social and ecological environment. It explores a different view of how to organize value creation, from a focus on an almost exclusively monetary value creation to one that creates positive impact through multiple values.The book offers students and entrepreneurs a structured approach based through the Business Model Template (BMT). It consists of three stages and ten building blocks to facilitate the development of a business model. Users, be they students or practitioners, need to choose from one of the three offered business model archetypes, namely the platform, community, or circular business models. Each archetype offers a dedicated logic for vale creation. The book can be used to develop a business model from scratch (turning an idea into a working prototype) or to transform an existing business model into one of the three archetypes. Throughout the book extra sources, links to relevant online video clips, assignments and literature are offered to facilitate the development process.This book will be of interest to students studying the development of business models, sustainable management, innovation, and value creation. It will also be of interest executives, and professionals such as consultants or social entrepreneurs seeking further education.
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