Autoimmune antibody profiling plays a prominent role in both classification and prognosis of systemic sclerosis (SSc). In the last years novel autoantibodies have been discovered and have become available in diagnostic assays. However, standardization in autoimmune serology is lacking, which may have a negative impact on the added value of autoantibodies in diagnosis and prognosis of SSc. In this paper we describe the comparison of commercially available diagnostic assays for the detection of SSc-associated autoantibodies and explored the coexistence of multiple SSc-associated autoantibodies within patients.
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Systemic sclerosis (SSc) is an autoimmune disease which is characterized by vasculopathy, tissue fibrosis and activation of the innate and adaptive immune system. Clinical features of the disease consists of skin thickening and internal organ involvement. Due to the heterogeneous nature of the disease it is difficult to predict disease progression and complications. Despite the discovery of novel autoantibodies associated with SSc, there is an unmet need for biomarkers for diagnosis, disease progression and response to treatment. To date, the use of single (surrogate) biomarkers for these purposes has been unsuccessful. Combining multiple biomarkers in to predictive panels or ultimately algorithms could be more precise. Given the limited therapeutic options and poor prognosis of many SSc patients, a better understanding of the immune-pathofysiological profiles might aid to an adjusted therapeutic approach. Therefore, we set out to explore immunological fingerprints in various clinically defined forms of SSc. We used multilayer profiling to identify unique immune profiles underlying distinct autoantibody signatures. These immune profiles could fill the unmet need for prognosis and response to therapy in SSc. Here, we present 3 pathophysiological fingerprints in SSc based on the expression of circulating antibodies, vascular markers and immunomodulatory mediators.
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Er bestaat een nauwe samenhang tussen de reuk- en smaakperceptie.Veel chemosensorische stoornissen die leiden tot eengestoorde smaak zijn in feite reukstoornissen. Aandacht vragendeoorzaken van chemosensorische stoornissen zijn veroudering, hetgebruik van medicamenten, natuurlijke eiwitten, het mondbrandsyndroom,nervustrauma’s, beluchtingsproblemen ter hoogte vanhet reukzintuig, beschadiging van het reukepitheel en oncologischeaandoeningen of de behandeling daarvan. Een chemosensorischestoornis heeft gevolgen voor het genot van voedingsmiddelenen het psychisch welbevinden, kan leiden tot gewichtsverlies ofgewichtstoename en tot te weinig inname van vitaminen en mineralen.De behandeling van een chemosensorische stoornis kanbestaan uit medicatie, een chirurgische correctie, verbetering vande mondgezondheid, reukrevalidatie en voedingsadviezen.
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