Lectorale rede van Dave van Kann gehouden ter gelegenheid van zijn inauguratie als lector ‘Leren Bewegen in en rondom de School’ bij Lectoraat Move to Be van Fontys Sporthogeschool. Dave geeft in zijn rede aan op welke directe thematische focus hij zich in het bijzonder zal gaan richten in zijn lectorschap (de themalijnen Leren Bewegen en Beweegvriendelijke Omgeving). In lijn met de lectoraatsprojecten en -ambities geeft Dave zijn zienswijze op de thematiek ‘Leren Bewegen in en rondom de School’ weer en houd hij een pleidooi om in gezamenlijkheid met alle betrokkenen de komende jaren te werken aan een actieve generatie waarin bewegen meer vanzelfsprekend is en voor iedereen mogelijk.
We live in an increasingly complex world, characterised by interconnected and intractable wicked problems. Systems mapping offers a visual approach for collectively understanding and envisioning how to coordinate the addressing of these problems. The agri-food sector is facing severe problems and systems mapping could be particularly instrumental in helping it navigate these difficulties.
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Over the last years a large growth in Electric Vehicles (EV) and charging infrastructure (CI) development has been observed. Particularly in metropolitan areas this growth has led to a system in which multitudes of interactions between EV users take place. While many researchers have focused on EV user charging behavior and deployment strategies for CI, little attention has been paid to conceptualizing the problem domain. This research provides a brief overview of complex systems theory, and derives six characterizing elements of complex systems that may be applicable for CI. The paper investigates both theoretically but also empirically how these characterizing elements apply for CI and provides implications for the further roll-out of CI for both policy makers and researchers. We illustrate our findings with preliminary results form ongoing research. Recommendations include the further development of simulation tools that are capable of exploring effects of e.g. non-linear behavior, feedback loops and emergence of new patterns on CI performance. In the end this paper aims to provide directions to enable policy makers to be better prepared for the anticipated exponential growth of EVs and CI.
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CRISPR/Cas genome engineering unleashed a scientific revolution, but entails socio-ethical dilemmas as genetic changes might affect evolution and objections exist against genetically modified organisms. CRISPR-mediated epigenetic editing offers an alternative to reprogram gene functioning long-term, without changing the genetic sequence. Although preclinical studies indicate effective gene expression modulation, long-term effects are unpredictable. This limited understanding of epigenetics and transcription dynamics hampers straightforward applications and prevents full exploitation of epigenetic editing in biotechnological and health/medical applications.Epi-Guide-Edit will analyse existing and newly-generated screening data to predict long-term responsiveness to epigenetic editing (cancer cells, plant protoplasts). Robust rules to achieve long-term epigenetic reprogramming will be distilled based on i) responsiveness to various epigenetic effector domains targeting selected genes, ii) (epi)genetic/chromatin composition before/after editing, and iii) transcription dynamics. Sustained reprogramming will be examined in complex systems (2/3D fibroblast/immune/cancer co-cultures; tomato plants), providing insights for improving tumor/immune responses, skin care or crop breeding. The iterative optimisations of Epi-Guide-Edit rules to non-genetically reprogram eventually any gene of interest will enable exploitation of gene regulation in diverse biological models addressing major societal challenges.The optimally balanced consortium of (applied) universities, ethical and industrial experts facilitates timely socioeconomic impact. Specifically, the developed knowledge/tools will be shared with a wide-spectrum of students/teachers ensuring training of next-generation professionals. Epi-Guide-Edit will thus result in widely applicable effective epigenetic editing tools, whilst training next-generation scientists, and guiding public acceptance.
