Car use in the sprawled urban region of Noord‐Brabant is above the Dutch average. Does this reflect car dependency due to the lack of competitive alternative modes? Or are there other factors at play, such as differences in preferences? This article aims to determine the nature of car use in the region and explore to what extent this reflects car dependency. The data, comprising 3,244 respondents was derived from two online questionnaires among employees from the High‐Tech Campus (2018) and the TU/e‐campus (2019) in Eindhoven. Travel times to work by car, public transport, cycling, and walking were calculated based on the respondents’ residential location. Indicators for car dependency were developed using thresholds for maximum commuting times by bicycle and maximum travel time ratios between public transport and car. Based on these thresholds, approximately 40% of the respondents were categorised as car‐dependent. Of the non‐car‐dependent respondents, 31% use the car for commuting. A binomial logit model revealed that higher residential densities and closer proximity to a railway station reduce the odds of car commuting. Travel time ratios also have a significant influence on the expected directions. Mode choice preferences (e.g., comfort, flexibility, etc.) also have a significant, and strong, impact. These results highlight the importance of combining hard (e.g., improvements in infrastructure or public transport provi-sion) and soft (information and persuasion) measures to reduce car use and car dependency in commuting trips.
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Abstract-Architecture Compliance Checking (ACC) is useful to bridge the gap between architecture and implementation. ACC is an approach to verify conformance of implemented program code to high-level models of architectural design. Static ACC focuses on the modular software architecture and on the existence of rule violating dependencies between modules. Accurate tool support is essential for effective and efficient ACC. This paper presents a study on the accuracy of ACC tools regarding dependency analysis and violation reporting. Seven tools were tested and compared by means of a custom-made test application. In addition, the code of open source system Freemind was used to compare the tools on the number and precision of reported violation and dependency messages. On the average, 74 percent of 34 dependency types in our custom-made test software were reported, while 69 percent of 109 violating dependencies within a module of Freemind were reported. The test results show large differences between the tools, but all tools could improve the accuracy of the reported dependencies and violations.
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SUMMARY Architecture compliance checking (ACC) is an approach to verify conformance of implemented program code to high-level models of architec tural design. Static ACC focuses on the modular software architecture and on the existence of rule violating dependencies between modules. Accurate tool support is essential for effective and efficient ACC. This paper presents a study on the accuracy of ACC tools regarding dependency analysis and violation reporting. Ten tools were tested and compare d by means of a custom-made benchmark. The Java code of the benchmark testware contains 34 different types of dependencies, which are based on an inventory of dependency types in object oriented program code. In a second test, the code of open source system FreeMind was used to compare the 10 tools on the number of reported rule violating dependencies and the exactness of the dependency and violation messages. On the average, 77% of the dependencies in our custom-made test software were reported, while 72% of the dependencies within a module of FreeMind were reported. The results show that all tools in the test could improve the accuracy of the reported dependencies and violations, though large differences between the 10 tools were observed. We have identified10 hard-to-detect types of dependencies and four challenges in dependency detection. The relevance of our findings is substantiated by means of a frequency analysis of the hard-to-detect types of dependencies in five open source systems. DOI: 10.1002/spe.2421
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Huntington’s disease (HD) and various spinocerebellar ataxias (SCA) are autosomal dominantly inherited neurodegenerative disorders caused by a CAG repeat expansion in the disease-related gene1. The impact of HD and SCA on families and individuals is enormous and far reaching, as patients typically display first symptoms during midlife. HD is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia. SCAs are mainly characterized by ataxia but also other symptoms including cognitive deficits, similarly affecting quality of life and leading to disability. These problems worsen as the disease progresses and affected individuals are no longer able to work, drive, or care for themselves. It places an enormous burden on their family and caregivers, and patients will require intensive nursing home care when disease progresses, and lifespan is reduced. Although the clinical and pathological phenotypes are distinct for each CAG repeat expansion disorder, it is thought that similar molecular mechanisms underlie the effect of expanded CAG repeats in different genes. The predicted Age of Onset (AO) for both HD, SCA1 and SCA3 (and 5 other CAG-repeat diseases) is based on the polyQ expansion, but the CAG/polyQ determines the AO only for 50% (see figure below). A large variety on AO is observed, especially for the most common range between 40 and 50 repeats11,12. Large differences in onset, especially in the range 40-50 CAGs not only imply that current individual predictions for AO are imprecise (affecting important life decisions that patients need to make and also hampering assessment of potential onset-delaying intervention) but also do offer optimism that (patient-related) factors exist that can delay the onset of disease.To address both items, we need to generate a better model, based on patient-derived cells that generates parameters that not only mirror the CAG-repeat length dependency of these diseases, but that also better predicts inter-patient variations in disease susceptibility and effectiveness of interventions. Hereto, we will use a staggered project design as explained in 5.1, in which we first will determine which cellular and molecular determinants (referred to as landscapes) in isogenic iPSC models are associated with increased CAG repeat lengths using deep-learning algorithms (DLA) (WP1). Hereto, we will use a well characterized control cell line in which we modify the CAG repeat length in the endogenous ataxin-1, Ataxin-3 and Huntingtin gene from wildtype Q repeats to intermediate to adult onset and juvenile polyQ repeats. We will next expand the model with cells from the 3 (SCA1, SCA3, and HD) existing and new cohorts of early-onset, adult-onset and late-onset/intermediate repeat patients for which, besides accurate AO information, also clinical parameters (MRI scans, liquor markers etc) will be (made) available. This will be used for validation and to fine-tune the molecular landscapes (again using DLA) towards the best prediction of individual patient related clinical markers and AO (WP3). The same models and (most relevant) landscapes will also be used for evaluations of novel mutant protein lowering strategies as will emerge from WP4.This overall development process of landscape prediction is an iterative process that involves (a) data processing (WP5) (b) unsupervised data exploration and dimensionality reduction to find patterns in data and create “labels” for similarity and (c) development of data supervised Deep Learning (DL) models for landscape prediction based on the labels from previous step. Each iteration starts with data that is generated and deployed according to FAIR principles, and the developed deep learning system will be instrumental to connect these WPs. Insights in algorithm sensitivity from the predictive models will form the basis for discussion with field experts on the distinction and phenotypic consequences. While full development of accurate diagnostics might go beyond the timespan of the 5 year project, ideally our final landscapes can be used for new genetic counselling: when somebody is positive for the gene, can we use his/her cells, feed it into the generated cell-based model and better predict the AO and severity? While this will answer questions from clinicians and patient communities, it will also generate new ones, which is why we will study the ethical implications of such improved diagnostics in advance (WP6).
This proposal envisions a solution for organizations and their employees to keep each other resilient and healthy.We aim for proactive detection of stress at an early stage, so it can facilitate a safe and collaborative dialogue between employers and employees at a time that they are both still able to see their co-dependency and mutual interests, while acknowledging the possible tension of conflicting interests. A sorrow shared is a sorrow halved.We use an Impact Plan Approach in which a Theory of Change (the DESTRESS Strategy) directs research activities that identify problems and causse, determine the required change to overcome them, and adjust the DESTRESS strategy to make improvements that are necessary to invoke that change. Subsequently, the DESTRESS strategy will be translated into the DESTRESS solution, for which a strategy for implementation and evaluation will be devised.
