Wireless sensor networks are becoming popular in the field of ambient assisted living. In this paper we report our study on the relationship between a functional health metric and features derived from the sensor data. Sensor systems are installed in the houses of nine people who are also quarterly visited by an occupational therapist for functional health assessments. Different features are extracted and these are correlated with a metric of functional health (the AMPS). Though the sample is small, the results indicate that some features are better in describing the functional health in the population, but individual differences should also be taken into account when developing a sensor system for functional health assessment.
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Ambient activity monitoring systems produce large amounts of data, which can be used for health monitoring. The problem is that patterns in this data reflecting health status are not identified yet. In this paper the possibility is explored of predicting the functional health status (the motor score of AMPS = Assessment of Motor and Process Skills) of a person from data of binary ambient sensors. Data is collected of five independently living elderly people. Based on expert knowledge, features are extracted from the sensor data and several subsets are selected. We use standard linear regression and Gaussian processes for mapping the features to the functional status and predict the status of a test person using a leave-oneperson-out cross validation. The results show that Gaussian processes perform better than the linear regression model, and that both models perform better with the basic feature set than with location or transition based features. Some suggestions are provided for better feature extraction and selection for the purpose of health monitoring. These results indicate that automated functional health assessment is possible, but some challenges lie ahead. The most important challenge is eliciting expert knowledge and translating that into quantifiable features.
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IL22 is an important cytokine involved in the intestinal defense mechanisms against microbiome. By using ileum-derived organoids, we show that the expression of anti-microbial peptides (AMPs) and anti-viral peptides (AVPs) can be induced by IL22. In addition, we identified a bacterial and a viral route, both leading to IL22 production by T cells, but via different pathways. Bacterial products, such as LPS, induce enterocyte-secreted SAA1, which triggers the secretion of IL6 in fibroblasts, and subsequently IL22 in T cells. This IL22 induction can then be enhanced by macrophage-derived TNFα in two ways: by enhancing the responsiveness of T cells to IL6 and by increasing the expression of IL6 by fibroblasts. Viral infections of intestinal cells induce IFNβ1 and subsequently IL7. IFNβ1 can induce the expression of IL6 in fibroblasts and the combined activity of IL6 and IL7 can then induce IL22 expression in T cells. We also show that IL22 reduces the expression of viral entry receptors (e.g. ACE2, TMPRSS2, DPP4, CD46 and TNFRSF14), increases the expression of anti-viral proteins (e.g. RSAD2, AOS, ISG20 and Mx1) and, consequently, reduces the viral infection of neighboring cells. Overall, our data indicates that IL22 contributes to the innate responses against both bacteria and viruses.
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BACKGROUND: There are no validated assessment tools for evaluating quality of schoolwork task performance of children living in German-speaking Europe (GSE).OBJECTIVE: To determine whether the international age-normative means of the School Version of the Assessment of Motor and Process Skills (School AMPS) are valid for use in GSE.METHODS: The participants were 159 typically-developing children, 3-12 years, from GSE. We examined the proportions of School AMPS measures falling within ±2 standard deviation (SD) of the international age-normative means, and evaluated for significant group differences (p < 0.05) in mean School AMPS measures between the GSE sample and the international age-normative sample using one-sample Z tests. When significant mean differences were found, we evaluated if the differences were clinically meaningful.RESULTS: At least 95% of the GSE School AMPS measures fell within ±2 SD of the international age-normative means for the School AMPS. The only significant mean differences were for 6- (p < 0.01) and 8-year-olds (p = 0.02), and only the 6-year-old school process mean difference was clinically meaningful.CONCLUSIONS: Because the only identified clinically meaningful difference was associated with likely scoring error of one rater, the international age-normative means of the School AMPS appear to be valid for use with children in GSE.
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Meten is weten. Daar zijn we het allemaal over eens. Maar hoe zorg je er voor dat je op het goede moment en met het juiste meetinstrument een zinvolle meting doet? Meten is immers geen doel op zich. Onlangs kwam een nieuwe uitgave van het boek Meten in de praktijk: Stappenplan voor het gebruik van meetinstrumenten in de praktijk uit. Hoog tijd om stil te staan bij meten in de dagelijkse ergotherapiepraktijk en daar een stappenplan voor te presenteren.
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Objective: To report the study protocol and baseline characteristics of a prospective cohort study to evaluate longitudinal recovery trajectories of patients recovering from COVID-19 who have visited a primary care allied health professional. Design: Report of the protocol and baseline characteristics for a prospective cohort study with a mixed-methods approach. Patients: Patients recovering from COVID-19 treated by primary care dietitians, exercise therapists, occupational therapists, physical therapists and/or speech and language therapists in the Netherlands. Methods: The prospective study will measure primary outcome domains: participation, health-related quality of life, fatigue, physical functioning, and costs, at baseline, 3, 6, 9 and 12 months. Interviews, on the patients’ experiences with allied healthcare, will be held with a subsample of patients and allied health professionals. Results: The cohort comprises 1,451 patients (57% female, mean age 49 (standard deviation 13) years). Preliminary results for the study cohort show that 974 (67%) of the participants reported mild/moderate severity symptoms during the infection period and patients reported severe restrictions in activities of daily living compared with previous research in other patient populations. Both quantitative and qualitative, will provide insight into the recovery of patients who are treated by allied health professionals. Conclusion: In conclusion, this will be the first comprehensive study to longitudinally evaluate the recovery trajectories and related costs of patients recovering from COVID-19 who are treated by allied health professionals in the Netherlands. This study will provide evidence for the optimal strategy to treat patients recovering from COVID-19 infection, including which patients benefit, and to what extent, from treatment, and which factors might impact their recovery course over time. The preliminary results of this study demonstrated the severity of restrictions and complaints at the start of therapy are substantial.
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Chronic itching is a serious and uncomfortable condition. The scratch response might result in a vicious cycle of alternating itching and scratching. To develop psychological interventions for people suffering from chronic itching and to break the vicious itch-scratching-itch cycle, it is important to elucidate which environmental factors trigger itch sensations. Virtual reality (VR) techniques provide a useful tool to examine specific content characteristics in a three-dimensional (3D VR) environment and their influences on itch sensations and scratching behaviour. This article describes two experiments in which we focused on the effects of environmental information on itching and scratching behaviour. Additionally, in the second experiment, we examined the influence of having a chronic skin condition on sensitivity to itch induction. We found evidence for the importance of the content of audio–visual materials for the effectiveness in inducing feelings of itch in the observers. In both experiments, we observed significantly higher levels of perceived itch in the itch-inducing conditions than in the control condition. Moreover, the results showed that elevated levels of perceived itch were associated with an increase in scratching behaviours, which was especially salient in the contagious itch condition, in which perceived itch was accompanied by a significant increase in the number of scratches. Experiment 2 additionally showed increased perceived itch levels in participants who reported having a chronic skin condition, reflecting higher sensitivity to itch-inducing audio–visual stimuli in this group than in participants without a chronic skin condition. Based on the results we concluded that directing attention towards itch- or scratch aspects of related information in the environment and to the consequences for one’s own skin are effective tools to induce itch sensations and scratching behaviour. This knowledge provides tools for developing novel strategies in advising and treating people suffering from chronic itching and breaking the vicious itch-scratching-itch cycle.
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Aim: To investigate the effects of exercise on salivary concentrations of inflammatory markers by analyzing a panel of 25 inflammatory markers in subjects who had participated in bicycle ergometer tests varying in workload and hydration status. Methods: Fifteen healthy young men (20-35 years) had performed 4 different exercise protocols of 1 hour duration in a randomly assigned cross-over design, preceded by a rest protocol. Individual workloads depended on participant's pre-assessed individual maximum workload (Wmax): rest (protocol 1), 70% Wmax in hydrated (protocol 2) and dehydrated (protocol 3) state, 50% Wmax (protocol 4) and intermittent 85%/55% Wmax in 2 min blocks (protocol 5). Saliva samples were collected before (T0) and immediately after exercise (T1), and at several time points after exercise (2 hours (T3), 3 hours (T4), 6 hours (T5) and 24 hours (T6)). Secretory Leukocyte Protease Inhibitor (SLPI), Matrix Metallopeptidase-9 (MMP-9) and lactoferrin was analyzed using a commercial ELISA kit, a panel of 22 cytokines and chemokines were analyzed using a commercial multiplex immunoassay. Data was analyzed using a multilevel mixed linear model, with multiple test correction. Results: Among a panel of 25 inflammatory markers, SLPI concentrations were significantly elevated immediately after exercise in all protocols compared to rest and higher concentrations reflected the intensity of exercise and hydration status. MMP-9 showed a significant increase in the 70% Wmax dehydrated, 50% Wmax and intermittent protocols. Conclusions: Salivary concentrations of SLPI and MMP-9 seem associated with exercise intensity and hydration status and may offer non-invasive biomarkers to study (local) inflammatory responses to different exercise intensities in human studies. sa
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Maatschappelijke uitdagingen In toenemende mate vertrouwen we een deel van ethische besluitvorming aan smart-technology toe. Technologie heeft vaker dan ooit een ethische lading. Dit kan soms verregaande consequenties hebben voor consumenten, burgers of organisaties. Hoe zeker moet een algoritme zijn van haar zaak om een burger van fraude te beschuldigen? Hoeveel risico mag een chat-bot die financieel advies geeft een klant laten lopen? Wie mag bepalen hoe een algoritme op een sociaal media platform omgaat met desinformatie? Dergelijke vragen leiden tot belangrijke uitdagingen op het gebied van morele autoriteit, ethische besluitvorming, en morele strategievorming. Strategievorming in snel veranderend speelveld In zijn rede zal Bart pleiten om niet zozeer dé oplossing bij ethisch technologische vraagstukken te vinden, maar vooral een manier te zoeken om op een bestendige manier om te gaan met een snel veranderend speelveld. In veel gevallen lijken oplossingen in zowel de private als publieke sector voor techno-ethische vraagstukken korte-termijn gericht. En zijn het vaak maatregelen die snel en vooral zichtbaar een negatief effect van technologie proberen in te dammen. In zijn lectorale rede zal Bart ingaan op hoe belangrijk het erkennen en herkennen van ethische vraagstukken bij het programmeren van nieuwe technologie is. Maar ook hoe men de menselijke maat kan vangen én gebruiken als input in het ontwerp van nieuwe technologie. Er is volgens hem vooral een bestendige strategie nodig.
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tract Micro wind turbines can be structurally integrated on top of the solid base of noise barriers near highways. A number of performance factors were assessed with holistic experiments in wind tunnel and in the field. The wind turbines underperformed when exposed in yawed flow conditions. The theoretical cosθ theories for yaw misalignment did not always predict power correctly. Inverter losses turned out to be crucial especially in standby mode. Combination of standby losses with yawed flow losses and low wind speed regime may even result in a net power consuming turbine. The micro wind turbine control system for maintaining optimal power production underperformed in the field when comparing tip speed ratios and performance coefficients with the values recorded in the wind tunnel. The turbine was idling between 20%–30% of time as it was assessed for sites with annual average wind speeds of three to five meters per second without any power production. Finally, the field test analysis showed that inadequate yaw response could potentially lead to 18% of the losses, the inverter related losses to 8%, and control related losses to 33%. The totalized loss led to a 48% efficiency drop when compared with the ideal power production measured before the inverter. Micro wind turbine’s performance has room for optimization for application in turbulent wind conditions on top of noise barriers. https://doi.org/10.3390/en14051288
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