Op 27 januari 2006 is dr. Michiel Scheffer geïnstalleerd als lector Fashion Materials Design bij Saxion in Enschede. Het lectoraat en de bijbehorende kenniskring is gericht op het versterken van de wisselwerking tussen creativiteit, technologie en economie op het gebied van mode en textiel. Deze wisselwerking moet sterker tot uiting komen in het onderwijs en dient ook in samenwerking met het bedrijfsleven tot uiting te komen in een onderzoeksprogramma. Het lectoraat is ondergebracht bij de opleiding Fashion en Textiel Management binnen de Academie voor Kunst en Toegepaste Techniek in Enschede. Dr. Michiel Scheffer is economisch geograaf en is al vijftien jaar actief in de Europese kleding en textielbranche als onderzoeker, consultant en branchemanager. Dit boek bevat de tekst van de lectorale rede van Michiel Scheffer.
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Philanthropy is on the rise in the Dutch visual arts. Fat cash prizes, big-name exhibitions, large-scale renovations, spectacular public artworks, and big scandals are changing the public display of art and undermining the democratic governance of art institutions. While some have critiqued the patron's rise to power, the majority of the art world remains silent, muted by a combination of ignorance and self-censorship. How can we overcome this deadlock and start cultivating a healthy public debate?
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BACKGROUND: Increasing evidence indicates the potential benefits of restricted fluid management in critically ill patients. Evidence lacks on the optimal fluid management strategy for invasively ventilated COVID-19 patients. We hypothesized that the cumulative fluid balance would affect the successful liberation of invasive ventilation in COVID-19 patients with acute respiratory distress syndrome (ARDS).METHODS: We analyzed data from the multicenter observational 'PRactice of VENTilation in COVID-19 patients' study. Patients with confirmed COVID-19 and ARDS who required invasive ventilation during the first 3 months of the international outbreak (March 1, 2020, to June 2020) across 22 hospitals in the Netherlands were included. The primary outcome was successful liberation of invasive ventilation, modeled as a function of day 3 cumulative fluid balance using Cox proportional hazards models, using the crude and the adjusted association. Sensitivity analyses without missing data and modeling ARDS severity were performed.RESULTS: Among 650 patients, three groups were identified. Patients in the higher, intermediate, and lower groups had a median cumulative fluid balance of 1.98 L (1.27-7.72 L), 0.78 L (0.26-1.27 L), and - 0.35 L (- 6.52-0.26 L), respectively. Higher day 3 cumulative fluid balance was significantly associated with a lower probability of successful ventilation liberation (adjusted hazard ratio 0.86, 95% CI 0.77-0.95, P = 0.0047). Sensitivity analyses showed similar results.CONCLUSIONS: In a cohort of invasively ventilated patients with COVID-19 and ARDS, a higher cumulative fluid balance was associated with a longer ventilation duration, indicating that restricted fluid management in these patients may be beneficial. Trial registration Clinicaltrials.gov ( NCT04346342 ); Date of registration: April 15, 2020.
