For almost fifteen years, the availability and regulatory acceptance of new approach methodologies (NAMs) to assess the absorption, distribution, metabolism and excretion (ADME/biokinetics) in chemical risk evaluations are a bottleneck. To enhance the field, a team of 24 experts from science, industry, and regulatory bodies, including new generation toxicologists, met at the Lorentz Centre in Leiden, The Netherlands. A range of possibilities for the use of NAMs for biokinetics in risk evaluations were formulated (for example to define species differences and human variation or to perform quantitative in vitro-in vivo extrapolations). To increase the regulatory use and acceptance of NAMs for biokinetics for these ADME considerations within risk evaluations, the development of test guidelines (protocols) and of overarching guidance documents is considered a critical step. To this end, a need for an expert group on biokinetics within the Organisation of Economic Cooperation and Development (OECD) to supervise this process was formulated. The workshop discussions revealed that method development is still required, particularly to adequately capture transporter mediated processes as well as to obtain cell models that reflect the physiology and kinetic characteristics of relevant organs. Developments in the fields of stem cells, organoids and organ-on-a-chip models provide promising tools to meet these research needs in the future.
MULTIFILE
Sustainable urban drainage systems (SuDS) or nature-based solutions (NBSs) are widely implemented to collect, store and infiltrate stormwater. The buildup of pollutants is expected in NBSs, and Dutch guidelines advise monitoring the topsoil of bio-swales every 5 years. In the Netherlands, almost every municipality has implemented bio-swales. Some municipalities have over 300 bio-swales, and monitoring all their NBSs is challenging due to cost and capacity. In this study, 20 locations where bio-swales with ages ranging between 10 and 20 years old were selected for a field investigation to answer the following question: is the soil quality of bio-swales after 10 years still acceptable? Portable XRF instruments were used to detect potential toxic elements (PTEs) for in situ measurements. The results showed that for copper (Cu), zinc (Zn) and lead (Pb), 30%, 40% and 25% of the locations show values above the threshold and 5%, 20% and 0% above the intervention threshold, meaning immediate action should be taken. The results are of importance for stakeholders in (inter)national cities that implement, maintain, and monitor NBS. Knowledge of stormwater and soil quality related to long-term health risks from NBS enables urban planners to implement the mostappropriate stormwater management strategies. With these research results, the Dutch guidelines for design, construction, and maintenance can be updated, and stakeholders are reminded that the monitoring of green infrastructure should be planned and executed every 5 years.
Bio-based and circular building materials and techniques can play an important role in the transition toward a more sustainable construction sector. This study focuses on the Northern Netherlands and explores those competencies (in terms of knowledge, skills, and attitude) required by construction workers to meet thechallenges of material transition. The perspectives on this topic of construction companies, vocational education institutions, and local networking initiatives have been collected and analyzed by using the thematic analysis method. The results indicate that the limited knowledge availability, combined with the restricted experimentation possibilities, shape the current experiences, as well as the positioning of these stakeholders, regarding the desired competencies of construction workers. It is found that mainly attitudinal aspects of the construction workers need to receive particular attention and prioritization. To achieve that, the results highlight the importance of knowledge exchange and awareness-raising initiatives, as well as the development of a flexible, regional, and comprehensive learning environment.
The textile industry faces a significant environmental challenge, annually generating 45 million tons of waste cotton textiles, of which 75% are incinerated or sent to landfills, causing environmental harm. Additionally, 67% of garments are made of plastic fibers, and when disposed of in landfills, 5% of them turn into microplastics that can end up on our plates. Chicfashic proposes an innovative biotech process to address these issues by recovering and recycling plastic fibers while transforming natural fibers into bio-based molecules. These molecules are then used as secondary raw materials to produce bio-based pigments for textiles. The project aims to optimize this process and test it on a larger scale with the assistance of HAN BioCentre. This initiative aligns with Dutch government and EU regulations mandating textile recycling by 2050. The technology used is patent pending and does not involve the use of toxic chemicals or the release of harmful wastewater or fumes, contributing to a shift towards a more circular and sustainable textile industry by reintegrating natural colorants into textile production.
Paper sludge contains papermaking mineral additives and fibers, which could be reused or recycled, thus enhancing the circularity. One of the promising technologies is the fast pyrolysis of paper sludge, which is capable of recovering > 99 wt.% of the fine minerals in the paper sludge and also affording a bio-liquid. The fine minerals (e.g., ‘circular’ CaCO3) can be reused as filler in consumer products thereby reducing the required primary resources. However, the bio-liquid has a lower quality compared to fossil fuels, and only a limited application, e.g., for heat generation, has been applied. This could be significantly improved by catalytic upgrading of the fast pyrolysis vapor, known as an ex-situ catalytic pyrolysis approach. We have recently found that a high-quality bio-oil (mainly ‘bio-based’ paraffins and low-molecular-weight aromatics, carbon yield of 21%, and HHV of 41.1 MJ kg-1) was produced (Chem. Eng. J., 420 (2021), 129714). Nevertheless, catalyst deactivation occurred after a few hours’ of reaction. As such, catalyst stability and regenerability are of research interest and also of high relevance for industrial implementation. This project aims to study the potential of the add-on catalytic upgrading step to the industrial fast pyrolysis of paper sludge process. One important performance metric for sustainable catalysis in the industry is the level of catalyst consumption (kgcat tprod-1) for catalytic pyrolysis of paper sludge. Another important research topic is to establish the correlation between yield and selectivity of the bio-chemicals and the catalyst characteristics. For this, different types of catalysts (e.g., FCC-type E-Cat) will be tested and several reaction-regeneration cycles will be performed. These studies will determine under which conditions catalytic fast pyrolysis of paper sludge is technically and economically viable.
