Movement behaviors, that is, both physical activity and sedentary behavior, are independently associated with health risks. Although both behaviors have been investigated separately in people after stroke, little is known about the combined movement behavior patterns, differences in these patterns between individuals, or the factors associated with these patterns. Therefore, the objectives of this study are (1) to identify movement behavior patterns in people with first-ever stroke discharged to the home setting and (2) to explore factors associated with the identified patterns.
BackgroundEncouraging healthy eating behavior and increasing physical activity can improve health, vitality, and quality of life. Individuals and health professionals have specific needs and wishes. Creative technology allows personalization of blended lifestyle programs that support behavior change by presenting persuasive elements and self-regulation. However, the development of such personalized digital tools are time consuming and expensive. New research projects with regard to physical activity and/or nutrition that apply creative technology often start from scratch, while many of the core components are generic. Therefore, we aim to develop a modular platform that serves as a foundation to build several lifestyle applications for various populations, while taking into account the specific needs of the end users. To demonstrate how we can use the platform for a blended lifestyle program regarding physical activity and nutrition, the SONUTS application was developed. SONUTS helps older adults to maintain or lose weight while preserving muscle mass and function.Description of the applicationOur Modular E-health platform supports three end users: clients, health professionals, and researchers. It enables the use of various behavior change techniques such as goalsetting and action planning. The SO-NUTS application, that has been built on the platform, offers clients to track their dietary intake and physical activity, goal setting, evaluation, communication with health professional and in the future with members of the community. The health professional can track progress and can adjust goals when necessary. Data from both clients and health professionals can be retrieved by researchers, clients and professionals to determine effectiveness of the intervention.Practical description of demoWe will present a clickable demo version of the SO-NUTS application that was built on the modular platform. Moreover, we will show various options of the modular platform to demonstrate its use in the development of new applications for future research projects.
OBJECTIVES: The purpose of this controlled study is to document articulation and oromyofunctional behavior in children seeking orthodontic treatment. In addition, relations between malocclusions, articulation, and oromyofunctional behavior are studied. MATERIALS AND METHODS: The study included 56 children seeking orthodontic treatment. The control group, consisting of 54 subjects matched for age and gender, did not undergo orthodontic intervention. To determine the impact of the occlusion on speech, the Oral Health Impact Profile was used. Speech characteristics, intelligibility and several lip and tongue functions were analyzed using consensus evaluations. RESULTS: A significant impact of the occlusion on speech and more articulation disorders for/s,n,l,t/were found in the subjects seeking orthodontic treatment. Several other phenomena were seen more often in this group, namely more impaired lip positioning during swallowing, impaired tongue function at rest, mouth breathing, open mouth posture, lip sucking/biting, anterior tongue position at rest, and tongue thrust. Moreover, all children with a tongue thrust showed an anterior tongue position at rest. CONCLUSIONS: Children seeking orthodontics have articulatory and oromyofunctional disorders. To what extent a combined orthodontic and logopaedic treatment can result in optimal oral health (i.e. perfect dentofacial unit with perfect articulation) is subject for further multidisciplinary research.
Goed slapen is van belang voor de gezondheid, de alertheid en stressreductie van mensen. Echter kampen veel mensen met slaapproblemen, waarbij chronisch slecht slapen kan leiden tot o.a. cognitieve problemen (depressie en dementie) en het heeft een negatief effect op de kwaliteit van leven. Kwaliteit van slapen hangt samen met hoe de slaap wordt ervaren en of iemand voldoende uitrust en tevreden is over de slaap, echter is 63% van de Nederlanders ontevreden over de eigen slaapkwaliteit. Dit project richt zich op volwassenen met slaapproblemen. Door middel van co-creatie wordt er gewerkt aan een digitale slaapcoach, als verlengstuk van een slaapexpert. Uitgangspunt van de coach is de eerder ontwikkelde voedingscoach Halloliz. De nieuwe slaapcoach helpt bij het in kaart brengen van individuele factoren die de slaapkwaliteit verminderen, bij het verbeteren van slaapgedrag en bij het bestendigen hiervan. Er wordt gebruik gemaakt van Cognitive Behavior Therapy for Insomnia, waarbij het effect van interventies op slaapgedrag direct wordt verwerkt in een aangepast slaapplan. Het project richt zich op het ontwikkelen van een slaapcoach rekening houdend met adoptie en motivatie van de doelgroep om de coach te gebruiken. Adoptie hangt onder andere samen met de vorm en uitstraling van de slaapcoach, maar ook met de bereidheid van de gebruiker om het gedrag te veranderen. Daarnaast speelt motivatie een belangrijke rol bij het bestendigen van gedragsverandering. In het project wordt de patient journey in kaart gebracht en wordt uitgezocht hoe het ontwerp van de coach kan worden geoptimaliseerd richting adoptie, motivatie en uiteindelijk de gewenste gedragsverandering. Een consortium van experts in het ontwerpen (co-creatie) van eHealth oplossingen en gebruikersonderzoek zal het project uitvoeren. Deze worden bijgestaan door een klankbordgroep bestaande uit onder andere slaapexperts.
CRISPR/Cas genome engineering unleashed a scientific revolution, but entails socio-ethical dilemmas as genetic changes might affect evolution and objections exist against genetically modified organisms. CRISPR-mediated epigenetic editing offers an alternative to reprogram gene functioning long-term, without changing the genetic sequence. Although preclinical studies indicate effective gene expression modulation, long-term effects are unpredictable. This limited understanding of epigenetics and transcription dynamics hampers straightforward applications and prevents full exploitation of epigenetic editing in biotechnological and health/medical applications.Epi-Guide-Edit will analyse existing and newly-generated screening data to predict long-term responsiveness to epigenetic editing (cancer cells, plant protoplasts). Robust rules to achieve long-term epigenetic reprogramming will be distilled based on i) responsiveness to various epigenetic effector domains targeting selected genes, ii) (epi)genetic/chromatin composition before/after editing, and iii) transcription dynamics. Sustained reprogramming will be examined in complex systems (2/3D fibroblast/immune/cancer co-cultures; tomato plants), providing insights for improving tumor/immune responses, skin care or crop breeding. The iterative optimisations of Epi-Guide-Edit rules to non-genetically reprogram eventually any gene of interest will enable exploitation of gene regulation in diverse biological models addressing major societal challenges.The optimally balanced consortium of (applied) universities, ethical and industrial experts facilitates timely socioeconomic impact. Specifically, the developed knowledge/tools will be shared with a wide-spectrum of students/teachers ensuring training of next-generation professionals. Epi-Guide-Edit will thus result in widely applicable effective epigenetic editing tools, whilst training next-generation scientists, and guiding public acceptance.
A world where technology is ubiquitous and embedded in our daily lives is becoming increasingly likely. To prepare our students to live and work in such a future, we propose to turn Saxion’s Epy-Drost building into a living lab environment. This will entail setting up and drafting the proper infrastructure and agreements to collect people’s location and building data (e.g. temperature, humidity) in Epy-Drost, and making the data appropriately available to student and research projects within Saxion. With regards to this project’s effect on education, we envision the proposal of several derived student projects which will provide students the opportunity to work with huge amounts of data and state-of-the-art natural interaction interfaces. Through these projects, students will acquire skills and knowledge that are necessary in the current and future labor-market, as well as get experience in working with topics of great importance now and in the near future. This is not only aligned with the Creative Media and Game Technologies (CMGT) study program’s new vision and focus on interactive technology, but also with many other education programs within Saxion. In terms of research, the candidate Postdoc will study if and how the data, together with the building’s infrastructure, can be leveraged to promote healthy behavior through playful strategies. In other words, whether we can persuade people in the building to be more physically active and engage more in social interactions through data-based gamification and building actuation. This fits very well with the Ambient Intelligence (AmI) research group’s agenda in Augmented Interaction, and CMGT’s User Experience line. Overall, this project will help spark and solidify lasting collaboration links between AmI and CMGT, give body to AmI’s new Augmented Interaction line, and increase Saxion’s level of education through the dissemination of knowledge between researchers, teachers and students.
