Abstract: AI tools in radiology are revolutionising the diagnosis, evaluation, and management of patients. However, there is a major gap between the large number of developed AI tools and those translated into daily clinical practice, which can be primarily attributed to limited usefulness and trust in current AI tools. Instead of technically driven development, little effort has been put into value-based development to ensure AI tools will have a clinically relevant impact on patient care. An iterative comprehensive value evaluation process covering the complete AI tool lifecycle should be part of radiology AI development. For value assessment of health technologies, health technology assessment (HTA) is an extensively used and comprehensive method. While most aspects of value covered by HTA apply to radiology AI, additional aspects, including transparency, explainability, and robustness, are unique to radiology AI and crucial in its value assessment. Additionally, value assessment should already be included early in the design stage to determine the potential impact and subsequent requirements of the AI tool. Such early assessment should be systematic, transparent, and practical to ensure all stakeholders and value aspects are considered. Hence, early value-based development by incorporating early HTA will lead to more valuable AI tools and thus facilitate translation to clinical practice. Clinical relevance statement: This paper advocates for the use of early value-based assessments. These assessments promote a comprehensive evaluation on how an AI tool in development can provide value in clinical practice and thus help improve the quality of these tools and the clinical process they support. Key Points: Value in radiology AI should be perceived as a comprehensive term including health technology assessment domains and AI-specific domains. Incorporation of an early health technology assessment for radiology AI during development will lead to more valuable radiology AI tools. Comprehensive and transparent value assessment of radiology AI tools is essential for their widespread adoption.
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BackgroundTo use advanced medical technologies (AMTs) correctly and safely requires both specialist knowledge and skills, and an awareness of risks and how those can be minimized. Reporting safety concerns about AMTs in home care can contribute to an improved quality of care. The extent to which a health care organization has integrated the reporting, evaluation and learning from incidents is a key element of that organization's patient safety culture.ObjectivesTo explore nurses' experiences regarding the education followed in the use of AMTs in the home setting, and their organizations' systems of reporting.DesignDescriptive cross-sectional design.Methods209 home care nurses from across the Netherlands who worked with infusion therapy, parenteral nutrition and/or morphine pumps responded to the online questionnaire between July 2018 and February 2019. The analysis of the data was mainly descriptive.ResultsEducational interventions that are most often used to learn how to use AMTs were, as an average over the three AMTs, instruction by a nurse (71%), practical training in the required skills (71%) and acquiring information to increase theoretical knowledge (69%). Considerable attention is paid to patient safety (88%) and the home setting (89%). However, a substantial proportion of the nurses (up to 29%) use AMTs even though they had not been tested on their skills. 95% of the respondents were well acquainted with the incident reporting protocol of their organization, but only 49% received structural or regular feedback on any actions taken as a result of event reporting.ConclusionsThis study revealed aspects of nurses' education that imply risk factors for patient safety. Practical training is not always given, additional or retraining is often voluntary, and the required skills are not always tested. However, the results show that nurses do have a good awareness of patient safety. Incidents are mainly discussed within the team, but less at the organizational level.
Nearly all waterborne products, such as food, beverages, pharmaceuticals, paints, biological (medical) samples, cosmetics and wood require preservation to prevent decomposition of the product due to microbial growth. Most non-food preservatives such as isothiazolinones, bronopol, and pyrithiones, are derived from oil and are increasingly more strictly regulated due to hazards such as ecotoxicity, sensibilization and development of allergies. The low legally permitted concentrations will not only become too low to realize preservation, they will also induce antimicrobial resistance. A chemical transition towards new, innovative, biobased, and eco-friendly preservatives is therefore required. Wydo NBD is dedicated to research towards sustainable ingredients for waterborne paints. For this, together with the Hanze University, non-hazardous, eco-friendly and biobased natural preservatives will be identified and further developed towards marketable products. The knowledge obtained in this project will contribute to the development of biological (paint) conservatives knowledge and improvement of current production methods of Wydo, with the potential for wider application in food and medical products. This project aims to identify natural antimicrobial additives and consists of three consecutive stages. First, an extensive, unbiased bioinformatics guided literature mining will be performed to find relationships between biological antimicrobial compounds and microbes found in paint. The most promising antimicrobials from this mining will be made available by chemical synthesis. Subsequently, the compounds will be assessed for their potential as novel natural preservatives for waterborne paints, by testing for their antimicrobial activity and stability.
Nearly all waterborne products, such as food, beverages, pharmaceuticals, paints, biological (medical) samples, cosmetics and wood require preservation to prevent decomposition of the product due to microbial growth. Most non-food preservatives such as isothiazolinones, bronopol, and pyrithiones, are derived from oil and are increasingly more strictly regulated due to hazards such as ecotoxicity, sensibilization and development of allergies. The low legally permitted concentrations will not only become too low to realize preservation, they will also induce antimicrobial resistance. A chemical transition towards new, innovative, biobased, and eco-friendly preservatives is therefore required. Wydo NBD is dedicated to research towards sustainable ingredients for waterborne paints. For this, together with the Hanze University, non-hazardous, eco-friendly and biobased natural preservatives will be identified and further developed towards marketable products. The knowledge obtained in this project will contribute to the development of biological (paint) conservatives knowledge and improvement of current production methods of Wydo, with the potential for wider application in food and medical products.This project aims to identify natural antimicrobial additives and consists of three consecutive stages. First, an extensive, unbiased bioinformatics guided literature mining will be performed to find relationships between biological antimicrobial compounds and microbes found in paint. The most promising antimicrobials from this mining will be made available by chemical synthesis. Subsequently, the compounds will be assessed for their potential as novel natural preservatives for waterborne paints, by testing for their antimicrobial activity and stability
