Search results

Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model

From teh UU repository: "Background: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and long-term efficacy. The use of non-digestible oligosaccharides might improve OIT efficacy since they are known to directly modulate intestinal epithelial and immune cells in addition to acting as prebiotics. Aim: To investigate whether a diet supplemented with plant-derived fructo-oligosaccharides (FOS) supports the efficacy of OIT in a murine cow's milk allergy model and to elucidate the potential mechanisms involved. Methods: After oral sensitization to the cow's milk protein whey, female C3H/HeOuJ mice were fed either a control diet or a diet supplemented with FOS (1% w/w) and received OIT (10 mg whey) 5 days a week for 3 weeks by gavage. Intradermal (i.d.) and intragastric (i.g.) challenges were performed to measure acute allergic symptoms and mast cell degranulation. Blood and organs were collected to measure antibody levels and T cell and dendritic cell populations. Spleen-derived T cell fractions (whole spleen-and CD25-depleted) were transferred to naive recipient mice to confirm the involvement of regulatory T cells (Tregs) in allergy protection induced by OIT + FOS. Results: OIT + FOS decreased acute allergic symptoms and mast cell degranulation upon challenge and prevented the challenge-induced increase in whey-specific IgE as observed in sensitized mice. Early induction of Tregs in the mesenteric lymph nodes (MLN) of OIT + FOS mice coincided with reduced T cell responsiveness in splenocyte cultures. CD25 depletion in OIT + FOS-derived splenocyte suspensions prior to transfer abolished protection against signs of anaphylaxis in recipients. OIT + FOS increased serum galectin-9 levels. No differences in short-chain fatty acid (SCFA) levels in the cecum were observed between the treatment groups. Concisely, FOS supplementation significantly improved OIT in the acute allergic skin response, %Foxp3+ Tregs and %LAP+ Th3 cells in MLN, and serum galectin-9 levels. Conclusion: FOS supplementation improved the efficacy of OIT in cow's milk allergic mice. Increased levels of Tregs in the MLN and abolished protection against signs of anaphylaxis upon transfer of CD25-depleted cell fractions, suggest a role for Foxp3+ Tregs in the protective effect of OIT + FOS. "

Criminalization of market actor behavior as regulatory tool

Het onderzoek dat ten grondslag ligt aan dit artikel onderzoekt hoe de overheid markten reguleert voor (financiële) producten en diensten teneinde falen van de markt te voorkomen. Het behandelt specifiek EU Richtlijn 2014/57/EU betreffende strafrechtelijke sancties voor marktmisbruik en de implementatie daarvan in Nederland en opvolgend gebruik door het Openbaar Ministerie en Autoriteit Financiële Markten en hun Convenant ter voorkoming van ongeoorloofde samenloop van bestuurlijke en strafrechtelijke sancties. Het beantwoord de vraag of deze richtlijn de ontwikkeling van effectief reguleren van de financiële markt bevordert of remt. De slotsom ten aanzien van de implementatie van Richtlijn 2014/57/EU is – kort gezegd – dat “slechts” het aantal jaren gevangenisstraf voor handel met voorkennis en marktmisbruik van twee naar vier aangepast dient te worden. Het artikel concludeert tenslotte dat de huidige praktijk van het Convenant tussen OM en Autoriteit Financiële Markten kan blijven bestaan. De Autoriteit Financiële Markten kan haar inspanningen om haar toezicht verder in de geest van responsive regulation te verbeteren ongestoord door het OM voortzetten.

Participatory experimentation with energy law: digging in a ‘regulatory sandbox’ for energy cooperatives and homeowners’ associations in the Netherlands

To facilitate energy transition, in several countries regulators have devised ‘regulatory sandboxes’ to create a participatory experimentation environment for exploring revision of energy law. These sandboxes allow for a two-way regulatory dialogue between an experimenter and an approachable regulator to innovate regulation and enable new socio-technical arrangements. We focus on the Dutch Energy Experimentation Decree (EED) that invites homeowners’ associations and energy cooperatives to propose projects prohibited by extant regulation. In order to localize, democratize and decentralize energy provision, local experimenters can, for instance, organise peer-to-peer supply and determine their own tariffs for energy transport.

Succesful transplantation of law

Regulatory Response to the Rise of Fintech Credit in The Netherlands

The rise of financial technology (fintech) driven business models in banking poses a challenge for financial regulators. While the positive effects on the banking sector in terms of greater diversity and competition are generally recognized and encouraged by regulators, the nature of fintech business models may increase the risk of financial instability. Regulators are exploring ways to resolve this dilemma. The paper in hand makes a contribution to the literature by providing a framework for resolving the dilemma that is evaluated in the context of the regulatory response to the rise of fintech credit in the Netherlands. The semi-structured interviews which we conducted with four senior Dutch regulators resulted in three areas that–from their perspective–required urgent action: fintech credit companies need to lower the risk of overlending, increase pricing transparency, and improve lending standards. These findings were confirmed by the results of they survey among fintech credit clients. The current regulatory response to the rise of fintech in banking in the Netherlands provides an interesting case study that delineates the features of the future regulation of fintech in banking.

Is government a right supervisor of the regulatory enforcement?

ABSTRACT. It is now generally accepted that the quality of the regulatory arrangements should be appraised not only by looking at the institutional design, but also by evaluating the factual enforcement and implementation of regulations. It is therefore advised that national governments take a more active stance in supervising the regulatory enforcement by different regulatory agencies. However, in some cases, government’s activism might be an impeding factor in regulatory enforcement. That this is not so crazy idea shows the analysis of the regulatory enforcement by Lithuanian Competition Authority in the area of competition policy during the years of integration to the European Union. For example, not only political and financial independence of the Competition Authority was difficult to establish, but also functions and competences of the regulatory agency were changed a number of times, which hampered the effectiveness of the agency’s performance while enforcing the competition law. In addition to often changes of functions, also the scope of competences was changing. As a result, the variety of tasks attributed to the Lithuanian Competition Authority caused the growing overload of work, which further hindered its regulatory practice. The question is who can be blamed for that? Was it just the inexperience of the government who was seeking for the best institutional design and could not stop with redesigning the regulatory agency or was it the intentional behaviour guided by some concrete interests as a result of a regulatory capture? The analysis of the regulatory enforcement during the period of 15 years does not allow for disregarding of the second possibility.