In this study we use aggregated weighted scores of environmental effects to study environmental influences on well-being and happiness. To this end, we split a sample of Netherlands Twin Register (NTR) participants into a training (N =4857) and test (N =2077) sample. In the training sample, we use elastic net regression to estimate effect sizes for associations between life satisfaction and two sets of environmental variables: one based on self- report socioenvironmental data, and one based on objective physical environmental data. Based on these effect sizes, we create two poly-environmental scores (PES-S and PES-O, for self-reports and objective data respectively). In the test sample, we perform association analyses between different measures of well-being and the two PESs. We find that the PES-S explains ~36% of the variance in well-being, while the PES-O does not significantly contribute to the model. Variance in other well-being measures (i.e., different life satisfaction domains, subjective happiness, quality of life, flourishing, psychological well-being, self-rated health, depressive problems, and loneliness) are explained to varying extents by the PESs, ranging from 6.36% (self-rated health) to 36.66% (loneliness). These predictive values did not change during the COVID-19 pandemic (N =3214). Validating the PES-S in the UK biobank (N =40,614), we find that the UK biobank PES-S explains about ~12% of the variance in happiness. Lastly, we examine if there is any indication for gene-environment correlation (rGE), the phenomenon where one’s genetic predisposition influences exposure to the environment, by associating the PESs with polygenic scores (PGS) in a sample of Netherlands Twin Register (NTR) and UK Biobank participants. While the PES and PGS were not correlated in the NTR sample, they were correlated in the larger UK biobank sample, indicating the potential presence of rGE. We discuss several limitations pertaining to our dataset, such as a potential influence of common method bias, and reflect on how PESs might be used in future research.
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BackgroundIdentifying modifiable factors associated with well-being is of increased interest for public policy guidance. Developments in record linkage make it possible to identify what contributes to well-being from a myriad of factors. To this end, we link two large-scale data resources; the Geoscience and Health Cohort Consortium, a collection of geo-data, and the Netherlands Twin Register, which holds population-based well-being data.ObjectiveWe perform an Environment-Wide Association Study (EnWAS), where we examine 139 neighbourhood-level environmental exposures in relation to well-being.MethodsFirst, we performed a generalized estimation equation regression (N = 11,975) to test for the effects of environmental exposures on well-being. Second, to account for multicollinearity amongst exposures, we performed principal component regression. Finally, using a genetically informative design, we examined whether environmental exposure is driven by genetic predisposition for well-being.ResultsWe identified 21 environmental factors that were associated with well-being in the domains: housing stock, income, core neighbourhood characteristics, livability, and socioeconomic status. Of these associations, socioeconomic status and safety are indicated as the most important factors to explain differences in well-being. No evidence of gene-environment correlation was found.SignificanceThese observed associations, especially neighbourhood safety, could be informative for policy makers and provide public policy guidance to improve well-being. Our results show that linking databases is a fruitful exercise to identify determinants of mental health that would remain unknown by a more unilateral approach.
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The need for care will increase in the coming years. Most people with a disability or old age receive support from an informal caregiver. Caring for a person with dementia can be difficult because of the BPSD (Behavioral and Psychological Symptoms of Dementia). BPSD, including sleep disturbance, is an important factor for a higher care load. In this scoping review, we aim to investigate whether technology is available to support the informal caregiver, to lower the care burden, improve sleep quality, and therefore influence the reduction of social isolation of informal caregivers of people with dementia. A scoping review is performed following the methodological framework by Arksey and O'Mally and Rumrill et al., the scoping review includes scientific and other sources (unpublished literature, websites, reports, etc.). The findings of the scoping review shows that there are technology applications available to support the informal caregiver of a person with dementia. The technology applications mostly contribute to lower the care burden and/or improve sleep quality and therefore may contribute to reduce social isolation. The technology applications found target either the person with dementia, the informal caregiver, or both.
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