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E-learning, B-learning en Lifelong Learning : ontwikkelingen in leren en onderwijs

De ontwikkelingen en veranderingen in de gezondheidszorg maken het noodzakelijk dat verpleegkundigen door middel van bij- en nascholing hun deskundigheid op peil houden. Deskundigheid is de basis waarop herregistratie in het BIG-register zal gaan plaatsvinden. Per 1 januari 2009 moeten zorgverleners na vijf jaar hun deskundigheid aantonen door te voldoen aan de werkervaringseis en, als ze daar niet aan voldoen, de scholingseis1. Deskundigheidsbevordering en Lifelong Learning - levenslang leren - gaan hand in hand. Lifelong Learning is het principe dat mensen gedurende hun hele leven in staat en gemotiveerd zijn om te leren en dat de omgeving daartoe mogelijkheden biedt2, 3. E-learning wordt geassocieerd met leeractiviteiten die plaatsvinden op een zelfgekozen moment waarbij een met een computernetwerk verbonden computer interactief gebruikt wordt. ‘Any place, any time’ is een wezenlijk aspect van e-learning. E-learning is belangrijk voor het levenslang leren van verpleegkundigen.

Hogere verwachtingen van technologie dan van elkaar?

Boekbespeking van Sherrie Turkle, 2011, Alone Together: Why We Expect More from Technology and Less from Each Other. New York: Basic Books. Mails, sms’jes, instant messages, tweets, Skype, voicemails, Facebookberichten – via smartphones en andere apparaten zijn we vrijwel non-stop in contact met vrienden en anderen. Via chatboxen en games ontmoeten we nieuwe vrienden en voor wie graag nog meer contact wil zijn er de elektronische apparaten die graag met ons willen praten. In Amerikaanse verzorgingshuizen kletsen sociable robots lekker aan tegen demente bejaarden. Het Japanse hotel Ohnoya biedt tweepersoonskamers aan voor alleenstaande mannen en hun digitale vriendin, inclusief dubbel gedekte dinertafels. In Nederland (en elders) speelden kinderen reeds eind jaren negentig met robothuisdieren als Furby en Tamagotchi, en laat de nieuwste iPhone-knuffel Talking Carl na een aai over zijn buikje graag merken hoezeer hij is gesteld op zijn relatie met jou.

Interview met Mieke Gerritzen over Help jezelf!

Moderne technologie als metafoor

Excerpt van de oratie van prof. dr. G. van der Laan als lector aan de Fontys hogescholen te Eindhoven (sociaal werk).

Between hope and fear: Distinctiveness of media accountability online in The Netherlands

News media in The Netherlands show great variety in the extent and ways, in which they realize media accountability online in terms of actor transparency, product transparency and feedback opportunities online. It is suggested that even those news rooms that seem to adhere to transparency and public accountability still need to explore the functionality and application of media accountability instruments (MAI). Both in terms of potentials and pitfalls, news rooms need to consider about what they want to be transparent and in what ways. To the extent that online innovations are visible, traditional news media seem to experiment, as is the case with newsroom blogs or the project of hyper local journalism Dichtbij.nl, part of the Telegraaf Company. Various news media have on-going projects on audience participation, online applications and distribution models. However, since many projects merely aim at finding new applications, processes, platforms and business models, it remains to be seen assess whether projects are indeed reasonably innovative and feasible at the same time. The development of an online and therefore immediate, archived, personalized and interactive context, offers practical and ethical challenges to Dutch journalism. These challenges bring shifts in its role and responsibility to society. It means that changes occur in what journalists are accountable for, as well as ways in how they are accountable. The Dutch media landscape lodges various professional accountability instruments like the press council and both profession-wide and news media specific codes of ethics, but some of these instruments receive only moderate support. Proactive openness is more an exception than the rule and may well be a distinctive indicator for quality journalism. Although news media often acknowledge the importance of media accountability offline and online, they often lack the resources or courage to use them or have different priorities. This ambiguous position may indicate that in relation to media accountability online, Dutch news media are between hope and fear: that it will either improve their relationship with the public and fuel professional quality, or ask too much of resources with too little benefit.

New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase

Hyperhomocysteinemia is a risk factor for cardiovascular disease, neurological disorders, and bone abnormalities. The key enzyme in homocysteine metabolism, cystathionine-β-synthase (CBS) is recognized as a target for new homocysteine-lowering therapies including enzyme replacement and gene therapy. Currently, there are no pharmacotherapies available that enhance CBS activity through its allosteric mechanism. The only known allosteric activator of CBS is S-adenosyl-L-methionine (SAM), which is available as a food supplement, but its effectiveness is limited by low membrane permeability and universal involvement in methylation reactions as a substrate. The discovery of CBS activators in high-throughput screening is challenging due to a lack of dedicated assays. Available HTS-compatible activity assays for CBS rely on measuring the product hydrogen sulfide or methanethiol where the signal increases with increased CBS activity. In the case of fluorescence-based assays, it is challenging to discern activators from autofluorescent compounds. In this study, we introduce a homocysteine consumption assay for isolated human CBS (HconCBS) based on the absorbance of Ellman's reagent. This assay leverages a decrease in signal upon CBS activation, with performance parameters exceeding the requirements for high-throughput screening. In a commercial library of 3010 compounds, the HconCBS assay identified 10 hit compounds as more active than SAM, whereas a fluorescence-based assay using 7-azido-4-methylcoumarin (AzMC) identified 141 hits. HconCBS identified 101 compounds with autoabsorbance which did not include hit compounds, while the fluorescence-based assay identified 383 autofluorescent compounds which included all hit compounds. While 4 out of 10 HconCBS hits were confirmed when purchased from a new source, the compounds affected homocysteine rather than CBS. Nevertheless, HconCBS consistently detected the CBS activator seleno-adenosyl-L-methionine (SeAM) added to 4 library plates and re-discovered the same library hits in 3 out of 4 re-screened plates. Taken together, HconCBS was designed to enable the discovery of allosteric CBS activators with greater reliability than fluorescence-based methods. Despite identifying some compounds that acted on homocysteine rather than CBS, the assay consistently identified the CBS activators SAM and SeAM and demonstrated reproducibility across two screening rounds. These findings establish HconCBS as a valuable tool for identifying potential therapeutic candidates for hyperhomocysteinemia, addressing a key gap in the development of CBS-targeted pharmacotherapies.