This comprehensive document shares up-to-date knowledge on Early Warning Signals of business crisis, presents detection and intervention opportunities, and makes a clear case for their beneficial application to SME leadership and overall business resilience.
MULTIFILE
Introduction Around 25% of metastatic breast cancer (mBC) patients develop brain metastases, which vastly affects their overall survival and quality of life. According to the current clinical guidelines, regular magnetic resonance imaging screening is not recommended unless patients have recognized central nervous system-related symptoms. Patient Presentation The patient participated in the EFFECT study, a randomized controlled trial aimed to assess the effects of a 9-month structured, individualized and supervised exercise intervention on quality of life, fatigue and other cancer and treatment-related side effects in patients with mBC. She attended the training sessions regularly and was supervised by the same trainer throughout the exercise program. In month 7 of participation, her exercise trainer detected subtle symptoms (e.g., changes in movement pattern, eye movement or balance), which had not been noticed or reported by the patient herself or her family, and which were unlikely to have been detected by the oncologist or other health care providers at that point since symptoms were exercise related. When suspicion of brain metastases was brought to the attention of the oncologist by the exercise trainer, the response was immediate, and led to early detection and treatment of brain metastases. Conclusion and clinical implications The brain metastases of this patient were detected earlier due to the recognition of subtle symptoms detected by her exercise trainer and the trust and rapid action by the clinician. The implementation of physical exercise programs for cancer patients requires well-trained professionals who know how to recognize possible alterations in patients and also, good communication between trainers and the medical team to enable the necessary actions to be taken.
Bespreking academisch proefschrift N. Boonstra (RU Groningen). Dit proefschrift heeft als centraal thema de vroegtijdige onderkenning van de eerste psychotische symptomen bij psychiatrische patiënten. Een centrale behandeldoelstelling hierbij is om de duur van de onbehandelde psychose (Duration of Untreated Psychosis, afgekort DUP) zo kort mogelijk te Iaten zljn. De DUP verwljst naar de tijd die verstrljkt tussen de eerste manifestatie van psychotische symptomen en het moment waarop een hlerblj passende behandeling start. Een kortere DUP blijkt samen te hangen met een betere prognose van de ziekte, zich ultend in een vroegere en betere remissie, minder psychotische terugval, minder cognitleve achteruitgang, minder psychotische symptomen en beter sociaal functioneren.
Agricultural/horticultural products account for 9% of Dutch gross domestic product. Yearly expansion of production involves major challenges concerning labour costs and plant health control. For growers, one of the most urgent problems is pest detection, as pests cause up to 10% harvest loss, while the use of chemicals is increasingly prohibited. For consumers, food safety is increasingly important. A potential solution for both challenges is frequent and automated pest monitoring. Although technological developments such as propeller-based drones and robotic arms are in full swing, these are not suitable for vertical horticulture (e.g. tomatoes, cucumbers). A better solution for less labour intensive pest detection in vertical crop horticulture, is a bio-inspired FW-MAV: Flapping Wings Micro Aerial Vehicle. Within this project we will develop tiny FW-MAVs inspired by insect agility, with high manoeuvrability for close plant inspection, even through leaves without damage. This project focusses on technical design, testing and prototyping of FW-MAV and on autonomous flight through vertically growing crops in greenhouses. The three biggest technical challenges for FW-MAV development are: 1) size, lower flight speed and hovering; 2) Flight time; and 3) Energy efficiency. The greenhouse environment and pest detection functionality pose additional challenges such as autonomous flight, high manoeuvrability, vertical take-off/landing, payload of sensors and other equipment. All of this is a multidisciplinary challenge requiring cross-domain collaboration between several partners, such as growers, biologists, entomologists and engineers with expertise in robotics, mechanics, aerodynamics, electronics, etc. In this project a co-creation based collaboration is established with all stakeholders involved, integrating technical and biological aspects.
This proposal envisions a solution for organizations and their employees to keep each other resilient and healthy.We aim for proactive detection of stress at an early stage, so it can facilitate a safe and collaborative dialogue between employers and employees at a time that they are both still able to see their co-dependency and mutual interests, while acknowledging the possible tension of conflicting interests. A sorrow shared is a sorrow halved.We use an Impact Plan Approach in which a Theory of Change (the DESTRESS Strategy) directs research activities that identify problems and causse, determine the required change to overcome them, and adjust the DESTRESS strategy to make improvements that are necessary to invoke that change. Subsequently, the DESTRESS strategy will be translated into the DESTRESS solution, for which a strategy for implementation and evaluation will be devised.
Pre-eclampsia (PE) is a common and severe pregnancy complication and is associated with substantial perinatal morbidity and mortality in mothers and infants. The disease is often characterized by a non-specific presentation which makes it challenging for physician to diagnose PE during regular pregnancy check-ups. To date, there are no diagnostic tests on the market for detection of PE early in pregnancy (first trimester). In this project, we will develop a platform to sensitively analyse calcium-binding proteins (CBPs) which will unlock the full potential of CBPs as predictive PE markers. The technology will also be applicable for other diseases (e.g., dementia and cancer) where CBPs are also known to play a key role in disease pathophysiology. We will develop with phage display antibodies that can recognize calcium binding to specific motifs in proteins. To this end we will synthesize peptide motifs with and without calcium to select antibodies that are specific for calcium bound proteins. These antibodies will be validated for their clinical use. For this goal we will use serum samples from the Improved studie (EU subsidised study) to determine if we can recognize pre-eclampsia in a very early stage. This knowledge can lead to a better treatment of pregnant women suffering from this disease and also will probably increase the well-being for the baby born and the development further in life.
