Background: Advanced statistical modeling techniques may help predict health outcomes. However, it is not the case that these modeling techniques always outperform traditional techniques such as regression techniques. In this study, external validation was carried out for five modeling strategies for the prediction of the disability of community-dwelling older people in the Netherlands. Methods: We analyzed data from five studies consisting of community-dwelling older people in the Netherlands. For the prediction of the total disability score as measured with the Groningen Activity Restriction Scale (GARS), we used fourteen predictors as measured with the Tilburg Frailty Indicator (TFI). Both the TFI and the GARS are self-report questionnaires. For the modeling, five statistical modeling techniques were evaluated: general linear model (GLM), support vector machine (SVM), neural net (NN), recursive partitioning (RP), and random forest (RF). Each model was developed on one of the five data sets and then applied to each of the four remaining data sets. We assessed the performance of the models with calibration characteristics, the correlation coefficient, and the root of the mean squared error. Results: The models GLM, SVM, RP, and RF showed satisfactory performance characteristics when validated on the validation data sets. All models showed poor performance characteristics for the deviating data set both for development and validation due to the deviating baseline characteristics compared to those of the other data sets. Conclusion: The performance of four models (GLM, SVM, RP, RF) on the development data sets was satisfactory. This was also the case for the validation data sets, except when these models were developed on the deviating data set. The NN models showed a much worse performance on the validation data sets than on the development data sets.
DOCUMENT
INTRODUCTION: In patients with cancer, low muscle mass has been associated with a higher risk of fatigue, poorer treatment outcomes, and mortality. To determine body composition with computed tomography (CT), measuring the muscle quantity at the level of lumbar 3 (L3) is suggested. However, in patients with cancer, CT imaging of the L3 level is not always available. Thus far, little is known about the extent to which other vertebra levels could be useful for measuring muscle status. In this study, we aimed to assess the correlation of the muscle quantity and quality between any vertebra level and L3 level in patients with various tumor localizations.METHODS: Two hundred-twenty Positron Emission Tomography (PET)-CT images of patients with four different tumor localizations were included: 1. head and neck ( n = 34), 2. esophagus ( n = 45), 3. lung ( n = 54), and 4. melanoma ( n = 87). From the whole body scan, 24 slices were used, i.e., one for each vertebra level. Two examiners contoured the muscles independently. After contouring, muscle quantity was estimated by calculating skeletal muscle area (SMA) and skeletal muscle index (SMI). Muscle quality was assessed by calculating muscle radiation attenuation (MRA). Pearson correlation coefficient was used to determine whether the other vertebra levels correlate with L3 level. RESULTS: For SMA, strong correlations were found between C1-C3 and L3, and C7-L5 and L3 ( r = 0.72-0.95). For SMI, strong correlations were found between the levels C1-C2, C7-T5, T7-L5, and L3 ( r = 0.70-0.93), respectively. For MRA, strong correlations were found between T1-L5 and L3 ( r = 0.71-0.95). DISCUSSION: For muscle quantity, the correlations between the cervical, thoracic, and lumbar levels are good, except for the cervical levels in patients with esophageal cancer. For muscle quality, the correlations between the other levels and L3 are good, except for the cervical levels in patients with melanoma. If visualization of L3 on the CT scan is absent, the other thoracic and lumbar vertebra levels could serve as a proxy to measure muscle quantity and quality in patients with head and neck, esophageal, lung cancer, and melanoma, whereas the cervical levels may be less reliable as a proxy in some patient groups.
DOCUMENT
We show how to estimate a Cronbach's alpha reliability coefficient in Stata after running a principal component or factor analysis. Alpha evaluates to what extent items measure the same underlying content when the items are combined into a scale or used for latent variable. Stata allows for testing the reliability coefficient (alpha) of a scale only when all items receive homogenous weights. We present a user-written program that computes reliability coefficients when implementation of principal component or factor analysis shows heterogeneous item loadings. We use data on management practices from Bloom and Van Reenen (2010) to explain how to implement and interpret the adjusted internal consistency measure using afa.
DOCUMENT
Climate change is one of the most critical global challenges nowadays. Increasing atmospheric CO2 concentration brought by anthropogenic emissions has been recognized as the primary driver of global warming. Therefore, currently, there is a strong demand within the chemical and chemical technology industry for systems that can covert, capture and reuse/recover CO2. Few examples can be seen in the literature: Hamelers et al (2013) presented systems that can use CO2 aqueous solutions to produce energy using electrochemical cells with porous electrodes; Legrand et al (2018) has proven that CDI can be used to capture CO2 without solvents; Shu et al (2020) have used electrochemical systems to desorb (recover) CO2 from an alkaline absorbent with low energy demand. Even though many efforts have been done, there is still demand for efficient and market-ready systems, especially related to solvent-free CO2 capturing systems. This project intends to assess a relatively efficient technology, with low-energy costs which can change the CO2 capturing market. This technology is called whorlpipe. The whorlpipe, developed by Viktor Schauberger, has shown already promising results in reducing the energy and CO2 emissions for water pumping. Recently, studies conducted by Wetsus and NHL Stenden (under submission), in combination with different companies (also members in this proposal) have shown that vortices like systems, like the Schauberger funnel, and thus “whorlpipe”, can be fluid dynamically represented using Taylor-Couette flows. This means that such systems have a strong tendency to form vortices like fluid-patterns close to their air-water interface. Such flow system drastically increase advection. Combined with their higher area to volume ratio, which increases diffusion, these systems can greatly enhance gas capturing (in liquids), and are, thus, a unique opportunity for CO2 uptake from the air, i.e. competing with systems like conventional scrubbers or bubble-based aeration.