The design of a spatial distribution structure is of strategic importance for companies, to meet required customer service levels and to keep logistics costs as low as possible. Spatial distribution structure decisions concern distribution channel layout – i.e. the spatial layout of the transport and storage system – as well as distribution centre location(s). This paper examines the importance of seven main factors and 33 sub-factors that determine these decisions. The Best-Worst Method (BWM) was used to identify the factor weights, with pairwise comparison data being collected through a survey. The results indicate that the main factor is logistics costs. Logistics experts and decision makers respectively identify customer demand and service level as second most important factor. Important sub-factors are demand volatility, delivery time and perishability. This is the first study that quantifies the weights of the factors behind spatial distribution structure decisions. The factors and weights facilitate managerial decision-making with regard to spatial distribution structures for companies that ship a broad range of products with different characteristics. Public policy-makers can use the results to support the development of land use plans that provide facilities and services for a mix of industries.
IntroductionThe driving pressure (ΔP) has an independent association with outcome in patients with acute respiratory distress syndrome (ARDS). INTELLiVENT-Adaptive Support Ventilation (ASV) is a closed-loop mode of ventilation that targets the lowest work and force of breathing.AimTo compare transpulmonary and respiratory system ΔP between closed-loop ventilation and conventional pressure controlled ventilation in patients with moderate-to-severe ARDS.MethodsSingle-center randomized cross-over clinical trial in patients in the early phase of ARDS. Patients were randomly assigned to start with a 4-h period of closed-loop ventilation or conventional ventilation, after which the alternate ventilation mode was selected. The primary outcome was the transpulmonary ΔP; secondary outcomes included respiratory system ΔP, and other key parameters of ventilation.ResultsThirteen patients were included, and all had fully analyzable data sets. Compared to conventional ventilation, with closed-loop ventilation the median transpulmonary ΔP with was lower (7.0 [5.0–10.0] vs. 10.0 [8.0–11.0] cmH2O, mean difference − 2.5 [95% CI − 2.6 to − 2.1] cmH2O; P = 0.0001). Inspiratory transpulmonary pressure and the respiratory rate were also lower. Tidal volume, however, was higher with closed-loop ventilation, but stayed below generally accepted safety cutoffs in the majority of patients.ConclusionsIn this small physiological study, when compared to conventional pressure controlled ventilation INTELLiVENT-ASV reduced the transpulmonary ΔP in patients in the early phase of moderate-to-severe ARDS. This closed-loop ventilation mode also led to a lower inspiratory transpulmonary pressure and a lower respiratory rate, thereby reducing the intensity of ventilation.Trial registration Clinicaltrials.gov, NCT03211494, July 7, 2017. https://clinicaltrials.gov/ct2/show/NCT03211494?term=airdrop&draw=2&rank=1.
MULTIFILE
The main stream literature on social justice and European integration distinguishes between three models of providing social justice in Europe: the family, the market and the state. Markets have demonstrated their limitations in the current economic crises, and New Public Management quickly disappears behind the horizon. The Welfare State appealed to many and was a main driver of European integration, but its fiscal implications and its normative bias toward social engineering render it practically impossible. The family does well, these days, as a coping model, but individualization is widespread and this makes it impossible to view the family as a prime base for social justice in the European Union in the decades. So, where do we turn.
MULTIFILE
Hotelschool The Hague (HTH) was founded and funded in 1929 by the hospitality industry to create a hub where industry partners could gain and share new insights, skills and knowledge. Since then, it has become a professional operation with a solid international reputation in hospitality management. Though HTH has expanded considerably over the years, it has always remained true to its original mandate with a clear commitment to hospitality and a strong connection with the industry. Since its establishment, HTH has sharpened its focus, remaining regionally rooted with an increasingly concentrated international outlook. In line with its heritage, HTH established an ambitious research and internationalisation strategy through its Research Center in 2010 and has pursued that strategy ever since. The goals of the strategy are clear: to achieve international recognition for high quality research that has immediate practical application in the real world while driving towards sustainable development facilitated by an expansive international network and learning community. In pursuit of this ambition, HTH finds the perfect opportunity in this Pilot Richting Europa project to advance the progress made in its established research and internationalisation strategy and to focus the expansion of its international network towards industrial, governmental, and other private and public sector partners. Through this project, it is the ambition of HTH to increase the impact of its research area, City Hospitality. City Hospitality is mainly a nationally focussed initiative which would significantly benefit from international exchange with other European cities engaging in hospitality efforts. This will be achieved through (1) the expansion of its network of industrial and governmental partners and networks across Europe and (2) by increasing its participation in cooperative European projects, with the ultimate aim of leading a consortium for a European project by the end of the project year.
