Several models in data analysis are estimated by minimizing the objective function defined as the residual sum of squares between the model and the data. A necessary and sufficient condition for the existence of a least squares estimator is that the objective function attains its infimum at a unique point. It is shown that the objective function for Parafac-2 need not attain its infimum, and that of DEDICOM, constrained Parafac-2, and, under a weak assumption, SCA and Dynamals do attain their infimum. Furthermore, the sequence of parameter vectors, generated by an alternating least squares algorithm, converges if it decreases the objective function to its infimum which is attained at one or finitely many points.
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Just what and how eight experienced teachers in four coaching dyads learned during a 1-year reciprocal peer coaching trajectory was examined in the present study. The learning processes were mapped by providing a detailed description of reported learning activities, reported learning outcomes, and the relations between these two. The sequences of learning activities associated with a particular type of learning outcome were next selected, coded, and analyzed using a variety of quantitative methods. The different activity sequences undertaken by the teachers during a reciprocal peer coaching trajectory were found to trigger different aspects of their professional development.
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To obtain large-scale sequence alignments in a fast and flexible way is an important step in the analyses of next generation sequencing data. Applications based on the Smith-Waterman (SW) algorithm are often either not fast enough, limited to dedicated tasks or not sufficiently accurate due to statistical issues. Current SW implementations that run on graphics hardware do not report the alignment details necessary for further analysis.
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In line with the ‘Natuur- en milieubeleidsplan Caribisch Nederland 2020-2030 (NMBP)’ the consortium intends with this research proposal to contribute to a prosperous society with a resilient population and healthy natural environment. The Caribbean Netherlands are dealing with a situation where imported vegetables and fruits are mostly imported and hardly affordable. This leads to consuming unhealthy food and high obesities rates as a consequence. A lack of good agricultural practices with regard to water-smart and nature inclusive agriculture, as well as limited coping capacities to deal with hazards and climate change, results in very limited local production and interest. Initiatives that focused only on agrotechnological solutions for food resilient futures turned out to be ineffective due to a lack of local ownership, which jeopardizes sustainability. Moreover, the ‘green’ and ‘blue’ domains are not seen as attractive career perspectives among youth, hampering a bright future for those domains. The aim of this research is to contribute to water-smart and nature inclusive food resilience embedded in a local participatory perspective in the Caribbean Netherlands. To address the above challenges, a living lab approach is adopted, where youth will be trained as (co)-facilitators (WP1) who will contribute to a participatory envisioning process and an articulation of food resilient futures (WP2). Finally, based on the envisioning process local stakeholders will select and implement experiments for food resilient futures followed by dissemination of results among key stakeholders as well as children and youth at the BES islands (WP3). This project strategy will lead to a network of a living lab where professionals and youth work together on food resilient futures. Training manuals and the results of experiments with regard to water and food system alternatives will be used actively to encourage youth to be involved in sustainable agriculture and consumption.
INXCES will use and enhance innovative 3D terrain analysis and visualization technology coupled with state-of-the-art satellite remote sensing to develop cost-effective risk assessment tools for urban flooding, aquifer recharge, ground stability and subsidence. INXCES will develop quick scan tools that will help decision makers and other actors to improve the understanding of urban and peri-urban terrains and identify options for cost effective implementation of water management solutions that reduce the negative impacts of extreme events, maximize beneficial uses of rainwater and stormwater for small to intermediate events and provide long-term resilience in light of future climate changes. The INXCES approach optimizes the multiple benefits of urban ecosystems, thereby stimulating widespread implementation of nature-based solutions on the urban catchment scale.INXCES will develop new innovative technological methods for risk assessment and mitigation of extreme hydroclimatic events and optimization of urban water-dependent ecosystem services at the catchment level, for a spectrum of rainfall events. It is widely acknowledged that extreme events such as floods and droughts are an increasing challenge, particularly in urban areas. The frequency and intensity of floods and droughts pose challenges for economic and social development, negatively affecting the quality of life of urban populations. Prevention and mitigation of the consequences of hydroclimatic extreme events are dependent on the time scale. Floods are typically a consequence of intense rainfall events with short duration. In relation to prolonged droughts however, a much slower timescale needs to be considered, connected to groundwater level reductions, desiccation and negative consequences for growing conditions and potential ground – and building stability.INXCES will take a holistic spatial and temporal approach to the urban water balance at a catchment scale and perform technical-scientific research to assess, mitigate and build resilience in cities against extreme hydroclimatic events with nature-based solutions.INXCES will use and enhance innovative 3D terrain analysis and visualization technology coupled with state-of-the-art satellite remote sensing to develop cost-effective risk assessment tools for urban flooding, aquifer recharge, ground stability and subsidence. INXCES will develop quick scan tools that will help decision makers and other actors to improve the understanding of urban and peri-urban terrains and identify options for cost effective implementation of water management solutions that reduce the negative impacts of extreme events, maximize beneficial uses of rainwater and stormwater for small to intermediate events and provide long-term resilience in light of future climate changes. The INXCES approach optimizes the multiple benefits of urban ecosystems, thereby stimulating widespread implementation of nature-based solutions on the urban catchment scale.
Routine neuropathology diagnostic methods are limited to histological staining techniques or directed PCR for pathogen detection and microbial cultures of brain abscesses are negative in one-third of the cases. Fortunately, due to improvements in technology, metagenomic sequencing of a conserved bacterial gene could provide an alternative diagnostic method. For histopathological work up, formalin-fixed paraffin-embedded (FFPE) tissue with highly degraded nucleic acids is the only material being available. Innovative amplicon-specific next-generation sequencing (NGS) technology has the capability to identify pathogens based on the degraded DNA within a few hours. This approach significantly accelerates diagnostics and is particularly valuable to identify challenging pathogens. This ensures optimal treatment for the patient, minimizing unnecessary health damage. Within this project, highly conserved primers in a universal PCR will be used, followed by determining the nucleotide sequence. Based on the obtained data, it is then precisely determined which microorganism(s) is/are responsible for the infection, even in cases of co-infection with multiple pathogens. This project will focus to answer the following research question; how can a new form of rapid molecular diagnostics contribute to the identification of microbial pathogens in CNS infections? The SME partner Molecular Biology Systems B.V. (MBS) develops and sells equipment for extremely rapid execution of the commonly used PCR. In this project, the lectorate Analysis Techniques in the Life Sciences (Avans) will, in collaboration with MBS, Westerdijk Institute (WI-KNAW) and the Institute of Neuropathology (Münster, DE) establish a new molecular approach for fast diagnosis within CNS infections using this MBS technology. This enables the monitoring of infectious diseases in a fast and user-friendly manner, resulting in an improved treatment plan.