Background and purpose: Automatic approaches are widely implemented to automate dose optimization in radiotherapy treatment planning. This study systematically investigates how to configure automatic planning in order to create the best possible plans. Materials and methods: Automatic plans were generated using protocol based automatic iterative optimization. Starting from a simple automation protocol which consisted of the constraints for targets and organs at risk (OAR), the performance of the automatic approach was evaluated in terms of target coverage, OAR sparing, conformity, beam complexity, and plan quality. More complex protocols were systematically explored to improve the quality of the automatic plans. The protocols could be improved by adding a dose goal on the outer 2 mm of the PTV, by setting goals on strategically chosen subparts of OARs, by adding goals for conformity, and by limiting the leaf motion. For prostate plans, development of an automated post-optimization procedure was required to achieve precise control over the dose distribution. Automatic and manually optimized plans were compared for 20 head and neck (H&N), 20 prostate, and 20 rectum cancer patients. Results: Based on simple automation protocols, the automatic optimizer was not always able to generate adequate treatment plans. For the improved final configurations for the three sites, the dose was lower in automatic plans compared to the manual plans in 12 out of 13 considered OARs. In blind tests, the automatic plans were preferred in 80% of cases. Conclusions: With adequate, advanced, protocols the automatic planning approach is able to create high-quality treatment plans.
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Out-of-plane (OOP) wall collapse is one of the most common failure mechanismsin unreinforced masonry (URM) structures. Insufficient connections at wall-to-wall, wall-to-floor or wall-to-roof levels are one of the main reasons for OOP failures. The seismic assessment of URM buildings with insufficient connections became of high relevance. In particular, cavity walls are widely used in many regions, such as Central and Northern Europe, Australia, New Zealand, China, and Groningen in the Netherlands. Defining thus the behaviour of such connections is of prime importance to understand the overall response of URM buildings.This paper is about an experimental campaign conducted at the BuildinG laboratory of Hanze University of Applied Sciences on timber joist-masonry connections, reproducing cavity walls with timber joists in as-built condition. A total of six URM tests were performed, with varying configurations as: two different tie distributions, two precompression levels and two different as-built connections. The tests aim at providing a complete characterization of the behaviour of the timber-joist cavity-wall connections under axial cyclic loading with special attention on the developed failure mechanism and the definition of force-displacement curves for each group of tests performed. The experimental results show that cohesion and friction between joist and masonry are important parameters in terms of the governing failure mechanism, whether it is a joist-sliding or rocking failure.
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This article compares two similar yet never compared cases of intra-European othering: Spain and the South Slavic region. Their common denominator is what I call the Periphery Problem: a hierarchical cultural difference between Europe’s symbolic centre (Western Europe) and its exotic peripheries. Using paradigmatic examples intertextually linked to Prosper Mérimée, this article focuses both on the centre (exemplified by Mérimée), and the peripheries’ recent responses to Mérimée through meta-images (your image of others’ image of you). The structural commonalities in characterization and the entanglements of internal and external images show that national characterization in Europe is profoundly a transnational phenomenon.
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Spectral imaging has many applications, from methane detection using satellites to disease detection on crops. However, spectral cameras remain a costly solution ranging from 10 thousand to 100 thousand euros for the hardware alone. Here, we present a low-cost multispectral camera (LC-MSC) with 64 LEDs in eight different colors and a monochrome camera with a hardware cost of 340 euros. Our prototype reproduces spectra accurately when compared to a reference spectrometer to within the spectral width of the LEDs used and the ±1σ variation over the surface of ceramic reference tiles. The mean absolute difference in reflectance is an overestimate of 0.03 for the LC-MSC as compared to a spectrometer, due to the spectral shape of the tiles. In environmental light levels of 0.5 W m−2 (bright artificial indoor lighting) our approach shows an increase in noise, but still faithfully reproduces discrete reflectance spectra over 400 nm–1000 nm. Our approach is limited in its application by LED bandwidth and availability of specific LED wavelengths. However, unlike with conventional spectral cameras, the pixel pitch of the camera itself is not limited, providing higher image resolution than typical high-end multi- and hyperspectral cameras. For sample conditions where LED illumination bands provide suitable spectral information, our LC-MSC is an interesting low-cost alternative approach to spectral imaging.
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In recent years, the number of human-induced earthquakes in Groningen, a large gas field in the north of the Netherlands, has increased. The majority of the buildings are built by using unreinforced masonry (URM), most of which consists of cavity (i.e. two-leaf) walls, and were not designed to withstand earthquakes. Efforts to define, test and standardize the metal ties, which do play an important role, are valuable also from the wider construction industry point of view. The presented study exhibits findings on the behavior of the metal tie connections between the masonry leaves often used in Dutch construction practice, but also elsewhere around the world. An experimental campaign has been carried out at Delft University of Technology to provide a complete characterization of the axial behavior of traditional connections in cavity walls. A large number of variations was considered in this research: two embedment lengths, four pre-compression levels, two different tie geometries, and five different testing protocols, including monotonic and cyclic loading. The experimental results showed that the capacity of the connection was strongly influenced by the embedment length and the geometry of the tie, whereas the applied pre-compression and the loading rate did not have a significant influence.
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An important step towards improving performance while reducing weight and maintenance needs is the integration of composite materials into mechanical and aerospace engineering. This subject explores the many aspects of composite application, from basic material characterization to state-of-the-art advances in manufacturing and design processes. The major goal is to present the most recent developments in composite science and technology while highlighting their critical significance in the industrial sector—most notably in the wind energy, automotive, aerospace, and marine domains. The foundation of this investigation is material characterization, which offers insights into the mechanical, chemical, and physical characteristics that determine composite performance. The papers in this collection discuss the difficulties of gaining an in-depth understanding of composites, which is necessary to maximize their overall performance and design. The collection of articles within this topic addresses the challenges of achieving a profound understanding of composites, which is essential for optimizing design and overall functionality. This includes the application of complicated material modeling together with cutting-edge simulation tools that integrate multiscale methods and multiphysics, the creation of novel characterization techniques, and the integration of nanotechnology and additive manufacturing. This topic offers a detailed overview of the current state and future directions of composite research, covering experimental studies, theoretical evaluations, and numerical simulations. This subject provides a platform for interdisciplinary cooperation and creativity in everything from the processing and testing of innovative composite structures to the inspection and repair procedures. In order to support the development of more effective, durable, and sustainable materials for the mechanical and aerospace engineering industries, we seek to promote a greater understanding of composites.
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Apart from tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), a third PA appears to occur in human plasma. Its activity is initiated when appropriate triggers of the contact system are added, and the activation depends on the presence of factor XII and prekallikrein in plasma. The activity of this, so-called, contact-system dependent PA accounts for 30% of the PA activity in the dextran sulphate euglobulin fraction of plasma and was shown not to be an intrinsic property of one of the contact-system components, nor could it be inhibited by inhibitory antibodies against t-PA or u-PA. We have succeeded in identifying this third PA in dextran sulphate euglobulin fractions of human plasma. Its smallest unit (SDS-PAGE) is an inactive 110 kDa single-chain polypeptide which upon activation of the contact system is converted to a cleaved, disulphide-bridged molecule with PA activity. The native form, presumably, is an oligomer, since the apparent Mr on gel-chromatography is 600,000. The IEP is 4.8, much lower than that of t-PA and u-PA. Although the active 110 kDa polypeptide cannot be inhibited by anti-u-PA, it yet comprises a 37 kDa piece with some u-PA related antigenic determinants. However, these determinants are in a latent or cryptic form, only detectable after denaturation by SDS. The 110 kDa polypeptide is evidently not a dimer of 55 kDa u-PA or a complex of u-PA with an inhibitor.(ABSTRACT TRUNCATED AT 250 WORDS)
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The installation of facilities replicating the realworld condition is often required for carrying out meaningful tests on new devices and for collecting data with the aim to create realistic device model. However, these facilities require huge investments, as well as areas where they can be properly installed. In this paper, we present a test infrastructure exploiting the concept of Remote Power Hardware-In-the-Loop (RPHIL), applied for characterizing the performances of a 8kW Proton Exchange Membrane (PEM) electrolyser installed at the Hanze University of Applied Sciences in Groningen (The Netherlands). The electrolyser is subjected to different test conditions imposed both locally and remotely. The results show that this measurement procedure is effective and can open new perspectives in the way to share and exploit the existing research infrastructure in Europe
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This paper describes the results of a second year Expo project team of Fontys Engineering, department Mechanical Engineering. During this research the design of a configurable damped spring design has been investigated. A calculation tool has been defined and validated using a Nylon 3D printed spring prototype. Also a theoretical design of a stainless steel spring has been made including stress calculations. Finally characterization tests on damping properties have been performed.
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We have developed an SI-traceable narrow-band tunable radiance source based on an optical parametric oscillator (OPO) and an integrating sphere for the calibration of spectroradiometers. The source is calibrated with a reference detector over the ultraviolet/visible spectral range with an uncertainty of <1%. As a case study, a CubeSat spectroradiometer has been calibrated for radiance over its operating range from 370 nm to 480 nm. To validate the results, the instrument has also been calibrated with a traditional setup based on a diffuser and an FEL lamp. Both routes show good agreement within the combined measurement uncertainty. The OPO-based approach could be an interesting alternative to the traditional method, not only because of reduced measurement uncertainty, but also because it directly allows for wavelength calibration and characterization of the instrumental spectral response function and stray light effects, which could reduce calibration time and cost.
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