In this article, we explain how we envision the further interconnection of existing initiatives of online local memory collecting into a new social infrastructure, that is beneficial to the whole of Amsterdam. Three examples of local memory websites show how large districts in the East, South and West are represented thoroughly by local residents, in spite of differences in organizational characteristics. The concept of empowerment, as a multilevel construct, lends itself to frame these examples as important building blocks of socially sustainable districts and neighborhoods. Local knowledge, experiences and people become connected across Amsterdam when local memory websites become interconnected, by introducing city-wide compelling themes. Discussing this social infrastructure in relation to the concept of smart cities, leads us to a plea for more research focus on sociably smart cities.
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The research in this dissertation explores the social significance of local memory websites. Local memory websites offer local residents a platform where they collect and share memories about particular places or experiences in their neighbourhoods and districts. Following a systematic review and a broad field study, a narrative approach is developed to study collective levels of empowerment within the ‘Memory of East’ and the ‘Memory of West’, both in Amsterdam. Two empirical questions steer a double case study: 1) ‘How does the organizational development influence the online dynamics?’ and 2) ‘What collective empowerment do the online dynamics express?’ With its stronger social capital, the Memory of East is more likely to resist official memory intuitions, commercial popular culture and local politics than the Memory of West. On the other hand, with its more inclusive character, the Memory of West is more representative for the broad cultural backgrounds of its inhabitants than the Memory of East. These findings are shown to be related to five organizational continuums on which both websites are plotted to indicate their crucial organizational differences. Apart from a claim about the theoretical value of this model, it is illustrated how it functions as a discursive tool for the core groups behind both websites.
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Online platforms for collecting local memories are often claimed to be a driving force of empowerment for individuals, groups and the community as a whole. Long term online participation especially plays a key role in the claims for empowerment on group and community level. However, the present research on local memory websites lacks empirical data to substantiate these claims and leaves aside questions about their wider presence, the way they are organized and how their particular structure and affordances enable online participation. To address these issues, we develop six analytical dimensions in order to analyse a comprehensive number of such sites, examining in particular their organizational and online participatory features. On the basis of a cross-sectional design including 80 cases from the Netherlands, the United Kingdom and various other countries, we show three types of websites can be distinguished, namely residential, institutional and associational. In addition, we find that the expectancy of online participation is maximized not only by organizational aspects that fosterautonomy, but also by characteristics that enlarge the sense of authenticity. Our findings also show a limited number of cases with a considerable level of online participation, which offers the empirical data for analysis in terms of empowerment on group and community level.Nevertheless, we conclude that in most cases the organizational characteristics and participatory affordances of the websites are not sufficient to produce empowerment on all levels.
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The exploration of the narrative nature of local memory websites in relation to empowerment theory produces new insights in the nested levels of analysis of both. Empowerment’s value orientation calls for a focus on strengths instead of weaknesses and, as such, requires specific language that accommodates the conviction that resources are locally available, instead of scarce. Consequently, empowerment theory describes resources as being present in processes and outcomes on interdependent psychological, organizational and communal levels. The application of the empowerment framework’s components to the theoretical outcomes and processes of local memory websites illuminates the connecting roles local narratives play as resources in empowerment. First of all, personal stories, community narratives and dominant cultural narratives influence and support each other across levels. Secondly, narratives spread local knowledge which leads to shared values and common believes for collectives on various levels. And thirdly, the sharing of narratives happens through social networks that manifest themselves on different levels, which, as such, facilitate sharing other resources. Based on these perspectives, we offer a simplified model for empowerment with a focus on the interdependencies between levels of networks. Against this background, we discuss relevant analytical perspectives as a departure point for the empirical exploration of unstudied relations between empowerment and local memory websites.
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Recente studies gebruiken een sterk variërende terminologie voor het benoemen van de opbrengsten van interventies met buurtverhalenwebsites. Onze literatuurstudie ordent deze terminologie tot drie meer eenduidige analyseniveaus, die naadloos aansluiten op het empowerment model: concepten op microniveau voor individuele opbrengsten, op mesoniveau voor groepsvoordelen en op macroniveau voor versterking van de gemeenschap. Op het macroniveau onderscheiden we drie concepten: collectief geheugen, cultureel burgerschap en gemeenschapskracht. Met betrekking tot alle niveaus zijn de beweringen in de huidige literatuur voornamelijk gebaseerd op offline data en bevatten zelden een analyse van online participatie. Deze eenzijdigheid wordt veroorzaakt door de focus op institutionele interventies, die vaak onbedoeld online participatie verhinderen. Desondanks, presenteert de literatuur het open en online karakter van buurtverhalenwebsites als de drijvende kracht voor empowerment, in het bijzonder op het meso- en macroniveau. Om de bestaande kennis op het gebied van buurtverhalenwebsites uit te breiden stellen we onderzoek voor dat de daadwerkelijke samenstelling van dit veld in kaart brengt en meer autonome initiatieven bestudeert.
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Animals can alter their foraging behavior through associative learning, where an encounter with an essential resource (e.g., food or a reproductive opportunity) is associated with nearby environmental cues (e.g., volatiles). This can subsequently improve the animal’s foraging efficiency. However, when these associated cues are encountered again, the anticipated resource is not always present. Such an unrewarding experience, also called a memory-extinction experience, can change an animal’s response to the associated cues. Although some studies are available on the mechanisms of this process, they rarely focus on cues and rewards that are relevant in an animal’s natural habitat. In this study, we tested the effect of different types of ecologically relevant memory-extinction experiences on the conditioned plant volatile preferences of the parasitic wasp Cotesia glomerata that uses these cues to locate its caterpillar hosts. These extinction experiences consisted of contact with only host traces (frass and silk), contact with nonhost traces, or oviposition in a nonhost near host traces, on the conditioned plant species. Our results show that the lack of oviposition, after contacting host traces, led to the temporary alteration of the conditioned plant volatile preference in C. glomerata, but this effect was plant species-specific. These results provide novel insights into how ecologically relevant memory-extinction experiences can fine-tune an animal’s foraging behavior. This fine-tuning of learned behavior can be beneficial when the lack of finding a resource accurately predicts current, but not future foraging opportunities. Such continuous reevaluation of obtained information helps animals to prevent maladaptive foraging behavior.
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Background: Children with difficulties in listening and understanding speech despite normal peripheral hearing, can be diagnosed with the diagnosis Auditory Processing Disorder (A). However, there are doubts about the validity of this diagnosis. The aim of this study was to examine the relation between the listening difficulties of children between 8 and 12 years with suspected A and the attention, working memory, nonverbal intelligence and communication abilities of these children.Material and methods: In this case-control study we examined 10 children who reported listening difficulties in spite of normal peripheral hearing (3 referred by speech-language pathologist in the Northern Netherlands, 6 by an audiological center in the Southern Netherlands and one by parental concern) and 21 typically developing children (recruitment through word of mouth and by the website Taalexpert.nl), ages 8;0 to 12;0 years. The parents of all children completed three questionnaires about history, behavioral symptoms of ADHD, and communication skills (Children’s Communication Checklist). Teachers of the children completed the Children’s Auditory Processing Performance Scale (CHAPPS). Children were assessed for auditory processing abilities (speech-in-noise, filtered speech, binaural fusion, dichotic listening), nonverbal intelligence (Raven’s Coloured Progressive Matrices), and working memory (Clinical Evaluation of Language Fundamentals). Auditory and visual attention was studied with four behavioral tests of the WAFF battery of the Vienna Test System (Schuhfried).Results: Preliminary analysis shows no differences between groups on the auditory processing tests and nonverbal intelligence quotient. Children in the experimental group have poorer communication performance (parent report), poorer listening skills (teacher report), and poorer working memory and attention skills (behavioral tests).Conclusions: The results of this study showed that there is a difference between children with listening complaints and typically developing children, but that the problems are not specific to the auditory modality. There seems to be no evidence for the validity of an auditory deficit.
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Introduction: Patient information holds an important role in knee arthroplasty surgery regarding patients’ expectations and outcomes after surgery. The purpose of the present study was to explore the experiences and opinions of patients undergoing knee arthroplasty (KA) surgery on an information brochure provided preoperatively. Methods: A qualitative case study of 8 patients using individual semi-structured interviews was conducted to explore patients’ opinions on an information brochure in KA surgery. Results: Patients rated the brochure as good and recommended its use. Unsatisfactory information regarding wound healing, pain expectations, postoperative exercises and use of walking aids was reported. Patients stated that the table of contents was insufficient and the size of the brochure (A4-format) too large. Patients reported to have no need for additional digital sources (e.g. applications, websites). Conclusion: These opinions support the use of an information brochure. The reported opinions were used to improve the brochure. Future research should focus on the improvement of information sources by involving patients (and other users) in the development process in which the information is tailored towards patient needs.
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Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of TNF-α is beneficial for the treatment of certain inflammatory diseases, total neutralization of TNF-α largely failed in the treatment of neurodegenerative diseases. TNF-α exerts distinct functions depending on interaction with its two TNF receptors, whereby TNF receptor 1 (TNFR1) is associated with neuroinflammation and apoptosis and TNF receptor 2 (TNFR2) with neuroprotection and immune regulation. Here, we investigated the effect of administering the TNFR1-specific antagonist Atrosimab, as strategy to block TNFR1 signaling while maintaining TNFR2 signaling unaltered, in an acute mouse model for neurodegeneration. In this model, a NMDA-induced lesion that mimics various hallmarks of neurodegenerative diseases, such as memory loss and cell death, was created in the nucleus basalis magnocellularis and Atrosimab or control protein was administered centrally. We showed that Atrosimab attenuated cognitive impairments and reduced neuroinflammation and neuronal cell death. Our results demonstrate that Atrosimab is effective in ameliorating disease symptoms in an acute neurodegenerative mouse model. Altogether, our study indicates that Atrosimab may be a promising candidate for the development of a therapeutic strategy for the treatment of neurodegenerative diseases.Keywords: Neuroimmunology ; Neurological disorders ; Pharmaceutics ; Tumour-necrosis factors
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