IL22 is an important cytokine involved in the intestinal defense mechanisms against microbiome. By using ileum-derived organoids, we show that the expression of anti-microbial peptides (AMPs) and anti-viral peptides (AVPs) can be induced by IL22. In addition, we identified a bacterial and a viral route, both leading to IL22 production by T cells, but via different pathways. Bacterial products, such as LPS, induce enterocyte-secreted SAA1, which triggers the secretion of IL6 in fibroblasts, and subsequently IL22 in T cells. This IL22 induction can then be enhanced by macrophage-derived TNFα in two ways: by enhancing the responsiveness of T cells to IL6 and by increasing the expression of IL6 by fibroblasts. Viral infections of intestinal cells induce IFNβ1 and subsequently IL7. IFNβ1 can induce the expression of IL6 in fibroblasts and the combined activity of IL6 and IL7 can then induce IL22 expression in T cells. We also show that IL22 reduces the expression of viral entry receptors (e.g. ACE2, TMPRSS2, DPP4, CD46 and TNFRSF14), increases the expression of anti-viral proteins (e.g. RSAD2, AOS, ISG20 and Mx1) and, consequently, reduces the viral infection of neighboring cells. Overall, our data indicates that IL22 contributes to the innate responses against both bacteria and viruses.
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• Our research suggest that anthocyanins are promising anti-bacterial agents • The antimicrobial effects are highly dependent on the source of the anthocyanin-extract • Rose-anthocyanins appear to posses the strongest anti-bacterial effects • Gram-positive strains appear to be more sensitive compared to gram-negative strains • Future research efforts should focus on different anthocyanin entities
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Justice for nature remains a confused term. In recent decades justice has predominantly been limited to humanity, with a strong focus on social justice, and its spin-off – environmental justice for people. We first examine the formal rationale for ecocentrism and ecological ethics, as this underpins attitudes towards justice for nature, and show how justice for nature has been affected by concerns about dualisms and by strong anthro-pocentric bias. We next consider the traditional meaning of social justice, alongside the recent move by some scholars to push justice for nature into social justice, effectively weakening any move to place ecojustice centre-stage. This, we argue, is both unethical and doomed to failure as a strategy to protect life on Earth. The dominant meaning of ‘environmental justice’ – in essence, justice for humans in regard to environmental issues – is also explored. We next discuss what ecological justice (ecojustice) is, and how academia has ignored it for many decades. The charge of ecojustice being ‘antihuman’ is refuted. We argue that distributive justice can also apply to nature, including an ethic of bio-proportionality, and also consider how to reconcile social justice and eco-justice, arguing that ecojustice must now be foregrounded to ensure effective conservation. After suggesting a ‘Framework for implementing ecojustice’ for conservation practitioners, we conclude by urging academia to foreground ecojustice. https://doi.org/10.1016/j.biocon.2018.09.011 LinkedIn: https://www.linkedin.com/in/helenkopnina/
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