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Michael additions of α-nitroesters with enones and α,β-unsaturated aldehydes result in quantitative conversions to the corresponding 1,4-adducts by performing the reactions in water in the presence of ytterbium triflate as water-tolerant Lewis acid.
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In this article, we review the recent progress that has been made in the field of Lewis-acid catalysis of carbon carbon-bond-forming reactions in aqueous solution. Since water hampers the hard hard interactions between the catalyst and the reactant, it often complicates catalysis. However, once coordination has taken place, water can have beneficial effects on rates and selectivities of Lewis acid catalysed Diels Alder reactions, aldol reactions, allylation reactions, Barbier and Mannich type reactions as well as Michael additions.
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This research focuses on exit choices within SMEs. In this study, “exit choice” refers to the decision to opt for either liquidation or sale of the firm. The predictions focus on human-capital and firm-resource variables. The hypotheses are tested on a set of 158 owners of small firms, the majority of which are micro-firms with 0–9 employees. The results of a series of binominal logistic regression analyses show that firm-resource characteristics (previous sales turnover, the firm’s independence from its owner, and firm size), together with one aspect of the owner’s specific human capital (the owner’s acquisition experience), predict exit choice. The conclusions have been made with caution, as the dataset is relatively small and the number of predictors is limited.
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Journalists in the 21st century are expected to work for different platforms, gather online information, become multi‐media professionals, and learn how to deal with amateur contributions. The business model of gathering, producing and distributing news changed rapidly. Producing content is not enough; moderation and curation are at least as important when it comes to working for digital platforms. There is a growing pressure on news organizations to produce more inexpensive content for digital platforms, resulting in new models of low‐cost or even free content production. Aggregation, either by humans or machines ‘finding’ news and re‐publishing it, is gaining importance. At so‐called ‘content farms’ freelancers, part‐timers and amateurs produce articles that are expected to end up high in web searches. Apart from this low‐pay model a no‐pay model emerged were bloggers write for no compensation at all. At the Huffington Post thousands of bloggers actually work for free. Other websites use similar models, sometimes offering writers a fixed price depending on the number of clicks a page gets. We analyse the background, the consequences for journalists and journalism and the implications for online news organizations. We investigate aggregation services and content farms and no‐pay or low‐pay news websites that mainly use bloggers for input.
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ABSTRACT Background: We investigated if the addition of an inter-professional student-led medication review team (ISP-team) to standard care can increase the number of detected ADRs and reduce the number of ADRs 3 months after an outpatient visit. Research design and methods: In this controlled clinical trial, patients were allocated to standard care (control group) or standard care plus the ISP team (intervention group). The ISP team consisted of medical and pharmacy students and student nurse practitioners. The team performed a structured medication review and adjusted medication to reduce the number of ADRs. Three months after the outpatient visit, a clinical pharmacologist who was blinded for allocation performed a follow-up telephone interview to determine whether patients experienced ADRs. Results: During the outpatient clinic visit, significantly more (p < 0.001) ADRs were detected in the intervention group (n = 48) than in the control group (n = 10). In both groups, 60–63% of all detected ADRs were managed. Three months after the outpatient visit, significantly fewer (predominantly mild and moderately severe) ADRs related to benzodiazepine derivatives and antihypertensive causing dizziness were detected in the patients of the intervention group. Conclusions: An ISP team in addition to standard care increases the detection and management of ADRs in elderly patients resulting in fewer mild and moderately severe ADRs
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Vast empirical evidence underscores that exporting firms are more productive than non-exporters. As governments accordingly pursue export-promoting policies we are interested in the firmness of these conclusions with respect to African small and medium sized enterprises (SMEs) and the influence of the destination of export trade. Using a micro-panel dataset from five African countries we confirm the self-selection. We apply propensity scores to match exporters and use a difference-in-difference methodology to test if African SMEs experience productivity gains because of export participation. Results indicate that African firms significantly learn-by-exporting. Manufacturers obtain significant performance improvements due to internationalization although this effect is moderated by export destination. Firms that export outside Africa become more capital intensive and at the same time hire more workers. In contrast we find evidence that exporters within the African region significantly downsize in capital intensity. Results regarding skill-bias of internationally active firms are mixed, where exporters within the region expand in size and hire more relatively unskilled workers.
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Population ageing has been a focus of research since the 1960s (Michael et al. 2006), and it has become a domain of international discussions, debates and research throughout a myriad of disciplines including housing, urban planning and real estate (Buffel and Phillipson 2016, van Bronswijk 2015, Kort 2017). Kazak et al. (2017) described how the ageing population has a profound impact on the real estate market, which is transforming in terms of availability of retirement accommodation for older people including accessibility, adaptability, and the availability of single-floor dwellings. Older people usually have a strong connection with the environment they understand and know well (van Hoof et al. 2016), enabling them to spend the latter years of their life in a familiar setting, which, in turn, influences their self-confidence, independence and the potential to successfully age in place. Older people are encouraged to continue living in their homes a familiar environment to them, instead of moving to an institutional care facility, and this is referred to as “ageing-in-place” (van Hoof 2010). This can be supported by creating a functional and spatial structure of cities that are friendly to older people (van Hoof et al. 2018, van Hoof and Kazak 2018). In the domain of environmental design, a series of home modifications can be identified. The most frequently encountered measures in and around the home are adaptations to improve the accessibility of the home (i.e., removal of barriers such as thresholds, installation of stair lifts in multi-storey homes, and the replacement of bath tubs by walk-in showers,). Separately from these expensive measures and adaptations, simple handgrips can improve the accessibility, safety and mobility of older people (van Hoof et al. 2010, van Hoof et al. 2013). A further concern that should be considered within the living environment is the lack of storage space for wheeled walkers and mobility scooters (including a place to charge batteries) whilst living in an apartment block with limited space to manoeuvre on corridors (Kazak et al. 2017). However, with increasing demands for care, it is not always possible to remain living in one’s own home and moving into a residential or nursing facility is the only remaining option; whereby, specialist and/or nursing care can be accessed and provided in these living environments (van Hoof et al. 2009). Policy principles within long-term care aim to provide a home from home environment for their residents (Moise et al. 2004). Several specialised housing models have been developed in order to facilitate this person-centred care approach, as more traditional institutional settings often do not match with the new holistic and therapeutic goals (Verbeek 2017). Radical alterations have been made in comparison with traditional nursing homes, implementing changes in the organisational, physical and social environment of settings (Verbeek et al. 2009, van Hoof et al. 2009). For example, smaller groups of older people (six to seven persons) form a household, with nursing staff having integrated tasks, including assistance with activities of daily living, preparing meals, organising activities and doing household chores together with residents. Daily life is mainly determined by residents and nursing staff, and the physical environment resembles an archetypal house. With this distinct increase and popular notion of the role real estate plays in ageing-in-place and living well in old age, there is also a shifting focus regarding participation, activation, and helping each other. Home modifications and the home environment itself have a profound influence on the care provided and received at home. In short, the fewer barriers there are at home, the easier and less onerous responsibilities placed on the family carer(s) (Duijnstee 1992). Family carers themselves need such environmental interventions that support care, and a sense of community and belonging. Enabling one to age-in-place and to successfully age requires more than a simple occupational therapeutic approach of environmental interventions. It requires innovative new housing encompassing suitable technology arrangements that can facilitate and enable older adults to live comfortably into old age, preferably with others and offer family members (i.e., children, grandchildren and spouse). Furthermore, interconnecting technology into such environments can offer family members the option and opportunity to monitor their loved one remotely whilst all actors know there are additional safety barriers in place. This chapter discusses and provides innovative examples from a Dutch social housing association and their practices, which illustrates a new approach to environmental design that focuses more on building new communities in conjunction with the building itself, as opposed to the occupational therapeutic approaches and environmental support. First, we take a closer look at why we care for each other, which is the basis of the participation society, in which we must look after people who are near to us. This should ideally be at the basis of new housing arrangements -in which people are stimulated to meet, engage, survey and care- that social housing associations are developing, retrofitting and developing.
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In recent years, drones have increasingly supported First Responders (FRs) in monitoring incidents and providing additional information. However, analysing drone footage is time-intensive and cognitively demanding. In this research, we investigate the use of AI models for the detection of humans in drone footage to aid FRs in tasks such as locating victims. Detecting small-scale objects, particularly humans from high altitudes, poses a challenge for AI systems. We present first steps of introducing and evaluating a series of YOLOv8 Convolutional Neural Networks (CNNs) for human detection from drone images. The models are fine-tuned on a created drone image dataset of the Dutch Fire Services and were able to achieve a 53.1% F1-Score, identifying 439 out of 825 humans in the test dataset. These preliminary findings, validated by an incident commander, highlight the promising utility of these models. Ongoing efforts aim to further refine the models and explore additional technologies.
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