Rationale: Diagnosis of sarcopenia in older adults is essential for early treatment in clinical practice. Bio-electrical impedance analysis (BIA) may be a valid means to assess appendicular lean mass (ALM) in older adults, but limited evidence is available. Therefore, we aim to evaluate the validity of BIA to assess ALM in older adults.Methods: In 215 community dwelling older adults (age ≥ 55 years), ALM was measured by BIA (Tanita MC-780; 8-points) and compared with dual-energy X-ray absorptiometry (DXA, Hologic Discovery A) as reference. Validity for assessing absolute values of ALM was evaluated by: 1) bias (mean difference), 2) percentage of accurate predictions (within 5% of DXA values), 3) individual error (root mean squared error (RMSE), mean absolute deviation), 4) limits of agreement (Bland-Altman analysis). For diagnosis of low ALM, the lowest quintile of ALM by DXA was used (below 21.4 kg for males and 15.4 for females). Sensitivity and specificity of detecting low ALM by BIA were assessed.Results: Mean age of the subjects was 71.9 ± 6.4, with a BMI of 25.8 ± 4.2 kg/m2, and 70% were females. BIA slightly underestimated ALM compared to DXA with a mean bias of -0.6 ± 0.2 kg. The percentage accurate predictions was 54% with RMSE 1.6 kg and limits of agreements −3.0 to +1.8 kg. Sensitivity was 79%, indicating that 79% of subjects with low ALM according to DXA also had low ALM with the BIA. Specificity was 90%, indicating that 90% of subjects with ‘no low’ ALM according to DXA also had ‘no low’ ALM with the BIA.Conclusions: This comparison showed a poor validity of BIA to assess absolute values of ALM, but a reasonable sensitivity and specificity to diagnose a low level of ALM in community-dwelling older adults in clinical practice.Disclosure of interest: None declared.
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In this article a generic fault detection and diagnosis (FDD) method for demand controlled ventilation (DCV) systems is presented. By automated fault detection both indoor air quality (IAQ) and energy performance are strongly increased. This method is derived from a reference architecture based on a network with 3 generic types of faults (component, control and model faults) and 4 generic types of symptoms (balance, energy performance, operational state and additional symptoms). This 4S3F architecture, originally set up for energy performance diagnosis of thermal energy plants is applied on the control of IAQ by variable air volume (VAV) systems. The proposed method, using diagnosis Bayesian networks (DBNs), overcomes problems encountered in current FDD methods for VAV systems, problems which inhibits in practice their wide application. Unambiguous fault diagnosis stays difficult, most methods are very system specific, and finally, methods are implemented at a very late stage, while an implementation during the design of the HVAC system and its control is needed. The IAQ 4S3F method, which solves these problems, is demonstrated for a common VAV system with demand controlled ventilation in an office with the use of a whole year hourly historic Building Management System (BMS) data and showed it applicability successfully. Next to this, the influence of prior and conditional probabilities on the diagnosis is studied. Link to the formal publication via its DOI https://doi.org/10.1016/j.buildenv.2019.106632
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Purpose – The purpose of this paper is to examine the prevalence of psychopathology including substance use disorders in a sample of detained female systematic offenders.Design/methodology/approach – All case files of female systematic offenders who had been subjected to a special court order for systematic offenders in the period 2004-2014 were studied. A total of 81 fairly complete case files were selected for the study. These were all systematic offenders as they had been sentenced for at least 25 offences with an average of 102 offences over a period of 17.5 years. Findings – All except one woman were addicted to substances in the past year, with an average duration of addiction of 21 years. In addition, 53 per cent were diagnosed with another DSM Axis I disorder and 73 per cent were diagnosed with a personality disorder. Furthermore, 32-59 per cent were found to haveintellectual dysfunctions. In total, 12 per cent had one type of the above disorders, 43 per cent two types, 31 per cent three types and 14 per cent all four types. The prevalence rates of these disorders were higher than those reported in other prison studies.Research limitations/implications – It is concluded that female systematic offenders can be characterised as problematic in many respects. Even in such a problematic group treatment can be provided.Originality/value – The present study is the only study that provides prevalence data of mental disorders among female systematic offenders.
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