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How radiation influences atherosclerotic plaque development

Atherosclerosis is the development of lipid-laden plaques in arteries and is nowadays considered as an inflammatory disease. It has been shown that high doses of ionizing radiation, as used in radiotherapy, can increase the risk of development or progression of atherosclerosis. To elucidate the effects of radiation on atherosclerosis, we propose a mathematical model to describe radiation-promoted plaque evelopment. This model distinguishes itself from other models by combining plaque initiation and plaque growth, and by incorporating information from biological experiments. It is based on two consecutive processes: a probabilistic dose-dependent plaque initiation process, followed by deterministic plaque growth.

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How radiation influences atherosclerotic plaque development

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Boven titel staat vermeld: De symbiose van biologie en technologie. Zowel vanuit het Applied Science onderwijs als vanuit het werkveld kwam er meer vraag om biologische expertise toe te voegen aan het bestaande lectoraat Thin Films & Functional Materials.

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Construct validity of an adult pain observation scale for people with profound intellectual and multiple disabilities

Background: Objective assessment of pain-related behaviours is crucial in adults with profound intellectual and multiple disabilities. No standardised pain observation instrument that specifically focuses on this target group is currently available. A previous study identified 12 pain-related behaviours in these persons. This study aimed to develop a valid and reliable instrument based on these 12 pain-related behaviours to assess pain in these adults in daily situations. Method: Videos of 91 adults with profound intellectual and multiple disabilities in potentially painful daily situations were scored using the 12 pain-related behaviour items. Mokken scale analysis was used to determine the construct validity of these items. Results: Analysis resulted in a 9-item scale (H =.46, Rho =.70), which appeared to be sample independent for the variables of sex, age and level of motor functioning. Conclusion: A scale containing 9 items (APOS-PIMD) with reasonable construct validity and sufficient reliability was developed, which can be used to measure pain in adults with profound intellectual and multiple disabilities in daily situations.

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Learning with Interactive Virtual Math in the Classroom

Interactive Virtual Math (IVM) is a visualization tool to support secondary school students’ learning of dynamic functions situations graphs. The logbook-function allows teachers to get continuous and real-time assessment on classroom progress and of individual students’ learning process. In a teaching experiment involving four mathematics teachers and their students, we investigated how the tool was used by the students and by the teachers.

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Learning with Interactive Virtual Math in the Classroom

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Stuck Together

Through a correspondence between two scholars, this paper explores and critiques various ways in which scholars working in ethnography and cultural analysis frame and construct their methodology and object of study. Through the close reading of theoretical accounts of methodology in ethnography and cultural analysis, we examine how these accounts construct the relationship between the scholar and her object of study.We read these scholarly practices as protocols, referring to the ways in which accounts of methodology may be understood as rules/guidelines by which scholars in these fields conduct research. Protocol etymologically refers to protos (first) and kolla (glue). Through the figure of the protocol, we delineate how scholars in ethnography and cultural analysis themselves become implicated in giving accounts of their research methodologies. Somatechnics presents a thoroughly multi-disciplinary scholarship on the body, providing a space for research that critically engages with the ethico-political implications of a wide range of practices and techniques. The term ‘somatechnics’ indicates an approach to corporeality which considers it as always already bound up with a variety of technologies, techniques and technics, thus enabling an examination of the lived experiences engendered within a given context, and the effects that technologies, technés and techniques have on embodiment, subjectivity and sociality.

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Enhancing a simulation-based Allocator Software with machine learning and genetic algorithms for improving the gate assignment problem

Assigning gates to flights considering physical, operational, and temporal constraints is known as the Gate Assignment Problem. This article proposes the novelty of coupling a commercial stand and gate allocation software with an off-the-grid optimization algorithm. The software provides the assignment costs, verifies constraints and restrictions of an airport, and provides an initial allocation solution. The gate assignment problem was solved using a genetic algorithm. To improve the robustness of the allocation results, delays and early arrivals are predicted using a random forest regressor, a machine learning technique and in turn they are considered by the optimization algorithm. Weather data and schedules were obtained from Zurich International Airport. Results showed that the combination of the techniques result in more efficient and robust solutions with higher degree of applicability than the one possible with the sole use of them independently.

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Enhancing a simulation-based Allocator Software with machine learning and genetic algorithms for improving the gate assignment problem

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The Peaceable Commons

A Manifesto The group of some 17 participants interrupted the UDHR text in real time, infusing it with inclusive terminology, queering its binary language and expanding its gaze to other lifebeings, making it a manifesto for a new world. The newly formulated Universal Declaration of Human and More-Than-Human Rights and Responsibility for a New World would be the manifesto for an alliance of those who insisted on an end to capitalist practices and their destructive effects on the planet.

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A scuticociliate causes mass mortality of Diadema antillarum in the Caribbean Sea

Echinoderm mass mortality events shape marine ecosystems by altering the dynamics among major benthic groups. The sea urchin Diadema antillarum, virtually extirpated in the Caribbean in the early 1980s by an unknown cause, recently experienced another mass mortality beginning in January 2022. We investigated the cause of this mass mortality event through combined molecular biological and veterinary pathologic approaches comparing grossly normal and abnormal animals collected from 23 sites, representing locations that were either affected or unaffected at the time of sampling. Here, we report that a scuticociliate most similar to Philaster apodigitiformis was consistently associated with abnormal urchins at affected sites but was absent from unaffected sites. Experimentally challenging naïve urchins with a Philaster culture isolated from an abnormal, field-collected specimen resulted in gross signs consistent with those of the mortality event. The same ciliate was recovered from treated specimens postmortem, thus fulfilling Koch’s postulates for this microorganism. We term this condition D. antillarum scuticociliatosis.

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A scuticociliate causes mass mortality of Diadema antillarum in the Caribbean Sea

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The design and use of open online modules for blended learning in STEM education

Blended learning, a teaching format in which face-to-face and online learning is integrated, nowadays is an important development in education. Little is known, however, about its affordances for teacher education, and for domain specific didactical courses in particular. To investigate this topic, we carried out a design research project in which teacher educators engaged in a co-design process of developing and field-testing open online learning units for mathematics and science didactics. The preliminary results concern descriptions of the work processes by the design teams, of design heuristics, and of typical ways of collaborating. These findings are illustrated for the case of two of the designed online units on statistics didactics and mathematical thinking, respectively.

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Producten 13

How radiation influences atherosclerotic plaque development

Onderzoek dat ertoe doet!

Construct validity of an adult pain observation scale for people with profound intellectual and multiple disabilities

Learning with Interactive Virtual Math in the Classroom

Stuck Together

Enhancing a simulation-based Allocator Software with machine learning and genetic algorithms for improving the gate assignment problem

The Peaceable Commons

A scuticociliate causes mass mortality of Diadema antillarum in the Caribbean Sea

The design and use of open online modules for blended learning in STEM education

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Producten 13

How radiation influences atherosclerotic plaque development

Onderzoek dat ertoe doet!

Construct validity of an adult pain observation scale for people with profound intellectual and multiple disabilities

Learning with Interactive Virtual Math in the Classroom

Stuck Together

Enhancing a simulation-based Allocator Software with machine learning and genetic algorithms for improving the gate assignment problem

The Peaceable Commons

A scuticociliate causes mass mortality of Diadema antillarum in the Caribbean Sea

The design and use of open online modules for blended learning in STEM education