Live programming is a style of development characterized by incremental change and immediate feedback. Instead of long edit-compile cycles, developers modify a running program by changing its source code, receiving immediate feedback as it instantly adapts in response. In this paper, we propose an approach to bridge the gap between running programs and textual domain-specific languages (DSLs). The first step of our approach consists of applying a novel model differencing algorithm, tmdiff, to the textual DSL code. By leveraging ordinary text differencing and origin tracking, tmdiff produces deltas defined in terms of the metamodel of a language. In the second step of our approach, the model deltas are applied at run time to update a running system, without having to restart it. Since the model deltas are derived from the static source code of the program, they are unaware of any run-time state maintained during model execution. We therefore propose a generic, dynamic patch architecture, rmpatch, which can be customized to cater for domain-specific state migration. We illustrate rmpatch in a case study of a live programming environment for a simple DSL implemented in Rascal for simultaneously defining and executing state machines.
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Communicatie en media veranderen van structuur en inhoud nu onze samenleving zich transformeert naar een gedigitaliseerde netwerksamenleving. Alle bestaande spelers (overheden, bedrijven, culturele instellingen, burgers, etc.) gaan zich op nieuwe manieren tot elkaar verhouden. Betekenis en identiteit zijn hierin kernbegrippen waar actief mee geëxperimenteerd moet worden. Laboratorium Waterwolf richt zich actief en praktijkgericht op de veranderende rol van cultuur in deze nieuwe samenleving. Bestaande spelers moeten zichzelf opnieuw uitvindenklassieke 'zenders', werkend vanuit inhoudelijke autoriteit, zullen steeds vaker niet alleen zelf reflecteren en kennis ontwikkelen, maar juist een centrale rol spelen in het organiseren en inspireren van kennisontwikkeling en leerprocessen in de samenleving zelf. Dit schetsboek presenteert laboratorium Waterwolf: initiatiefnemers, partners, uitgangspunten, denkbeelden en onderzoeksagenda.
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In dit artikel (en keynote) schetst Nigten enkele grote veranderingen in onze samenleving en dagelijks leven en hoe dit samenhangt met onze kijk op techniek. Zij signaleert een verschuiving van techniek gestuurde innovatie naar innovatie door en met de eindgebruiker en hoe dit zich verhoudt tot technisch onderwijs. Vervolgens vergelijkt Nigten het procesverloop van grote sociale maatschappelijke innovaties met innovatie trajecten zoals we die kennen op het gebied van producten of diensten. Grote sociale innovatie trajecten vragen, net als radicale product- en diensteninnovaties, om andere organisatiemodellen dan het model waarin een product steeds verder verfijnd of verbeterd wordt. Om ons heen zien we dat de ROC opleidingen en de Hogescholen, moeite hebben met snel schakelen. De grote organisaties, de instituten hebben meestal niet de armslag om risico, een belangrijk aspect van innovatie, te nemen. Desondanks is het van groot belang dat de studenten toekomstbestendig onderwijs krijgen. Aan de hand van innovatie projecten van The Patching Zone, een transdisciplinair innovatie laboratorium in Rotterdam en het lectoraat PI aan de Hanze Hogeschool wordt er in dit artikel nader in gegaan op bruikbare innovatie modellen voor het technisch onderwijs. Hiervoor hanteert Nigten twee sleutelbegrippen: co-creatie en creativiteit en hoe deze die naadloos op elkaar aan kunnen sluiten.
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From teh UU repository: "Background: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and long-term efficacy. The use of non-digestible oligosaccharides might improve OIT efficacy since they are known to directly modulate intestinal epithelial and immune cells in addition to acting as prebiotics. Aim: To investigate whether a diet supplemented with plant-derived fructo-oligosaccharides (FOS) supports the efficacy of OIT in a murine cow's milk allergy model and to elucidate the potential mechanisms involved. Methods: After oral sensitization to the cow's milk protein whey, female C3H/HeOuJ mice were fed either a control diet or a diet supplemented with FOS (1% w/w) and received OIT (10 mg whey) 5 days a week for 3 weeks by gavage. Intradermal (i.d.) and intragastric (i.g.) challenges were performed to measure acute allergic symptoms and mast cell degranulation. Blood and organs were collected to measure antibody levels and T cell and dendritic cell populations. Spleen-derived T cell fractions (whole spleen-and CD25-depleted) were transferred to naive recipient mice to confirm the involvement of regulatory T cells (Tregs) in allergy protection induced by OIT + FOS. Results: OIT + FOS decreased acute allergic symptoms and mast cell degranulation upon challenge and prevented the challenge-induced increase in whey-specific IgE as observed in sensitized mice. Early induction of Tregs in the mesenteric lymph nodes (MLN) of OIT + FOS mice coincided with reduced T cell responsiveness in splenocyte cultures. CD25 depletion in OIT + FOS-derived splenocyte suspensions prior to transfer abolished protection against signs of anaphylaxis in recipients. OIT + FOS increased serum galectin-9 levels. No differences in short-chain fatty acid (SCFA) levels in the cecum were observed between the treatment groups. Concisely, FOS supplementation significantly improved OIT in the acute allergic skin response, %Foxp3+ Tregs and %LAP+ Th3 cells in MLN, and serum galectin-9 levels. Conclusion: FOS supplementation improved the efficacy of OIT in cow's milk allergic mice. Increased levels of Tregs in the MLN and abolished protection against signs of anaphylaxis upon transfer of CD25-depleted cell fractions, suggest a role for Foxp3+ Tregs in the protective effect of OIT + FOS. "
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The central aim of this dissertation is to increase our understanding of changes in identifications and in the professional identity of employees, by investigating the prominent foci of identification, their mix in higher-order social identities and the personal and organisational factors (HRM and supervisory behaviour) that are involved in the change of these professional self definitions. Building upon the assumption that institutions for Higher Education and their workforce are being continually challenged to keep up and adapt to changing societal demands and that it is the quality and flexibility of the workforce which is the key factor to address this turmoil, this dissertation specifically focuses on the understanding of changes in teachers’ professional identity in higher vocational education. For this purpose four related empirical studies have been conducted. Together these studies illustrate the considerable professional diversity in the workforce and shed light on the relationships between foci of identification and professional identities, performance appraisal, leadership, career competencies, customization strategies, professional development and changes in teachers’ identifications over time.
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Longitudinal criminological studies greatly improved our understanding of the longitudinal patterns of criminality. These studies, however, focused almost exclusively on traditional types of offending and it is therefore unclear whether results are generalizable to online types of offending. This study attempted to identify the developmental trajectories of active hackers who perform web defacements. The data for this study consisted of 2,745,311 attacks performed by 66,553 hackers and reported to Zone-H between January 2010 and March 2017. Semi-parametric group-based trajectory models were used to distinguish six different groups of hackers based on the timing and frequency of their defacements. The results demonstrated some common relationships to traditional types of crime, as a small population of defacers accounted for the majority of defacements against websites. Additionally, the methods and targeting practices of defacers differed based on the frequency with which they performed defacements generally.
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Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing. The aim of the present study was to investigate whether physiologically based kinetic (PBK) modeling-facilitated conversion of in vitro toxicity data is an adequate approach to predict in vivo cardiotoxicity in humans. To enable evaluation of predictions made, methadone was selected as the model compound, being a compound for which data on both kinetics and cardiotoxicity in humans are available. A PBK model for methadone in humans was developed and evaluated against available kinetic data presenting an adequate match. Use of the developed PBK model to convert concentration–response curves for the effect of methadone on human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) in the so-called multi electrode array (MEA) assay resulted in predictions for in vivo dose–response curves for methadone-induced cardiotoxicity that matched the available in vivo data. The results also revealed differences in protein plasma binding of methadone to be a potential factor underlying variation between individuals with respect to sensitivity towards the cardiotoxic effects of methadone. The present study provides a proof-of-principle of using PBK modeling-based reverse dosimetry of in vitro data for the prediction of cardiotoxicity in humans, providing a novel testing strategy in cardiac safety studies.
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Journalists in the 21st century are expected to work for different platforms, gather online information, become multi‐media professionals, and learn how to deal with amateur contributions. The business model of gathering, producing and distributing news changed rapidly. Producing content is not enough; moderation and curation are at least as important when it comes to working for digital platforms. There is a growing pressure on news organizations to produce more inexpensive content for digital platforms, resulting in new models of low‐cost or even free content production. Aggregation, either by humans or machines ‘finding’ news and re‐publishing it, is gaining importance. At so‐called ‘content farms’ freelancers, part‐timers and amateurs produce articles that are expected to end up high in web searches. Apart from this low‐pay model a no‐pay model emerged were bloggers write for no compensation at all. At the Huffington Post thousands of bloggers actually work for free. Other websites use similar models, sometimes offering writers a fixed price depending on the number of clicks a page gets. We analyse the background, the consequences for journalists and journalism and the implications for online news organizations. We investigate aggregation services and content farms and no‐pay or low‐pay news websites that mainly use bloggers for input.
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From the article: "Project execution in the construction industry faces major challenges, e.g. difficulty in coordination and cooperation. Operational procurement during project execution is no exception. In this paper we construct a maturity model, based on earlier work, consisting of six dimensions (goal, control, process, organization, information, technology) and five maturity stages (transactional-oriented, commercial-oriented, coordination, internal-optimized, external-optimized). The model can be used to determine the level of procurement maturity for each of the dimensions, and for the determination of a strategy for growth in the construction industry. With input from a major construction firm in the Netherlands, through simulating tooling, the model is evaluated for its contribution to growth in operational excellence. Results of the simulation show support for a relation between maturity growth and increased operational excellence." Recommended Citation Xing, Xiaochun; Versendaal, Johan; van den Akker, Marjan; and De Bevere, Bastiaan, "Maturity of Operational Procurement in the Construction Industry: A Business/IT-Alignment Perspective" (2011). BLED 2011 Proceedings. Paper 22. http://aisel.aisnet.org/bled2011/22 Affiliation: Xing Xiaochun - Swets Information Services, Netherlands; Johan Versendaal - Utrecht University, Netherlands; HU University of Applied Sciences, Netherlands; Marjan van den Akker - Utrecht University, Netherlands; Bastiaan De Bevere - Ballast Nedam, Netherlands.
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Hogescholen starten in 2022 met een eigen doctoraatstraject: het Professional Doctorate. Daarmee introduceert het hbo een nieuwe beroepsopleiding waarmee het de grenzen in de beroepspraktijk wil verleggen. Kandidaten worden opgeleid tot hooggekwalificeerde professionals die leren te interveniëren in complexe vraagstukken zoals de energietransitie of de gezondheidszorg. Belangrijke en noodzakelijke toevoeging Hogescholen zien een doctoraatstraject in het hbo als een belangrijke en noodzakelijke toevoeging binnen het hoger onderwijs stelsel. Het Professional Doctorate (PD) maakt een doorlopende leerlijn van bachelor via master tot doctorate in de beroepskolom mogelijk, en wordt nauw verbonden met het overige hbo-onderwijs. Doel is dat hbo bachelor- en masterstudenten in hun onderwijs de vruchten plukken van het onderzoek van PD-kandidaten naar de laatste ontwikkelingen in de beroepspraktijk. Daarmee is de introductie van het professional doctorate ook een investering in de bredere aansluiting van het hbo op de arbeidsmarkt.
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