Insulin sensitivity and metabolic flexibility decrease in response to bed rest, but the temporal and causal adaptations in human skeletal muscle metabolism are not fully defined. Here, we use an integrative approach to assess human skeletal muscle metabolism during bed rest and provide a multi-system analysis of how skeletal muscle and the circulatory system adapt to short- and long-term bed rest (German Clinical Trials: DRKS00015677). We uncover that intracellular glycogen accumulation after short-term bed rest accompanies a rapid reduction in systemic insulin sensitivity and less GLUT4 localization at the muscle cell membrane, preventing further intracellular glycogen deposition after long-term bed rest. We provide evidence of a temporal link between the accumulation of intracellular triglycerides, lipotoxic ceramides, and sphingomyelins and an altered skeletal muscle mitochondrial structure and function after long-term bed rest. An intracellular nutrient overload therefore represents a crucial determinant for rapid skeletal muscle insulin insensitivity and mitochondrial alterations after prolonged bed rest.
This research is commissioned by the professorship Novel Proteins: Insects and Fish, Healthy, Sustainable and Safe (INVIS) and conducted with the aim to investigate the constraints that hinder the uptake of insect-based feed in the Dutch finfish aquaculture branch and advise upon how to initiate a transition within the branch to adopt insect meal in fish feed widely. This is a underlying report of the webinar Insect culture in the Netherlands for feed and food on January 19, 2021.
MULTIFILE
Blue-green roofs have been utilized and studied for their enhanced water storage capacity compared to conventional roofs or extensive green roofs. Nonetheless, research about the thermal effect of blue-green roofs is lacking. The goal of this research is to study the thermal effect of blue-green roofs in order to assess their potential for shielding the indoor environment from outdoor temperature extremes (cold- and heat-waves). In this field study, we examined the differences between blue-green roofs and conventional gravel roofs from the perspective of the roof surface temperatures and the indoor temperatures in the city of Amsterdam for late 20th century buildings. Temperature sensor (iButtons) values indicate that outside surface temperatures for blue-green roofs are lower in summer and fluctuate less during the whole year than temperatures of conventional roofs. Results show that for three warm periods during summer in 2021 surface substrate temperatures peaked on average 5°C higher for gravel roofs than for blue-green roofs. Second, during both warm and cold periods, the temperature inside the water crate layer was more stable than the roof surface temperatures. During a cold period in winter, minimum water crate layer temperatures remained 3.0 o C higher than other outdoor surface temperatures. Finally, also the variation of the indoor temperature fluctuations of locations with and without blue-green roofs have been studied. Locations with blue-green roofs are less sensitive to outside air temperature changes, as daily temperature fluctuations (standard deviations) were systematically lower compared to conventional roofs for both warm and cold periods.
The climate change and depletion of the world’s raw materials are commonly acknowledged as the biggest societal challenges. Decreasing the energy use and the related use of fossil fuels and fossil based materials is imperative for the future. Currently 40% of the total European energy consumption and about 45% of the CO2 emissions are related to building construction and utilization (EC, 2015). Almost half of this energy is embodied in materials. Developing sustainable materials to find replacement for traditional building materials is therefore an increasingly important issue. Mycelium biocomposites have a high potential to replace the traditional fossil based building materials. Mycelium is the ‘root network’ of mushrooms, which acts as a natural glue to bind biomass. Mycelium grows through the biomass, which functions simultaneously as a growth substrate and a biocomposite matrix. Different organic residual streams such as straw, sawdust or other agricultural waste can be used as substrate, therefore mycelium biocomposites are totally natural, non-toxic, biological materials which can be grown locally and can be composted after usage (Jones et al., 2018). In the “Building On Mycelium” project Avans University of Applied Sciences, HZ University of Applied Sciences, University of Utrecht and the industrial partners will investigate how the locally available organic waste streams can be used to produce mycelium biocomposites with properties, which make them suitable for the building industry. In this project the focus will be on studying the use of the biocomposite as raw materials for the manufacturing of furniture or interior panels (insulation or acoustic).
To decrease the environmental impact caused by the construction sector, biobased materials need to be further developed to allow better integration and acceptance in the market. Mycelium composites are innovative products, with intrinsic properties which rise the attention of architects, designers and industrial companies. Until now, research has focused on the mechanical properties of mycelium products. The aim has been improving their mechanical strength, to achieve wider application in the construction sector. Alongside this, to introduce mycelium composites to a wider market, the aesthetic experience of the public also needs to be considered. In the context of this proposal, it is argued that users of biobased products can shift their attitudes towards their surroundings by adjusting to the visual aesthetics within their environment or products they surround themselves with (Hekkert, 1997). This can be further attributed to colours which can be experienced as warm or cold, aggressive or inviting, leading to experiences that may include pleasure or displeasure indicating the future success of the bio based product. Mycelium composites can be used as building materials, but also as interior design materials, therefore visible to its user. It is to determine the appropriate methodologies to confer colour to mycelium composites that the companies Impershield and Dorable came together to form the consortium for the present project. The investigated ways are: 1. Through the preliminary colouring of fibres and their use as substrate for mycelium growth 2. The surface treatment of the final product. The Centre of Expertise BioBased Economy (CoEBBE) and the Centre of Applied Research for Art and Design (CARADT) will be guiding the research through their experience with mycelium composites. This project will lay the basis to enhance visual appearance of mycelium composites, with the utilization of natural pigments, natural paints and coatings.
The climate change and depletion of the world’s raw materials are commonly acknowledged as the biggest societal challenges. Decreasing the energy use and the related use of fossil fuels and fossil based materials is imperative for the future. Currently 40% of the total European energy consumption and about 45% of the CO2 emissions are related to building construction and utilization (EC, 2015). Almost half of this energy is embodied in materials. Developing sustainable materials to find replacement for traditional building materials is therefore an increasingly important issue. In the original RAAK-mkb project “Building On Mycelium” Avans University of Applied Sciences, HZ University of Applied Sciences, University of Utrecht, industrial partners, SME’s and branch organisation are investigating how locally available organic waste streams can be used to produce ‘mycelium biocomposites’. Mycelium biocomposites consist of two components: mycelium and biomass fibres. Mycelium is the ‘root network’ of mushrooms, which can act as a ‘natural glue’ to bind biomass. Mycelium grows through the biomass, which functions simultaneously as a growth substrate and a biocomposite matrix. Different organic residual streams such as straw, sawdust or other agricultural waste can be used as substrate, therefore mycelium biocomposites are totally natural, non-toxic, biological materials which can be grown locally and can be composted after usage. Therefore Mycelium biocomposites have a high potential to replace the traditional fossil based building materials. This Raak impuls 2020 project aims to create mycelium biocomposites with properties that make them suitable for the building industry. Specifically the use of the biocomposite as raw materials for the manufacturing of furniture or interior panels (insulation or acoustic).
