This collection of articles contains contributions to the research project ‘From Prevention to Resilience’ (FPtP). In this project, the research team has generated insights and tools for designers, policymakers, and other professionals to contribute to more resilient cities and neighborhoods. The point of departure was public space as a site for intervention, while learning from the ongoing developments revolving around the Covid-19 pandemic. During the early phases of the pandemic, governments initially focused on preventing the virus from spreading. Public spaces came to be seen as potential places for contamination. In response, fences, markings, and barrier tapes were put into place to orchestrate people’s movement and promote physical distance. With our research project, we explored the role that public space could play besides such often ad hoc preventive measures. What other challenges can public space tackle with regard to the various shocks and stressors that hit cities and neighborhoods, now and in the future? And how to tackle these challenges in an integral way? An integral approach to designing public spaces involves many disciplines, and it is to a great extent dependent on local governments’ take on public spaces. To this end, we asked relevant experts to share their disciplinary reflections on a design perspective we have developed in the FPtP project, called Human / Non-Human Public Spaces. An earlier version of this design perspective was handed over to experts to provide feedback from an urban climate adaptation perspective and from a governance and cultural change perspective. Stephanie Erwin and Jeroen Kluck provide concrete feedback on the design perspective and offer a discussion in relation to the field of urban climate resilience. Alex Straathof offers an essayistic text in which he reflects on some of the key notions of the design perspective, reflecting on some of the key notions of the design perspective based on cultural theory and his experience with interventions on the neighborhood level. In parallel, we commissioned two independent experts in the field of spatial development and governance to make a preliminary analysis of the impact of COVID-19 on the government perspectives on public spaces. Both experts were given the same question, but they applied different methods. Hugo Verschoor Plug conducted an analysis on two national policy documents and six ‘omgevingsvisies’ – i.e., strategies on spatial planning and the environment – of large and middle-sized cities: Amsterdam, Breda, The Hague, Groningen, Rotterdam and Zwolle. Denise Vrolijk was asked to interview professionals from a cross-section of Dutch Cities in order to obtain their perspectives on how local governments viewed the role of public spaces in relation to resilience. Together, these analyses provide an overview of the current state of affairs in public space and urban resilience. We thank the authors for sharing their expertise and insights and thereby contribute to the FPtR project. This project is funded by The Netherlands Organization for Health Research and Development (ZonMw), part of the subsidy round ‘COVID 19: Maatschappelijke Dynamiek’, project nr. 10430032010029.
MULTIFILE
Introduction: Patients with cancer receiving radio- or chemotherapy undergo many immunological stressors. Chronic regular exercise has been shown to positively influence the immune system in several populations, while exercise overload may have negative effects. Exercise is currently recommended for all patients with cancer. However, knowledge regarding the effects of exercise on immune markers in patients undergoing chemo- or radiotherapy is limited. The aim of this study is to systematically review the effects of moderate- and high-intensity exercise interventions in patients with cancer during chemotherapy or radiotherapy on immune markers. Methods: For this review, a search was performed in PubMed and EMBASE, until March 2023. Methodological quality was assessed with the PEDro tool and best-evidence syntheses were performed both per immune marker and for the inflammatory profile. Results: Methodological quality of the 15 included articles was rated fair to good. The majority of markers were unaltered, but observed effects included a suppressive effect of exercise during radiotherapy on some proinflammatory markers, a preserving effect of exercise during chemotherapy on NK cell degranulation and cytotoxicity, a protective effect on the decrease in thrombocytes during chemotherapy, and a positive effect of exercise during chemotherapy on IgA. Conclusion: Although exercise only influenced a few markers, the results are promising. Exercise did not negatively influence immune markers, and some were positively affected since suppressed inflammation might have positive clinical implications. For future research, consensus is needed regarding a set of markers that are most responsive to exercise. Next, differential effects of training types and intensities on these markers should be further investigated, as well as their clinical implications.
The number of people who combine work and unpaid care is increasing rapidly as more people need care, public and private care systems are progressively under pressure and more people are required to work for longer. Without adequate support, these working carers may experience detrimental effects on their well-being. To adequately support working carers, it is important to first understand the challenges they face. A scoping review was carried out, using Arksey and O’Malley's framework, to map the challenges of combining work and care and solutions described in the literature to address these challenges. The search included academic and grey literature between 2008 and 2018 and was conducted in April 2018, using electronic academic databases and reference list checks. Ninety-two publications were mapped, and the content analysed thematically. A conceptual framework was derived from the analysis which identified primary challenges (C1), directly resulting from combining work and care, primary solutions (S1) aiming to address these, secondary challenges (C2) resulting from solutions and secondary solutions (S2) aiming to address secondary challenges. Primary challenges were: (a) high and/or competing demands; (b) psychosocial/-emotional stressors; (c) distance; (d) carer's health; (e) returning to work; and (f) financial pressure. This framework serves to help those aiming to support working carers to better understand the challenges they face and those developing solutions for the challenges of combining work and care to consider potential consequences or barriers. Gaps in the literature have been identified and discussed.
Many Caribbean reefs have shifted from coral-dominated to algal-dominated ecosystems. The high algae cover reduces coral recruitment, making the reef unable to recover from other disturbances and resulting in flatter reefs with lower biodiversity. One of the reasons for the proliferation of algae is a mass die-off of the herbivorous sea urchin Diadema antillarum in the early 1980s. Natural recovery of Diadema populations is slow to non-existent, making active restoration of this important grazer a top priority in Caribbean coral reef management, especially since Diadema densities were reduced by another mass mortality event in 2022. The marine park organizations of Saba and St. Eustatius want to restore Diadema populations by restocking cultured individuals. However, important knowledge gaps need to be addressed before large numbers of Diadema can be restocked on the reef. Current culture methods can only produce a limited number of competent larvae. In addition, only 8% of the settlers survive and after restocking, survival on the reef is low as well. In the RAAK PRO Diadema II project, the bottlenecks in Diadema culture will be addressed by comparing larval survival across multiple culture methods and investigating the relation between larval size and post-settlement survival. Growing-out juveniles at sea is likely to help prepare them for life in the wild, while restocking at an optimal size might also increase survival. Finally, a thorough restocking site selection based on high shelter availability and settlement rates will increase the long-term Diadema densities. The acquired knowledge and developed practices will be verified in a larger scale restocking experiment involving at least 5000 Diadema urchins. By restoring Diadema populations through restocking, macroalgae will be more intensively removed and corals will have a chance to settle and to survive, increasing the ability of the reef to cope with other stressors.
