Abstract Chapter 4: Basing ourselves on a literature review and expert interviews we create an overview of methods and tools to identify and respond to ethical questions used in healthcare, social work, police and the military. We identify six main types of methods or tools that can support professionals or organisations in dealing with ethical issues. Some of these methods are already used in CT or could be used. Some methods or tools are targeted at individual professionals or small groups, whilst others are targeted at the organisational level. The methods and tools are described in brief. Samenvatting boek: Wat is ethisch wel en wat niet geoorloofd? De aanslagen die de Europese hoofdsteden teisteren wrijven het ons in: terrorismebestrijding is noodzakelijk en is onlosmakelijk verbonden met de moderne samenleving. De inlichtingendiensten en andere organisaties die zich hiermee bezighouden, stuiten echter telkens op de vraag hoe ver zij mogen gaan. Waar liggen de grenzen? Wat is ethisch wel en wat niet geoorloofd? En vooral: hoe gaan professionals met deze soms levensgrote dilemma's om? In deze Engelstalige uitgave reflecteren wetenschappers, terrorismebestrijders en ethici op dit zeer actuele thema.
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Global food systems need to become more sustainable, resilient and inclusive. To accelerate this transition, there is a need for scaling innovative strategies for improved Food and Nutrition Security (FNS), particularly for the poor and marginalised. Scaling, however, is not a straightforward or value-free process. The synthesis study examined which dilemmas influence Research for Impact projects that seek to contribute to FNS outcomes at scale, and how blind spots in scaling research and practice are tied to these dilemmas. Being aware of and tackling these blind spots at an early stage contributes to ‘responsible scaling’: not only focusing on technical and socio-economic, but also on ethical considerations about who will benefit or lose out. The findings presented in the full paper are based on insights from ten interdisciplinary research projects funded by NWO-WOTRO that were carried out in countries in East, Southern and the Horn of Africa between 2014–2020.
Abstract for World Physiotherapy Congress 2021Title Ethical Considerations of Using Machine Learning for Decision Support in Occupational Physical Therapy: a narrative literature study and ethical deliberation. Authors Marianne W. M. C. Six Dijkstra1,4,7 · Egbert Siebrand2 · Steven Dorrestijn2 · Etto L. Salomons3 ·Michiel F. Reneman4 · Frits G. J. Oosterveld1 · Remko Soer1,5 · Douglas P. Gross6 · Hendrik J. Bieleman1 Presenter and contactName: Marianne W. M. C. Six DijkstraEmail: w.m.c.sixdijkstra@saxion.nlAdres: School of Health, Saxion University of Applied Sciences/AGZ, M.H. Tromplaan 28, 7500 KB, Enschede, The NetherlandsTel: +31(0)612379329 1 School of Health, Saxion University of AppliedSciences, Enschede, The Netherlands2 Research Group Ethics & Technology, Saxion Universityof Applied Sciences, Enschede, The Netherlands3 School of Ambient Intelligence, Saxion Universityof Applied Sciences, Enschede, The Netherlands4 Department of Rehabilitation Medicine, University MedicalCenter Groningen, University of Groningen, Groningen,The Netherlands5 University Medical Center Groningen, Pain Centre,University of Groningen, Groningen, The Netherlands6 Department of Physical Therapy, University of Alberta,Edmonton, Canada7 University of Groningen, Groningen, The Netherlands Funding This study was funded by Netherlands Organisation for Scientific Research (NWO) (023.011.076) and Saxion University of Applied Sciences in The Netherlands. The funding source had no involvementin study design, data collection, analysis or interpretation, in the writing of the report, or the decision to submit the article for publication.Ethical approvalThis study is part of a PhD project entitled “Development of a Decision Support System – Artificial Intelligence advices for Sustainable Employability”. The Ethics Board at the University Medical Center Groningen in The Netherlands decided that formal approval of the study was not necessary because all workers were subjected to care as usual only.AbstractBackground Computer algorithms and Machine Learning (ML) will be integrated into clinical decision support within physical therapy. This will change the interaction between therapists and their clients, with unknown consequences.Purpose The aim of this study was to explore ethical considerations and potential consequences of using ML based decision support tools (DSTs). We used an example in the context of occupational physical therapy.Methods We conducted an ethical deliberation. This was supported by a narrative literature review of publications about ML and DSTs in occupational health and by an assessment of the potential impact of ML-DSTs according to frameworks from medical ethics and philosophy of technology. We introduce a hypothetical clinical scenario in occupational physical therapy to reflect on biomedical ethical principles: respect for autonomy, beneficence, non-maleficence and justice. The reflection was guided by the Product Impact Tool.
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CRISPR/Cas genome engineering unleashed a scientific revolution, but entails socio-ethical dilemmas as genetic changes might affect evolution and objections exist against genetically modified organisms. CRISPR-mediated epigenetic editing offers an alternative to reprogram gene functioning long-term, without changing the genetic sequence. Although preclinical studies indicate effective gene expression modulation, long-term effects are unpredictable. This limited understanding of epigenetics and transcription dynamics hampers straightforward applications and prevents full exploitation of epigenetic editing in biotechnological and health/medical applications.Epi-Guide-Edit will analyse existing and newly-generated screening data to predict long-term responsiveness to epigenetic editing (cancer cells, plant protoplasts). Robust rules to achieve long-term epigenetic reprogramming will be distilled based on i) responsiveness to various epigenetic effector domains targeting selected genes, ii) (epi)genetic/chromatin composition before/after editing, and iii) transcription dynamics. Sustained reprogramming will be examined in complex systems (2/3D fibroblast/immune/cancer co-cultures; tomato plants), providing insights for improving tumor/immune responses, skin care or crop breeding. The iterative optimisations of Epi-Guide-Edit rules to non-genetically reprogram eventually any gene of interest will enable exploitation of gene regulation in diverse biological models addressing major societal challenges.The optimally balanced consortium of (applied) universities, ethical and industrial experts facilitates timely socioeconomic impact. Specifically, the developed knowledge/tools will be shared with a wide-spectrum of students/teachers ensuring training of next-generation professionals. Epi-Guide-Edit will thus result in widely applicable effective epigenetic editing tools, whilst training next-generation scientists, and guiding public acceptance.
With the help of sensors that made data collection and processing possible, many products around us have become “smarter”. The situation that our car, refrigerator, or umbrella communicating with us and each other is no longer a future scenario; it is increasingly a shared reality. There are good examples of such connectedness such as lifestyle monitoring of elderly persons or waste management in a smart city. Yet, many other smart products are designed just for the sake of embedding a chip in something without thinking through what kind of value they add everyday life. In other words, the design of these systems have mainly been driven by technology until now and little studies have been carried out on how the design of such systems helps citizens to improve or maintain the quality of their individual and collective lives. The CREATE-IT research center creates new solutions and methodologies in “digital design” that contribute to the quality of life of citizens. Correspondingly, this proposal focuses on one type of digital design—smart products—and investigate the concept of empowerment in relation to the design of smart products. In particular, the proposal aims to develop a model with its supplementary tools and methods for designing such products better. By following a research-through-design methodology, the proposal intends to offer a critical understanding on designing smart products. Along with its theoretical contribution, the proposal will also aid the students of ICT and design, and professionals such as designers and engineers to create smart products that will empower people and the industry to develop products grounded in a clear user experience and business model.
