Using stable isotope techniques, this study shows that plasma free fatty acid oxidation is not impaired during exercise in non-obese type II diabetic patients.
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The catalytic conversion of oleic acid to aromatics (benzene, toluene, and xylenes, BTX) over a granular H-ZSM-5/Al2O3 catalyst (ϕ 1.2–1.8 mm, 10 g loading) was investigated in a continuous bench-scale fixed-bed reactor (10 g oleic acid h–1). A peak carbon yield of aromatics of 27.4% was obtained at a catalyst bed temperature of 550 °C and atmospheric pressure. BTX was the major aromatics formed (peak carbon yield was 22.7%), and a total BTX production of 1000 mg g–1 catalyst was achieved within a catalyst lifetime of 6.5 h for the fresh catalyst. The catalyst was deactivated due to severe coke deposition (ca. 22.1 wt % on the catalyst). The used catalyst was reactivated by an ex situ oxidative regeneration at 680 °C in air for 12 h. The regenerated catalyst was subsequently recycled, and in total, 7 cycles of reaction-regeneration were performed. A gradual decrease in the peak carbon yield of BTX was observed with reaction-regeneration cycles (e.g., to 16.3% for the catalyst regenerated for 6 times). However, the catalyst lifetime was remarkably prolonged (e.g., >24 h), leading to a significantly enhanced total BTX production (e.g., 3000 mg g–1 catalyst in 24 h). The fresh, used, and regenerated catalysts were characterized by N2 and Ar physisorption, XRD, HR-TEM-EDX, 27Al, and 29Si MAS ssNMR, NH3-TPD, TGA, and CHN elemental analysis. Negligible changes in textural properties, crystalline structure, and framework occurred after one reaction-regeneration cycle, except for a slight decrease in acidity. However, dealumination of the H-ZSM-5 framework was observed after 7 cycles of reaction-regeneration, leading to a decrease in microporosity, crystallinity, and acidity. Apparently, these changes are not detrimental for catalyst activity, and actually, the lifetime of the catalyst increases, rationalized by considering that coke formation rates are retarded when the acidity is reduced.
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The Andean lupin (Lupinus mutabilis) is one of the lost crops of Incas and has been grown in South America and as a food crop for thousands of years. The seeds are the main source of commercial value regarding the high content of oil (about 20%), protein (about 43%) and carbohydrates (about 33%). A European Union H2020 project, LIBBIO, aims to develop and optimize the breeding and cropping of the Andean lupin in the Europe, and to process the lupin seeds for new and high-value products for consumers and for incorporation into otherproducts. This study works at optimizing the oil extraction from the lupin seeds using supercritical carbon dioxide (scCO2), which has been tested for lupin oil extraction and is advantageous over organic extractants due to the mild operating temperature, costeffectiveness, nontoxicity, and easy post-separation.In the study designed by response surface methodology, the operating pressure,temperature, scCO2 flowrate, and sample mesh size, were investigated on their effect on the oil extraction efficiency. The pressure, scCO2 flowrate and mesh size were found to affect the extraction efficiency significantly. The higher the pressure and the smaller the mesh, the more oil was extracted over a specific period. Optimally about 85% of the oil was extracted by scCO2 compared with conventional Soxhlet extraction using hexane as the extractant. Oleicacid (46%) and Linoleic acid (32%) are the two main fatty acids in the extracted oil. About 80% of the fatty acids are unsaturated. The stearic acid is one of the main saturated fatty acids, which has relatively positive effects on human health to others. The pressure was found to significantly affect the fractions of the saturated and unsaturated fatty acids. The content of tocopherols in the extracted oil ranged from 1 to 20 mg/100g oil, which is comparable withliterature value.
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Glycerol is an attractive bio-based platform chemical that can be converted to a variety of bio-based chemicals. We here report a catalytic co-conversion strategy where glycerol in combination with a second (bio-)feed (fatty acids, alcohols, alkanes) is used for the production of bio-based aromatics (BTX). Experiments were performed in a fixed bed reactor (10 g catalyst loading and WHSV of (co-)feed of 1 h-1) at 550 °C using a technical H-ZSM-5/Al2O3 catalyst. Synergistic effects of the co-feeding on the peak BTX carbon yield, product selectivity, total BTX productivity, catalyst life-time, and catalyst regenerability were observed and quantified. Best results were obtained for the co-conversion of glycerol and oleic acid (45/55 wt%), showing a peak BTX carbon yield of 26.7 C%. The distribution of C and H of the individual co-feeds in the BTX product was investigated using an integrated fast pyrolysis-GC-Orbitrap MS unit, showing that the aromatics are formed from both glycerol and the co-feed. The results of this study may be used to develop optimized co-feeding strategies for BTX formation. This journal is
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Seaweeds from the genus Porphyra play a big economic role in seaweed aquaculture, mainly in Asia. In Europe, resources are put towards seaweed cultivation, but without attention to the Porphyra species which is also native to Europe. Different nomenclature and specifications are used to describe Porphyra, due to taxonomical reclassification and difficult phenotypical identification. Abiotic & biotic together with seasonal factors make for major variance in chemical compositions that are reported. This is also fueled by differences in chemical analytical methods and procedures followed. Combining taxonomical challenges, variance due to seasonal factors and differences in analysis, overviewing published research on Porphyra constituents such as protein, polysaccharides and fatty acids is warranted. Within this review, cellular consitutents found in Porphyra are discussed, including proteins, polysaccharides, fatty acids and mycosporine-like amino acids (MAA’s). MAA's are considered amongst the strongest UV-photoprotectants found in nature and feature possible applications in cosmetics. As global interest in seaweeds as food, feed and industrial resource is emerging, opportunities for Porphyra constituents is rising.
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Dark homogenous fungal-based layers called biofinishes and vegetable oils are keyingredients of an innovative wood protecting system. The aim of this study was todetermine which of the vegetable oils that have been used to generate biofinishes onwood will provide carbon and energy for the biofinish-inhabiting fungus Aureobasidiummelanogenum, and to determine the effect of the oil type and the amount of oil on thecell yield. Aureobasidium melanogenum was cultivated in shake flasks with differenttypes and amounts of carbon-based nutrients. Oil-related total cell and colony-formingunit growth were demonstrated in suspensions with initially 1% raw linseed,stand linseed, and olive oil. Oil-related cell growth was also demonstrated with rawlinseed oil, using an initial amount of 0.02% and an oil addition during cultivation. Nilered staining showed the accumulation of fatty acids inside cells grown in the presenceof oil. In conclusion, each tested vegetable oil was used as carbon and energysource by A. melanogenum. The results indicated that stand linseed oil provides lesscarbon and energy than olive and raw linseed oil. This research is a fundamental stepin unraveling the effects of vegetable oils on biofinish formation.
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The results of this study indicate that whole body metabolic and cardiovascular responses to 140 min of either steady state or variable intensity exercise at the same average intensity are similar, despite differences in skeletal muscle carbohydrate metabolism and recruitment
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https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.6b00298 From teh publisher: "Several studies indicate that the n-3 long-chain polyunsaturated fatty acid docosahexaenoic acid (DHA) contributes to an attenuated inflammatory status in the development of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. To explain these effects, different mechanisms are being proposed, including those involving endocannabinoids and related signaling molecules. Many of these compounds belong to the fatty acid amides, conjugates of fatty acids with biogenic amines. Conjugates of DHA with ethanolamine or serotonin have previously been shown to possess anti-inflammatory and potentially neuroprotective properties. Here, we synthesized another amine conjugate of DHA, N-docosahexaenoyl dopamine (DHDA), and tested its immune-modulatory properties in both RAW 264.7 macrophages and BV-2 microglial cells."
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Dit artikel is een op uitnodiging van het tijdschrift Acta Physiologica geschreven "Editorial" over het proeven van vetzuren door zoogdieren. Het artikel refereert naar een studie van Nagai et al. dat in juli 2025 in Acta Physiologica verscheen onder de titel “Fatty Acid Taste Quality Information via GPR40 and CD36 in the Posterior Tongue of Mice”. Daarin worden experimenten beschreven die erop duiden dat het proeven van vetzuren door dezelfde zenuwen van de muizentong wordt doorgegeven als het proeven van zoet en/of umami. Muizen ervaren de smaak van vetzuren volgens Nagai et al. als smakelijk, terwijl van mensen bekend is dat zij de smaak van vetzuren, ook wel bekend onder de naam "oleogustus", als onsmakelijk ervaren. De vraag is of mensen en muizen zo erg verschillen of dat het misschien een dosis-effect van de geteste hoeveelheden vetzuren kan zijn waarmee dit verschil verklaard kan worden.
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Exercise is one of the external factors associated with impairment of intestinal integrity, possibly leading to increased permeability and altered absorption. Here, we aimed to examine to what extent endurance exercise in the glycogen‐depleted state can affect intestinal permeability toward small molecules and protein‐derived peptides in relation to markers of intestinal function. Eleven well‐trained male volunteers (27 ± 4 years) ingested 40 g of casein protein and a lactulose/rhamnose (L/R) solution after an overnight fast in resting conditions (control) and after completing a dual – glycogen depletion and endurance – exercise protocol (first protocol execution). The entire procedure was repeated 1 week later (second protocol execution). Intestinal permeability was measured as L/R ratio in 5 h urine and 1 h plasma. Five‐hour urine excretion of betacasomorphin‐7 (BCM7), postprandial plasma amino acid levels, plasma fatty acid binding protein 2 (FABP‐2), serum pre‐haptoglobin 2 (preHP2), plasma glucagon‐like peptide 2 (GLP2), serum calprotectin, and dipeptidylpeptidase‐4 (DPP4) activity were studied as markers for excretion, intestinal functioning and recovery, inflammation, and BCM7 breakdown activity, respectively. BCM7 levels in urine were increased following the dual exercise protocol, in the first as well as the second protocol execution, whereas 1 h‐plasma L/R ratio was increased only following the first exercise protocol execution. FABP2, preHP2, and GLP2 were not changed after exercise, whereas calprotectin increased. Plasma citrulline levels following casein ingestion (iAUC) did not increase after exercise, as opposed to resting conditions. Endurance exercise in the glycogen depleted state resulted in a clear increase of BCM7 accumulation in urine, independent of DPP4 activity and intestinal permeability. Therefore, strenuous exercise could have an effect on the amount of food‐derived bioactive peptides crossing the epithelial barrier. The health consequence of increased passage needs more in depth studies.
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