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Ethiek en chatbots

Chatbots zijn handige tools om klantencontacten efficiënt af te handelen. De inzet van chatbottechnologie roept wel ethische vragen op. Aan de hand van een krantenartikel over het callcenter van het onlinewarenhuis Wehkamp verkent filosoof en bedrijfskundige Henriëtta Joosten een aantal morele kwesties.

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Talent 2.0 Wie het kanaal heeft, heeft de macht

1e alinea column: Oproep aan de Dutch Cowboys Talenten om de werkelijke maatschappelijke uitdagingen te blijven benoemen, deze agenda te occupy'en en concrete bijdragen te formuleren als ode aan de nieuwe wereld met zijn vele nieuwe mogelijkheden! Hans Keilson overleed in mei 2011. Het kan gek lopen en ik gebruik Hans Keilson even als metafoor. Nog geen twee jaar geleden was een kort artikel in de New York Times genoeg om deze schrijver en psychiater te herontdekken en opnieuw te agenderen in Nederland nadat er pakweg 60 jaar niets met zijn boeken gebeurd was. De complete schrijvers- en uitgever scene had hem gedurende 60 jaar 'even gemist'. Nederlandse media hadden de euvele moed te spreken van een 'late doorbraak'. Eén zin in de NYT was genoeg om het circus in beweging te zetten.

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Fashion consumer behaviour impact on the model of last mile urban area emissions

To enhance the validity of a mobility emission-effects model, a research is conducted on consumer behaviour. Consumer mobilitypreferences are the main determining factor in the proposed model that describes the kilometre and emission outcome under several scenarios. Motorized mobility of consumers buying fashion in shopping areas cause more kilometres in the network and subsequently more emission than when the fashion is bought online and the delivery is done by the parcel delivery services.The model provides an indication of best practice: if consumers change their shopping preferences they reduce emission and they also enable the PDSs to optimize their delivery operations

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Fashion consumer behaviour impact on the model of last mile urban area emissions

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Scenario rapport Binnenstad Leeuwarden

In dit rapport worden 4 toekomstscenario's geschetst voor de ontwikkeling van de binnenstad van Leeuwarden.

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From XXS to XXL: Towards a typology of distribution centre facilities

Distribution centres are becoming more and more relevant for spatial planning, due to their rapidly increasing size and number. There is little literature, however, that provides a generalized analysis of the size and functional attributes of distribution centres, and none that discusses the relationships between these attributes. Our aim is to fill this gap by providing new evidence and analysis to understand this relationship. We make use of an extensive database of 2888 DCs in the Netherlands to develop a new typology of DCs based on the geographical location of DCs, their functional attributes and client sector characteristics. The analysis shows that the context in which medium sized DCs are operating is more heterogeneous than in the case of very large and small size DCs. This study is a first attempt to analyse this relationship between facility size and functions based on a rich and extensive dataset of large population of DCs. The results can serve as input for further quantitative statistical analysis and international comparison.

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From XXS to XXL: Towards a typology of distribution centre facilities

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Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model

From teh UU repository: "Background: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and long-term efficacy. The use of non-digestible oligosaccharides might improve OIT efficacy since they are known to directly modulate intestinal epithelial and immune cells in addition to acting as prebiotics. Aim: To investigate whether a diet supplemented with plant-derived fructo-oligosaccharides (FOS) supports the efficacy of OIT in a murine cow's milk allergy model and to elucidate the potential mechanisms involved. Methods: After oral sensitization to the cow's milk protein whey, female C3H/HeOuJ mice were fed either a control diet or a diet supplemented with FOS (1% w/w) and received OIT (10 mg whey) 5 days a week for 3 weeks by gavage. Intradermal (i.d.) and intragastric (i.g.) challenges were performed to measure acute allergic symptoms and mast cell degranulation. Blood and organs were collected to measure antibody levels and T cell and dendritic cell populations. Spleen-derived T cell fractions (whole spleen-and CD25-depleted) were transferred to naive recipient mice to confirm the involvement of regulatory T cells (Tregs) in allergy protection induced by OIT + FOS. Results: OIT + FOS decreased acute allergic symptoms and mast cell degranulation upon challenge and prevented the challenge-induced increase in whey-specific IgE as observed in sensitized mice. Early induction of Tregs in the mesenteric lymph nodes (MLN) of OIT + FOS mice coincided with reduced T cell responsiveness in splenocyte cultures. CD25 depletion in OIT + FOS-derived splenocyte suspensions prior to transfer abolished protection against signs of anaphylaxis in recipients. OIT + FOS increased serum galectin-9 levels. No differences in short-chain fatty acid (SCFA) levels in the cecum were observed between the treatment groups. Concisely, FOS supplementation significantly improved OIT in the acute allergic skin response, %Foxp3+ Tregs and %LAP+ Th3 cells in MLN, and serum galectin-9 levels. Conclusion: FOS supplementation improved the efficacy of OIT in cow's milk allergic mice. Increased levels of Tregs in the MLN and abolished protection against signs of anaphylaxis upon transfer of CD25-depleted cell fractions, suggest a role for Foxp3+ Tregs in the protective effect of OIT + FOS. "

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The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models

From Pubmed: " BACKGROUND: Antigen-specific immunotherapy (AIT) is a promising therapeutic approach for both cow's milk allergy (CMA) and peanut allergy (PNA), but needs optimization in terms of efficacy and safety. AIM: Compare oral immunotherapy (OIT) and subcutaneous immunotherapy (SCIT) in murine models for CMA and PNA and determine the dose of allergen needed to effectively modify parameters of allergy. METHODS: Female C3H/HeOuJ mice were sensitized intragastrically (i.g.) to whey or peanut extract with cholera toxin. Mice were treated orally (5 times/week) or subcutaneously (3 times/week) for three consecutive weeks. Hereafter, the acute allergic skin response, anaphylactic shock symptoms and body temperature were measured upon intradermal (i.d.) and intraperitoneal (i.p.) challenge, and mast cell degranulation was measured upon i.g. challenge. Allergen-specific IgE, IgG1 and IgG2a were measured in serum at different time points. Single cell suspensions derived from lymph organs were stimulated with allergen to induce cytokine production and T cell phenotypes were assessed using flow cytometry. RESULTS: Both OIT and SCIT decreased clinically related signs upon challenge in the CMA and PNA model. Interestingly, a rise in allergen-specific IgE was observed during immunotherapy, hereafter, treated mice were protected against the increase in IgE caused by allergen challenge. Allergen-specific IgG1 and IgG2a increased due to both types of AIT. In the CMA model, SCIT and OIT reduced the percentage of activated Th2 cells and increased the percentage of activated Th1 cells in the spleen. OIT increased the percentage of regulatory T cells (Tregs) and activated Th2 cells in the MLN. Th2 cytokines IL-5, IL-13 and IL-10 were reduced after OIT, but not after SCIT. In the PNA model, no differences were observed in percentages of T cell subsets. SCIT induced Th2 cytokines IL-5 and IL-10, whereas OIT had no effect. CONCLUSION: We have shown clinical protection against allergic manifestations after OIT and SCIT in a CMA and PNA model. Although similar allergen-specific antibody patterns were observed, differences in T cell and cytokine responses were shown. Whether these findings are related to a different mechanism of AIT in CMA and PNA needs to be elucidated."

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The effect of endurance exercise on intestinal integrity in well‐trained healthy men

Exercise is one of the external factors associated with impairment of intestinal integrity, possibly leading to increased permeability and altered absorption. Here, we aimed to examine to what extent endurance exercise in the glycogen‐depleted state can affect intestinal permeability toward small molecules and protein‐derived peptides in relation to markers of intestinal function. Eleven well‐trained male volunteers (27 ± 4 years) ingested 40 g of casein protein and a lactulose/rhamnose (L/R) solution after an overnight fast in resting conditions (control) and after completing a dual – glycogen depletion and endurance – exercise protocol (first protocol execution). The entire procedure was repeated 1 week later (second protocol execution). Intestinal permeability was measured as L/R ratio in 5 h urine and 1 h plasma. Five‐hour urine excretion of betacasomorphin‐7 (BCM7), postprandial plasma amino acid levels, plasma fatty acid binding protein 2 (FABP‐2), serum pre‐haptoglobin 2 (preHP2), plasma glucagon‐like peptide 2 (GLP2), serum calprotectin, and dipeptidylpeptidase‐4 (DPP4) activity were studied as markers for excretion, intestinal functioning and recovery, inflammation, and BCM7 breakdown activity, respectively. BCM7 levels in urine were increased following the dual exercise protocol, in the first as well as the second protocol execution, whereas 1 h‐plasma L/R ratio was increased only following the first exercise protocol execution. FABP2, preHP2, and GLP2 were not changed after exercise, whereas calprotectin increased. Plasma citrulline levels following casein ingestion (iAUC) did not increase after exercise, as opposed to resting conditions. Endurance exercise in the glycogen depleted state resulted in a clear increase of BCM7 accumulation in urine, independent of DPP4 activity and intestinal permeability. Therefore, strenuous exercise could have an effect on the amount of food‐derived bioactive peptides crossing the epithelial barrier. The health consequence of increased passage needs more in depth studies.

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The effect of endurance exercise on intestinal integrity in well‐trained healthy men

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Multicultureel competent samen(-)leven

De Nederlandse samenleving is multicultureel met burgers, die afkomstig zijn uit meerdere werelddelen. In Deze openbare les zullen wij grondig naar hun onderlinge omgangsvormen kijken. Meer specifiek ga ik zowel in op de vraag of men elkaar als medeburger accepteert als op de vraag hoe wit en zwart tegen elkaar aankijken. Ik maak duidelijk dat diverse blokkades die de onderlinge omgang belemmeren, niet herkend of onderkend worden. Mijn vertrekpunt is dat te verbeteren. Multiculturele competentie vraagt dan wel een visie waarin niet alleen burgers, maar ook etnische groepen gelijkwaardig zijn. Met behulp van zo’n visie kan gezocht worden naar de juiste toon in het multiculturele debat en naar de juiste aanpak van multiculturele vraagstukken. Multiculturele competentie kan dan relaties versoepelen en onderlinge goodwill bevorderen, waardoor de kans op succesvol of resultaatgericht handelen groter wordt. Dit is van groot belang voor de werkvelden waarvoor Hogeschool De Horst haar professionals opleidt. Vanuit dit gezichtspunt wil het lectoraat ‘Diversiteit en de multiculturele competentie’ educatieve activiteiten ontwikkelen om multiculturele competentie te bevorderen. Dit doen wij niet door in leersituaties hapklare brokken te serveren of standaardrecepten aan te reiken, maar wel door vanuit onze visie, in dialoog met deelnemers, te zoeken naar aanknopingspunten en richtlijnen voor multiculturele competentie. Bij competentie spelen altijd de concrete situatie, kennis-, vaardigheden- en houdingsdimensies een rol (Cluitmans, 2002).

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Producten 9

Ethiek en chatbots

Talent 2.0 Wie het kanaal heeft, heeft de macht

Fashion consumer behaviour impact on the model of last mile urban area emissions

Scenario rapport Binnenstad Leeuwarden

From XXS to XXL: Towards a typology of distribution centre facilities

Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model

The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models

The effect of endurance exercise on intestinal integrity in well‐trained healthy men

Multicultureel competent samen(-)leven

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Producten 9

Ethiek en chatbots

Talent 2.0 Wie het kanaal heeft, heeft de macht

Fashion consumer behaviour impact on the model of last mile urban area emissions

Scenario rapport Binnenstad Leeuwarden

From XXS to XXL: Towards a typology of distribution centre facilities

Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model

The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models

The effect of endurance exercise on intestinal integrity in well‐trained healthy men

Multicultureel competent samen(-)leven