The world is on the verge of the fourth industrial revolution that will considerably influence society and human life. Today human being is surrounded by technological advancement and every day we face new sophisticated technological systems that affect our daily lives. The business environment is being influenced by Industry 4.0 significantly and a massive transformation in labour market can be observed. The digital economy has become a disruptive factor in several sectors and it has shown a major impact on the logistic industry in terms of workforce transformation. The question that arises is that to what extent the logistic sector is ready for the digital transformation in Industry 4.0 and what factors should be considered by industry players, governments and multi-stakeholders in order to simplify workforce transformation. This study followed a qualitative approach using Grounded Theory to explain the phenomenon of workforce transformation within the logistic sector in Industry 4.0. Furthermore, a literature review was used to explain the role of human resource management in simplification of this process .The findings show that there is a lack of adequate awareness about the impact of the digital transformation on labour. Furthermore, it discusses the role of human resource management as an agent of change in Industry 4.0. The current research presents recommendations for different stakeholders on how to prepare the current and future workforce for the upcoming changes.This study is significant in the sense that it will add to the existing literature and provide practitioners with vital information that can be used to simplify the digital transformation of logistic industry by preparing labor market.
MULTIFILE
Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing. The aim of the present study was to investigate whether physiologically based kinetic (PBK) modeling-facilitated conversion of in vitro toxicity data is an adequate approach to predict in vivo cardiotoxicity in humans. To enable evaluation of predictions made, methadone was selected as the model compound, being a compound for which data on both kinetics and cardiotoxicity in humans are available. A PBK model for methadone in humans was developed and evaluated against available kinetic data presenting an adequate match. Use of the developed PBK model to convert concentration–response curves for the effect of methadone on human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) in the so-called multi electrode array (MEA) assay resulted in predictions for in vivo dose–response curves for methadone-induced cardiotoxicity that matched the available in vivo data. The results also revealed differences in protein plasma binding of methadone to be a potential factor underlying variation between individuals with respect to sensitivity towards the cardiotoxic effects of methadone. The present study provides a proof-of-principle of using PBK modeling-based reverse dosimetry of in vitro data for the prediction of cardiotoxicity in humans, providing a novel testing strategy in cardiac safety studies.
MULTIFILE
Research has pointed out opportunities and research agendas to integrate sustainability issues with supply chain and operations management. However, we find that it is still not mainstream practice to systematically take a sustainability approach in tackling supply chain and operations management issues. In this paper, we make use of behavioral theory to explain the current lack of integration. We conclude through abductive reasoning that the reasons for procrastinating integration of sustainability in supply chain and operations management research are the conflicting nature of the task and the inherent context, which is the focus on operations rather than environmental or social issues.
MULTIFILE
Voor de overgang naar een circulaire economie zijn nieuwe business modellen nodig. Logistiek (levering en retour processen) speelt hierbij een belangrijke rol. Het doel van dit onderzoek is om de ontwikkeling en groei van circulaire business modellen in de logistiek te verkennen en te bepalen.Doel Dit project heeft tot doel inzicht te geven in en handvatten aan te reiken voor de transitie van organisaties naar circulaire business modellen. Vragen die hierbij worden beantwoord zijn o.a.: Welke kansen en bedreigingen biedt een dergelijke transitie? Hoe kunnen principes van de circulaire economie bijdragen aan duurzame waarde proposities? Hoe kunnen organisaties klanten ondersteunen bij product lifecycle management? Resultaten In dit project worden beslissing ondersteunende methode ontwikkeld welke organisaties kunnen gebruiken voor de overgang naar meer circulaire business modellen. Hierbij ligt de focus op de logistieke context en met name het optimaliseren van ketenprocessen (forward & reverse logistics) in relatie tot de interne logistieke processen. Begin april 2022 won het project van KennisDC Logistiek Centre of Expertise de inspiratieprijs voor logistiek parel 2022. Looptijd 01 mei 2020 - 31 maart 2022 Aanpak Het project bestaat uit 4 werkpakketten. Hierbij wordt gekeken naar: aspecten van circulaire business modellen en volwassenheidsniveaus logistieke ketenprocessen logistieke ketenprocessen de interne logistieke processen die nodig zijn voor de afhandeling van retourstromen en afval