DOCUMENT
Dit najaar zijn de langverwachte nieuwe consensuscriteria voor hetvaststellen van ondervoeding en sarcopenie gepresenteerd. Het gaatom de internationale criteria voor de diagnose van ondervoeding ende herziene Europese consensus over de sarcopenie-definitie en decriteria voor diagnose. Beide worden internationaal gedragen en zullen wereldwijd worden aanbevolen als de nieuwe standaard
DOCUMENT
Voor het eerst in de geschiedenis van de mensheid zijn er meer mensen met overgewicht dan met ondervoeding. Overgewicht is in snel tempo toegenomen en is een van de grootste maatschappelijke (gezondheids)problemen van deze tijd. Overgewicht heeft ondervoeding overschaduwd. In "The land of plenty"’ is geen gebrek meer, en dus geen ondervoeding zou je verwachten. Ondervoeding blijkt echter ook in deze tijd nog steeds een van de grootste maatschappelijke (gezondheids). Door inactiviteit of door ziekte kan spiermassa afnemen en wordt het steeds lastiger ondervoeding door de laag vet heen te ontdekken. Het aanpakken van overgewicht en ondervoeding door de professional vergt goed gewichtsmanagement. Voeding en beweging spelen hierbij een cruciale rol. Energie uit de voeding is gerelateerd aan vetmassa, en eiwit uit de voeding en beweging is gerelateerd aan spiermassa
DOCUMENT
Het zorgpad ‘Voeding bij kanker’ beschrijft het (logistiek) pad dat de oncologische patiënt doorloopt binnen de voedingszorg vanaf het moment dat screening op behoefte aan voedingszorg plaatsvindt en verwijzing naar de diëtist tot en met follow-up of palliatieve fase. Hierbij zijn het format en de indeling aangehouden van de IKNL-formats van (niet-)tumorspecifieke zorgpaden
DOCUMENT
Background: Chronic low-grade inflammatory profile (CLIP) is one of the pathways involved in type 2 diabetes (T2D). Currently, there is limited evidence for ameliorating effects of combined lifestyle interventions on CLIP in type 2 diabetes. We investigated whether a 13-week combined lifestyle intervention, using hypocaloric diet and resistance exercise plus high-intensity interval training with or without consumption of a protein drink, affected CLIP in older adults with T2D. Methods: In this post-hoc analysis of the PROBE study 114 adults (≥55 years) with obesity and type 2 (pre-)diabetes had measurements of C-reactive protein (CRP), pro-inflammatory cytokines interleukin (IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte chemoattractant protein (MCP)-1, anti-inflammatory cytokines IL-10, IL-1 receptor antagonist (RA), and soluble tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and adiponectin, and glycation biomarkers carboxymethyl-lysine (CML) and soluble receptor for advanced glycation end products (sRAGE) from fasting blood samples. A linear mixed model was used to evaluate change in inflammatory biomarkers after lifestyle intervention and effect of the protein drink. Linear regression analysis was performed with parameters of body composition (by dual-energy X-ray absorptiometry) and parameters of insulin resistance (by oral glucose tolerance test). Results: There were no significant differences in CLIP responses between the protein and the control groups. For all participants combined, IL-1RA, leptin and adiponectin decreased after 13 weeks (p = 0.002, p < 0.001 and p < 0.001), while ratios TNF-α/IL-10 and TNF-α/IL-1RA increased (p = 0.003 and p = 0.035). CRP increased by 12 % in participants with low to average CLIP (pre 1.91 ± 0.39 mg/L, post 2.13 ± 1.16 mg/L, p = 0.006) and decreased by 36 % in those with high CLIP (pre 5.14 mg/L ± 1.20, post 3.30 ± 2.29 mg/L, p < 0.001). Change in leptin and IL-1RA was positively associated with change in fat mass (β = 0.133, p < 0.001; β = 0.017, p < 0.001) and insulin resistance (β = 0.095, p = 0.024; β = 0.020, p = 0.001). Change in lean mass was not associated with any of the biomarkers. Conclusion: 13 weeks of combined lifestyle intervention, either with or without protein drink, reduced circulating adipokines and anti-inflammatory cytokine IL-1RA, and increased inflammatory ratios TNF-α/IL-10 and TNF-α/IL-1RA in older adults with obesity and T2D. Effect on CLIP was inversely related to baseline inflammatory status.
DOCUMENT
Background: Weight loss is key to treatment of older adults with obesity and type 2 diabetes, but also a risk for muscle mass loss. This study investigated whether a whey protein drink enriched with leucine and vitamin D could preserve muscle mass and improve glycemic control during combined lifestyle intervention in this population. Methods: 123 older adults with obesity and type 2 diabetes were randomized into a 13-week lifestyle intervention with dietary advice and exercise, receiving either the enriched protein drink (test) or an isocaloric control (control). Muscle mass was assessed with dual-energy X-ray absorptiometry and glycemic control by oral glucose tolerance test. Statistical analyses were performed using a linear mixed model. Results: There was a nonsignificant increase in leg muscle mass (+0.28 kg; 95% CI, −0.01 to 0.56) and a significant increase in appendicular muscle mass (+0.36 kg; 95% CI, 0.005 to 0.71) and total lean mass (+0.92 kg; 95% CI, 0.19 to 1.65) in test vs. control. Insulin sensitivity (Matsuda index) also increased in test vs. control (+0.52; 95% CI, 0.07 to 0.97). Conclusions: Use of an enriched protein drink during combined lifestyle intervention shows beneficial effects on muscle mass and glycemic control in older adults with obesity and type 2 diabetes.
DOCUMENT
