Abstract: Hypertension is both a health problem and a financial one globally. It affects nearly 30 % of the general population. Elderly people, aged ≥65 years, are a special group of hypertensive patients. In this group, the overall prevalence of the disease reaches 60 %, rising to 70 % in those aged ≥80 years. In the elderly population, isolated systolic hypertension is quite common. High systolic blood pressure is associated with an increased risk of cardiovascular disease, cerebrovascular disease, peripheral artery disease, cognitive impairment and kidney disease. Considering the physiological changes resulting from ageing alongside multiple comorbidities, treatment of hypertension in elderly patients poses a significant challenge to treatment teams. Progressive disability with regard to the activities of daily life, more frequent hospitalisations and low quality of life are often seen in elderly patients. There is discussion in the literature regarding frailty syndrome associated with old age. Frailty is understood to involve decreased resistance to stressors, depleted adaptive and physiological reserves of a number of organs, endocrine dysregulation and immune dysfunction. The primary dilemma concerning frailty is whether it should only be defined on the basis of physical factors, or whether psychological and social factors should also be included. Proper nutrition and motor rehabilitation should be prioritised in care for frail patients. The risk of orthostatic hypotension is a significant issue in elderly patients. It results from an autonomic nervous system dysfunction and involves maladjustment of the cardiovascular system to sudden changes in the position of the body. Other significant issues in elderly patients include polypharmacy, increased risk of falls and cognitive impairment. Chronic diseases, including hypertension, deteriorate baroreceptor function and result in irreversible changes in cerebral and coronary circulation. Concurrent frailty or other components of geriatric syndrome in elderly patients are associated with a worse perception of health, an increased number of comorbidities and social isolation of the patient. It may also interfere with treatment adherence. Identifying causes of non-adherence to pharmaceutical treatment is a key factor in planning therapeutic interventions aimed at increasing control, preventing complications, and improving long-term outcomes and any adverse effects of treatment. Diagnosis of frailty and awareness of the associated difficulties in adhering to treatment may allow targeting of those elderly patients who have a poorer prognosis or may be at risk of complications from untreated or undertreated hypertension, and for the planning of interventions to improve hypertension control.
Current global trends show that different regions of the globe face an increased level of urbanization, and there is a swift aging process from the Western to the Eastern European countries. Romania is a typical country expecting to triple the percentage of the older population aged 65 and over in the next 30 years. Urban policies often neglect such demographic perspectives. The World Health Organization launched the age-friendly city and communities' movement that proposes solutions for older people to age actively by improving their welfare and social participation. The concept of an age-friendly city comprised eight dimensions: (1) outdoor spaces and buildings; (2) transportation; (3) housing; (4) social participation; (5) respect and social inclusion; (6) civic participation and employment; (7) communication and information; and (8) community support and health services. It raises some important questions about how to measure and evaluate urban policies in this framework. Current work presents the process of adaptation and validation for the Romanian older population of a standardized tool - the Age-Friendly Cities and Communities Questionnaire (AFCCQ). The validation study was conducted in Bucharest (n = 424) on a representative sample of older people, who were asked to rate their life in the city, following the eight dimensions and an additional one regarding their financial situation. Four clusters were differentiated in the analysis, resulting in different views of older adults on their experience of living in the city, showing that people's socio-economic status, their living arrangements and health situation play a role in shaping their views on city life. The results highlight the importance of standardized tools to design urban policies following an age-friendly agenda.
MULTIFILE
In this study, growth trajectories (from admission until unconditional release) of crime-related dynamic risk factors were investigated in a sample of Dutch forensic patients (N = 317), using latent growth curve modeling. After testing the unconditional model, three predictors were added: first-time offender versus recidivist, age, and treatment duration. Postanalyses were chi-square difference tests, t tests, and analyses of variance (ANOVAs) to assess differences in trajectories. Overall, on scale level, a decrease of risk factors over time was found. The predictors showed no significant slope differences although age and treatment duration differed significantly at some time points. The oldest age group performed worse, especially at later time points. Treatment duration effects were found at the second time point. Our results that forensic patients show a decrease in crime-related risk factors may indicate that treatment is effective. This study also found differences in growth rates, indicating the effect of individual differences
Due to societal developments, like the introduction of the ‘civil society’, policy stimulating longer living at home and the separation of housing and care, the housing situation of older citizens is a relevant and pressing issue for housing-, governance- and care organizations. The current situation of living with care already benefits from technological advancement. The wide application of technology especially in care homes brings the emergence of a new source of information that becomes invaluable in order to understand how the smart urban environment affects the health of older people. The goal of this proposal is to develop an approach for designing smart neighborhoods, in order to assist and engage older adults living there. This approach will be applied to a neighborhood in Aalst-Waalre which will be developed into a living lab. The research will involve: (1) Insight into social-spatial factors underlying a smart neighborhood; (2) Identifying governance and organizational context; (3) Identifying needs and preferences of the (future) inhabitant; (4) Matching needs & preferences to potential socio-techno-spatial solutions. A mixed methods approach fusing quantitative and qualitative methods towards understanding the impacts of smart environment will be investigated. After 12 months, employing several concepts of urban computing, such as pattern recognition and predictive modelling , using the focus groups from the different organizations as well as primary end-users, and exploring how physiological data can be embedded in data-driven strategies for the enhancement of active ageing in this neighborhood will result in design solutions and strategies for a more care-friendly neighborhood.
In het project “ADVICE: Advanced Driver Vehicle Interface in a Complex Environment” zijn belangrijke onderzoeksresultaten geboekt op het gebied van het schatten van de toestand en werklast van een voertuigbestuurder om hiermee systemen die informatie geven aan de bestuurder adaptief te maken om zo de veiligheid te verhogen. Een voorbeeld is om minder belangrijke informatie van een navigatiesysteem te onderdrukken, zolang de bestuurder een hoge werklast ervaart voor het autorijden en/of belangrijke informatie juist duidelijker weer te geven. Dit leidt tot een real-time werklast schatter die geografische informatie meeneemt, geavaleerd in zowel een rijsimulator als op de weg. In de ontwikkeling naar automatisch rijden is de veranderende rol van de bestuurder een belangrijk (veiligheids) onderwerp, welke sterk gerelateerd is aan de werklast van de bestuurder. Indien rijtaken meer geautomatiseerd worden, wijzigt de rol van actieve bestuurder meer naar supervisie van de rijtaken, maar tevens met de eis om snel en gericht in te grijpen indien de situatie dit vereist. Zowel deze supervisie als interventietaak zijn geen eenvoudige taken met onderling een sterk verschillende werklast (respectievelijk lage en (zeer) hoge werklast). Of een goede combinatie inclusief snelle overgangen tussen deze twee hoofdtaken veilig mogelijk is voor een bestuurder en hoe dit dan het beste ondersteund kan worden, is een belangrijk onderwerp van huidig onderzoek. De ontwikkeling naar autonoom rijden verandert niet alleen de rol van de bestuurder, maar zal ook de eisen aan het rijgedrag van het voertuig beïnvloeden, de voertuigdynamica. Voor de actieve bestuurder kunnen snelle voertuigreacties op bestuurdersinput belangrijk zijn, zeker voor een ‘sportief’ rijdende bestuurder. Indien dit voertuig ook automatische rijtaken moet uitvoeren, kan juist een meer gelijkmatig rijgedrag gewenst zijn, zodat de bestuurder ook andere taken kan uitvoeren. Dit stelt eisen aan vertaling van (automatische) input naar voertuigreactie en aan de voertuigdynamica. Mogelijk wil zelfs een sportieve bestuurder een meer comfortabel voertuiggedrag tijdens automatisch rijden. Eveneens voor deze twee voertuigtoestanden, menselijke of automatische besturing, moet gezocht worden naar een goede combinatie inclusief (veilige) overgangen tussen deze twee toestanden. Hierbij speelt de werklast en toestand van de bestuurder een doorslaggevende rol. In de geschetste ontwikkelingen in automatisch rijden kunnen de onderzoeksresultaten van ADVICE een goede ondersteuning bieden. Veel van deze ontwikkelingen worstelen met het schatten van de werklast van de bestuurder als cruciaal (veiligheids) aspect van automatisch rijden. De ADVICE resultaten zijn echter gepresenteerd voor beperkt publiek en gepubliceerd op conferenties, waarvan de artikelen veelal slechts tegen betaling toegankelijk zijn. Daarnaast zijn dergelijke artikelen gelimiteerd in aantal pagina’s waardoor de over te dragen informatie beperkt is. Om een betere doorwerking van ADVICE aan ‘iedereen’ te realiseren en tevens de mogelijkheden hiervan in de toekomst van automatisch rijden te plaatsen, willen wij top-up gebruiken om hierover een artikel te schrijven en dit in een peer-reviewed Open Access tijdschrift online toegankelijk te maken. Hierdoor wordt de informatie voor iedereen, gratis toegankelijk (open access), is de inhoud uitgebreider aan te geven (tijdschriftartikel) en is de inhoud en kwaliteit goed en relevant voor het vakgebied (peer-reviewed).
The anterior cruciate ligament (ACL) is a strong rope-like tissue which connects the femur to the tibia in the knee joint. Its function is to provide structural stability to the knee while preventing unnatural forward movement of the tibia relative to the femur. Acute complete ACL ruptures during movements like knee hyperextension or sudden changes of direction (pivoting) damage two entities: the ligament itself and its nerve connections to the posterior tibial nerve (PTN). PTN innervation in the ACL is essential for: a) proprioception (e.g. perception of position and movement/acceleration experienced by the ligament), and b) stability of the knee joint. Upon ACL rupture, the orthopedic surgeon reconstructs the ACL with a graft from the hamstring, patellar or quadriceps tendon. After the surgery, the goal is to regain neuromuscular control and dynamic stabilization during rehabilitation as soon as possible for a quick return to sports and daily activities. However, surgeons are not able to reconstruct the nerve gap between the PTN and the grafted ligament due to the microscopic size of the innervation in the ACL. Not linking the PTN to the graft creates a disconnection between the knee joint and the spinal cord. To mitigate these disadvantages in ACL surgery, this study focuses on activating the growth of proprioception nerve endings using a ligament loaded with growth factors (neurotrophins). We hypothesize that neurotrophins will activate proprioceptive fibers of neurons close to the ACL. We describe graft fabrication steps and in vitro experiments to expand on the regeneration capacity of a commercially available ACL-like synthetic ligament called LARS. The results will bring the ACL regeneration field closer to having a graft that can aid patients in regaining mobility and stability during locomotion and running, confidence in the strength of the knee joint, and quick return to sports.
