from the article: The demand for a wireless CO2 solution is ever increasing. One of the biggest problems with the majority of commercial available CO2 sensors is the high energy consumption which makes them unsuitable for battery operation. Possible candidates for CO2 sensing in a low power wireless application are very limited and show a problematic calibration process. This study focuses on one of those EMF candidates, which is a Ag4RbI5 based sensor. This EMF sensor is based on the potentiometric principle and consumes no energy. The EMF cell was studied in a chamber where humidity, temperature and CO2 level could be controlled. This study gives an detailed insight in the different drift properties of the potentiometric CO2 sensor and a method to amplify the sensors signal. Furthermore, a method to minimize the several types of drift is given. With this method the temperature drift can be decreased by a factor 10, making the sensor a possible candidate for a wireless CO2 sensor network.
At the department of electrical and electronic engineering of Fontys University of Applied Sciences we are defining a real-life learning context for our students, where the crossover with regional healthcare companies and institutes is maximized. Our innovative educational step is based on openly sharing electronic designs for health related measurement modalities as developed by our students. Because we develop relevant reference designs, the cross fertilization with society is large and so the learning cycle is short.
Sensor technology is increasingly applied for the purpose of monitoring elderly’s Activities of Daily Living (ADL), a set of activities used by physicians to benchmark physical and cognitive decline. Visualizing deviations in ADL can help medical specialists and nurses to recognize disease symptoms at an early stage. This paper presents possible visualizations for identifying such deviations. These visualizations have been iteratively explored and developed with three different medical specialists to better understand which deviations are relevant according to the different medical specialisms and explore how these deviations should be best presented. The study results suggest that the participants found a monthly bar graph in which activities are represented by colours as the most suitable from the ones presented. Although the visualizations of every ADL was found to be more or less relevant by the different medical specialists, the preference for focusing on specific ADL’s varied from specialist to specialist.
Size measurement plays an essential role for micro-/nanoparticle characterization and property evaluation. Due to high costs, complex operation or resolution limit, conventional characterization techniques cannot satisfy the growing demand of routine size measurements in various industry sectors and research departments, e.g., pharmaceuticals, nanomaterials and food industry etc. Together with start-up SeeNano and other partners, we will develop a portable compact device to measure particle size based on particle-impact electrochemical sensing technology. The main task in this project is to extend the measurement range for particles with diameters ranging from 20 nm to 20 um and to validate this technology with realistic samples from various application areas. In this project a new electrode chip will be designed and fabricated. It will result in a workable prototype including new UMEs (ultra-micro electrode), showing that particle sizing can be achieved on a compact portable device with full measuring range. Following experimental testing with calibrated particles, a reliable calibration model will be built up for full range measurement. In a further step, samples from partners or potential customers will be tested on the device to evaluate the application feasibility. The results will be validated by high-resolution and mainstream sizing techniques such as scanning electron microscopy (SEM), dynamic light scattering (DLS) and Coulter counter.
Cell-based production processes in bioreactors and fermenters need to be carefully monitored due to the complexity of the biological systems and the growth processes of the cells. Critical parameters are identified and monitored over time to guarantee product quality and consistency and to minimize over-processing and batch rejections. Sensors are already available for monitoring parameters such as temperature, glucose, pH, and CO2, but not yet for low-concentration substances like proteins and nucleic acids (DNA). An interesting critical parameter to monitor is host cell DNA (HCD), as it is considered an impurity in the final product (downstream process) and its concentration indicates the cell status (upstream process). The Molecular Biosensing group at the Eindhoven University of Technology and Helia Biomonitoring are developing a sensor for continuous biomarker monitoring, based on Biosensing by Particle Motion. With this consortium, we want to explore whether the sensor is suitable for the continuous measurement of HCD. Therefore, we need to set-up a joint laboratory infrastructure to develop HCD assays. Knowledge of how cells respond to environmental changes and how this is reflected in the DNA concentration profile in the cell medium needs to be explored. This KIEM study will enable us to set the first steps towards continuous HCD sensing from cell culture conditions controlling cell production processes. It eventually generates input for machine learning to be able to automate processes in bioreactors and fermenters e.g. for the production of biopharmaceuticals. The project entails collaboration with new partners and will set a strong basis for subsequent research projects leading to scientific and economic growth, and will also contribute to the human capital agenda.
Low back pain is the leading cause of disability worldwide and a significant contributor to work incapacity. Although effective therapeutic options are scarce, exercises supervised by a physiotherapist have shown to be effective. However, the effects found in research studies tend to be small, likely due to the heterogeneous nature of patients' complaints and movement limitations. Personalized treatment is necessary as a 'one-size-fits-all' approach is not sufficient. High-tech solutions consisting of motions sensors supported by artificial intelligence will facilitate physiotherapists to achieve this goal. To date, physiotherapists use questionnaires and physical examinations, which provide subjective results and therefore limited support for treatment decisions. Objective measurement data obtained by motion sensors can help to determine abnormal movement patterns. This information may be crucial in evaluating the prognosis and designing the physiotherapy treatment plan. The proposed study is a small cohort study (n=30) that involves low back pain patients visiting a physiotherapist and performing simple movement tasks such as walking and repeated forward bending. The movements will be recorded using sensors that estimate orientation from accelerations, angular velocities and magnetometer data. Participants complete questionnaires about their pain and functioning before and after treatment. Artificial analysis techniques will be used to link the sensor and questionnaire data to identify clinically relevant subgroups based on movement patterns, and to determine if there are differences in prognosis between these subgroups that serve as a starting point of personalized treatments. This pilot study aims to investigate the potential benefits of using motion sensors to personalize the treatment of low back pain. It serves as a foundation for future research into the use of motion sensors in the treatment of low back pain and other musculoskeletal or neurological movement disorders.
