Dementia is often diagnosed after emergency situations have emerged.The social network of elderly was studied in order to find out if persons or institutions could help to discover problems in an earlier phase. It was concluded that family is most important, and that information, rather than detection, is more helpful in the period preceding diagnosis. In: Journal of Clinical Nursing; 19 (1), 89
Rationale: Diagnosis of sarcopenia in older adults is essential for early treatment in clinical practice. Bio-electrical impedance analysis (BIA) may be a valid means to assess appendicular lean mass (ALM) in older adults, but limited evidence is available. Therefore, we aim to evaluate the validity of BIA to assess ALM in older adults.Methods: In 215 community dwelling older adults (age ≥ 55 years), ALM was measured by BIA (Tanita MC-780; 8-points) and compared with dual-energy X-ray absorptiometry (DXA, Hologic Discovery A) as reference. Validity for assessing absolute values of ALM was evaluated by: 1) bias (mean difference), 2) percentage of accurate predictions (within 5% of DXA values), 3) individual error (root mean squared error (RMSE), mean absolute deviation), 4) limits of agreement (Bland-Altman analysis). For diagnosis of low ALM, the lowest quintile of ALM by DXA was used (below 21.4 kg for males and 15.4 for females). Sensitivity and specificity of detecting low ALM by BIA were assessed.Results: Mean age of the subjects was 71.9 ± 6.4, with a BMI of 25.8 ± 4.2 kg/m2, and 70% were females. BIA slightly underestimated ALM compared to DXA with a mean bias of -0.6 ± 0.2 kg. The percentage accurate predictions was 54% with RMSE 1.6 kg and limits of agreements −3.0 to +1.8 kg. Sensitivity was 79%, indicating that 79% of subjects with low ALM according to DXA also had low ALM with the BIA. Specificity was 90%, indicating that 90% of subjects with ‘no low’ ALM according to DXA also had ‘no low’ ALM with the BIA.Conclusions: This comparison showed a poor validity of BIA to assess absolute values of ALM, but a reasonable sensitivity and specificity to diagnose a low level of ALM in community-dwelling older adults in clinical practice.Disclosure of interest: None declared.
Background: The diagnosis of sarcopenia is essential for early treatment of sarcopenia in older adults, for which assessment of appendicular lean mass (ALM) is needed. Multi-frequency bio-electrical impedance analysis (MF-BIA) may be a valid assessment tool to assess ALM in older adults, but the evidences are limited. Therefore, we validated the BIA to diagnose low ALM in older adults.Methods: ALM was assessed by a standing-posture 8 electrode MF-BIA (Tanita MC-780) in 202 community-dwelling older adults (age ≥ 55 years), and compared with dual-energy X-ray absorptiometry (DXA) (Hologic Inc., Marlborough, MA, United States; DXA). The validity for assessing the absolute values of ALM was evaluated by: (1) bias (mean difference), (2) percentage of accurate predictions (within 5% of DXA values), (3) the mean absolute error (MAE), and (4) limits of agreement (Bland-Altman analysis). The lowest quintile of ALM by DXA was used as proxy for low ALM (< 22.8 kg for men, < 16.1 kg for women). Sensitivity and specificity of diagnosing low ALM by BIA were assessed.Results: The mean age of the subjects was 72.1 ± 6.4 years, with a BMI of 25.4 ± 3.6 kg/m2, and 71% were women. BIA slightly underestimated ALM compared to DXA with a mean bias of -0.6 ± 1.2 kg. The percentage of accurate predictions was 54% with a MAE of 1.1 kg, and limits of agreement were -3.0 to + 1.8 kg. The sensitivity for ALM was 80%, indicating that 80% of subjects who were diagnosed as low ALM according to DXA were also diagnosed low ALM by BIA. The specificity was 90%, indicating that 90% of subjects who were diagnosed as normal ALM by DXA were also diagnosed as normal ALM by the BIA.Conclusion: This comparison showed a poor validity of MF-BIA to assess the absolute values of ALM, but a reasonable sensitivity and specificity to recognize the community-dwelling older adults with the lowest muscle mass.
Rotating machinery, such as centrifugal pumps, turbines, bearings, and other critical systems, is the backbone of various industrial processes. Their failures can lead to significant maintenance costs and downtime. To ensure their continuous operation, we propose a fault diagnosis and monitoring framework that leverages the innovative use of acoustic sensors for early fault detection, especially in components less accessible for traditional vibration-based monitoring strategies. The main objective of the proposed project is to develop a fault diagnosis and monitoring framework for rotating machinery, including the fusion of acoustic sensors and physics-based models. By combining real-time monitoring data from acoustic sensors with an understanding of first principles, the framework will enable maintenance practitioners to identify and categorize different failure modes such as wear, fatigue, cavitation, reduced flow, bearing damage, impeller damage, misalignment, etc. In the initial phase, the focus will be on centrifugal pumps using the existing test set-up at the University of Twente. Sorama specializes in acoustic sensors to locate noise sources and will provide acoustic cameras to capture sound patterns related to pump deterioration during various operating conditions. These acoustic signals will then be correlated with the different failure modes and mechanisms that will be described by physics-based models, such as wear, fatigue, cavitation, corrosion, etc. Furthermore, a recently published data set by the Dynamics Based Maintenance research group that includes vibration analysis data and motor current analysis data of various fault scenarios, such as mentioned above, will be used as validation. The anticipated outcome of this project is a versatile framework for a physics-informed acoustic monitoring system. This system is designed to enhance early fault detection significantly, reducing maintenance costs and downtime across a broad spectrum of industrial applications, from centrifugal pumps to turbines, bearings, and beyond.
