Electromagnetic fields, or EMF, are ubiquitous in our daily life. Extremely low frequency magnetic fields (ELF MF) are generated by any device using electric current. Especially in workplace situations involving MRI scanners, welding equipment, induction heaters, and power plants, they are known for potentially high field strengths. These high field strengths may lead to adverse health effects if insufficient preventive measures are in place. This study investigates employees’ perceptions on work safety regarding EMF exposure. We held 15 semi-structured interviews in three different (non-nuclear) power plants in the Netherlands. We found that power plants in this study made ample use of fences and warning signs where needed, creating a safe working environment. Nevertheless, some workers perceive that there are vague regulations, organizational issues and lack of clarity on the properties of EMF. Participants also indicated that there is some room for improvement with respect to work safety meetings on EMF. Employees want to be informed about EMF and its potential health effects and mitigation methods, but their information need is limited and straightforward. A simple warning system, along with safety information on paper, may be sufficient. https://doi.org/10.1080/13669877.2020.1750459 LinkedIn: https://www.linkedin.com/in/john-bolte-0856134/
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This is an Accepted Manuscript of an article published by Taylor & Francis in INTERNATIONAL SPECTATOR on 31-01-2022, available online: https://www.tandfonline.com/doi/abs/10.1080/03932729.2021.2007610 In July 2015, after intense negotiations with its creditors, Greece received a bailout in exchange for fiscal restraint. The coalition government at that time, led by the left-wing SYRIZA party, elected on the basis of an anti-austerity platform, eventually accepted the prevalent austerity frames of the creditors. Through the aid of Q-method, an analysis of Greek opinion leaders’ views of the negotiation highlights that this outcome can be explained in two different ways. The first posits that the ideological overtones that ruling SYRIZA injected in its negotiation strategy exhibited a lack of socialisation and undermined Greece’s already weak bargaining position. The second focuses on the institutional status quo bias in the Eurogroup in Germany’s favour, which discourages any change in the Eurozone. These two views may have partly been influenced by questions of political accountability.
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Background: Adverse outcome pathway (AOP) networks are versatile tools in toxicology and risk assessment that capture and visualize mechanisms driving toxicity originating from various data sources. They share a common structure consisting of a set of molecular initiating events and key events, connected by key event relationships, leading to the actual adverse outcome. AOP networks are to be considered living documents that should be frequently updated by feeding in new data. Such iterative optimization exercises are typically done manually, which not only is a time-consuming effort, but also bears the risk of overlooking critical data. The present study introduces a novel approach for AOP network optimization of a previously published AOP network on chemical-induced cholestasis using artificial intelligence to facilitate automated data collection followed by subsequent quantitative confidence assessment of molecular initiating events, key events, and key event relationships. Methods: Artificial intelligence-assisted data collection was performed by means of the free web platform Sysrev. Confidence levels of the tailored Bradford-Hill criteria were quantified for the purpose of weight-of-evidence assessment of the optimized AOP network. Scores were calculated for biological plausibility, empirical evidence, and essentiality, and were integrated into a total key event relationship confidence value. The optimized AOP network was visualized using Cytoscape with the node size representing the incidence of the key event and the edge size indicating the total confidence in the key event relationship. Results: This resulted in the identification of 38 and 135 unique key events and key event relationships, respectively. Transporter changes was the key event with the highest incidence, and formed the most confident key event relationship with the adverse outcome, cholestasis. Other important key events present in the AOP network include: nuclear receptor changes, intracellular bile acid accumulation, bile acid synthesis changes, oxidative stress, inflammation and apoptosis. Conclusions: This process led to the creation of an extensively informative AOP network focused on chemical-induced cholestasis. This optimized AOP network may serve as a mechanistic compass for the development of a battery of in vitro assays to reliably predict chemical-induced cholestatic injury.
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